Conference Presentations

2023 Fall P2SAC Conference Presentations

Tuesday, December 5: Tutorials

• Agenda 
• Overview of Layer of Protection Analysis, Kenexis 
• Best Practices for Management of Change ... , PSRG
• Assessing Corrosion Risks ... Merck
• New Computational Tools for Predicting Reactivity - Prof Savoie
• Batteries: Fundamentals, Recent Advances & Inherent Safety Aspects - Prof Pol
• Design of Electrochemical Flow Reactors - Prof Tackett

• Using Virtual Controllers in the Process Industry - Honeywell
• Process Safety Deliverables in Projects - ExxonMobil 
• Machine Learning-aided Safety Hazards Detection & Identification - Prof Li
• Nanomaterials for Low-Power Low-Cost Gas Sensors - Prof Boudouris
• Combustible Dust Flame Propagation Through Pipelines - Didion Milling Incident - CSB
• Identifying Thermal & Reactive Hazards in Manufacturing - AcuTech
• Building Our Network: Sharing for Safety - Lilly
• Executing an Incident Investigation Properly - CCPS

2023 Spring P2SAC Conference Presentations

Monday, May 8: Tutorials

• Osman P2SAC Overview spr2023.pdf
• Opportunities to Enhance Safe Chemical Manufacturing with Electrochemical Processes
• Improving Lab Safety in Academia: Free and Inexpensive Methods for Identifying High-Risk Chemistry
• Review and Update on Design Institute for Emergency Relief Systems (DIERS) 
• Strategies to Manage Chemical Incompatibility, Theis, AcuTech
• Dust Hazard Assessments, Dastidar, Fauske
• Risk Analysis Screening Tool - RAST
• Optimization Under Uncertainity, Can Li
• Fire ExpIosion Presentation - SABIC

Tuesday, May 9: Safety

• Kickoff and P2SAC Overview, Mentzer
• Update on the CSB, Hartz
• Emission Monitoring and Reduction, Gotten, Honeywell
• CCPS Handbook for Process Safety in Laboratories & Pilot Plants, Vaughn, CCPS
• Application of Inherently Safe Principles to Projects, Huff, ExxonMobil
• Purdue CERIAC-Center for cyber security... Rasmus, Purdue
• Recent NFPA Updates, Dastidar, Fauske

Wednesday, May 10: Pharma & Modeling / Simulation

• Physics Informed Response Model for Calculation of Flammable Cloud Volume ..., Vianna, Campinas
• Neural Network and CFD Simulation applied for Determination of Leak Location, Tsukada, Campinas
• Quantitative Gas Evolution Analysis via Combination of Online Thermal Massflow ..., Dixon, GSK
• Current Practices to Address Dust Explosivity Hazard Among Pharma Companies, Allian, Lilly
• Process Safety Knowledge Management, Kunt, PSRG
• Development of a PPE Selection Tool, Sathanapally, Gilead
• Unexpected Corrosion of Hastelloy by Selectfluor

2022 Fall P2SAC Conference Presentations

Wednesday, Dec 14: Tutorials

• Li-ion Battery Safety & Performance
• Use Fault Tree Analysis When LOPA Fails
• Reactive Chemicals Program & Calorimetry at Dow
• Quantum chemistry-based calculation tools, TCIT & YARP
• Leak Detection - Air Products

Thursday, Dec 15: Safety Conference

• P2SAC Overview
• Safety Management Systems & Prevention of NATECH Events
• Materials & Devices for Low-Cost Gas Sensors
• Measuring Process Safety Culture: Beyond the Bradley Curve
• Chemical Engineering Collaboration to Support Early Phase Acceleration
• Why do we use ADT24 - BMS
• Practical Use of AKTS Modeling
• Systems Engineering and Process Safety - Li
• Enhancing Safe Chemical Manufacturing with Electrochemical Processes - Tackett
• Automation in Process Safety Information Delivery - Lilly
• Enabling Reactive and Hazardous Processes with Continuous Flow Technologies

2022 Spring P2SAC Conference Presentations

Monday, May 9: Tutorials

• Prevention Through Design
• Chemical Security: Protecting Chemicals from People
• Demonstration of Reactive Hazard Evaluation & Analysis compilation Tool - RHEACT

Tuesday, May 10: Mini-conference on safety in the pharmaceutical industry

• P2SAC Overview
• Using O.R.E.O.S. Tool for Explosive Hazard Identification
• Calorimetric Techniques to Support your Reactive Hazards Analysis
• Ab initio calculation of Physical Properties
• Heats of Decomposition of a Series of Pharmaceutical Reagents Using an ARSST Calorimeter
• Potential Safety Hazards Associated with Pd-Catalyzed Cross-Coupling Reactions

Wednesday, May 11: Mini-conference on general safety

• Overview of P2SAC
• Port of Beirut Lebanon Explosion - Analysis and Impacts
• High-surface area oxidation: can it also happen in my plant?
• Low Power, Low Cost Gas Sensors
• Bowtie Diagrams
• Development of Process Safety Professionals
• Creating Best-In-Class Leaders with Incremental Online Learning
• Li-on Batteries Thermally Safe and Early Sensing
• Process Safety Risks in Renewable Energy

Thursday, May 12: Mini-conference on flow assurance

• Leak Detection on Liquid Pipelines
• Continuum-scale simulation tools for transport phenomena in dense suspensions
• Flow Assurance Overview and Challenges in Oil and Gas Production

2021 Fall P2SAC Conference Presentations

Monday, December 6

Welcome & Overview: Osman Basaran (Purdue University)

Practical Use of ARC Analysis for Thermal Stability Evaluation in Corteva: Min Sheng (Corteva)

Overview of FGS Performance-based Design and Coverage Analysis: Jim McGlone (Kenexis)

Reactive System ERS Design Basics & ERS Case Studies: Elizabeth Raines (Fauske)

Tuesday, December 7

Connected process plants to improve safetyin the digital world: Prasad Goteti (Honeywell)

Using elements of safety culture as a predictor of process safety outcomes: Laurence Pearlman (Marsh)

P2SAC Project Overview Presentation: Ray Mentzer (Purdue University)

Tool to calculate LFL and UFL of flammable mixtures with inerts: Joe Jakubowicz (Purdue University)

Experimental vs. predicted heats of reaction for some common reaction types in pharma industry: Katherine Young (Purdue University)

Low-Power, Low-cost Gas Sensors with High Specificity for Hydrogen Gas: Bryan Boudouris (Purdue University)

Industrial Perspectives on Energetic Materials: Xuemin Chen (Dow)

Thermal Instability and Associated Potential Safety Hazards of [Rh(ethylene)2Cl]2 Catalyst: Daniel Valco (Corteva)

Use of Quantum Mechanical calculations in Thermal Hazard Assessment: Fareed Sayeed (Lilly)

BICYCLO 1.1.1]PENTANE –A RISING PROCESS SAFETY CHALLENGE: Connor Barrett and Jeff Sperry (Vertex)

Sustainability Metrics for Small Molecule Development: Abe Schuitman (Corteva)

Quantum Chemical Prediction of Molecular Thermodynamics to Assess Reaction Safety and Scale-up: Qiyuan Zhao (Purdue University)

Impedimetric Chemo-sensing of Volatile Organic Compounds Released from Li-ion Batteries: Vilas G. Pol (Purdue University)

Wednesday, December 8

Workplace Excellence Management System (CountryMark)

3M's EHS Management Systems - An element-based approach

2021 Spring P2SAC Conference Presentations

Thursday, May 13

Challenges in Flammability Testing and Application: Robert Bellair (The Dow Chemical Company)

Practical Applications, Extensions and Limits of Reactive Chemical Testing Tools: Katie Mulligan (The Dow Chemical Company)

Friday, May 14

AI for Process Optimization Reliability and Safety: Kathy Shell (aeSolutions)

Common Cause Failure: What Are They and How to Mitigate Them?: Tekin Kunt (Process Safety and Reliabilty Group)

Commonly Missed Overpressure Scenarios: Wahid Wakil (Smith & Burgess)

Analysis of Cybersecurity Risks for Proposed Remote CISTAR Facilities: Abhijit Talpade (CISTAR)

Analysis of Cybersecurity Risks for Proposed Remote CISTAR Facilities: David Moore (AcuTech)

Sustaining Effective Process Safety Programs: Jim Klein (ABS Consulting)

Organizational Health - A New Methodology & Survey for Measuring: Elizabeth Rosene (Purdue University)

Purdue Process Safety and Assurance Center (P2SAC) Welcome and Overview: Osman Basaran (Purdue University)

Purdue Process Safety and Assurance Center (P2SAC) Overview: Ray Mentzer (Purdue University)

PURDUE P2SAC-Safety shower and eyewash system: Xinyu Zhen (Purdue University)

Oops! We Did It Again: Reducing Human Error-Induced Truck Unloading Events: Sarah Eck (DEKRA Process Safety)

Monday, May 17

Gounder Research Laboratory: Chemistry and Catalysis of Nanoscale Materials: Rajamani Gounder (Purdue University)

Predicting the fire and explosion properties of early phase active pharmaceutical ingredients: Antony Janes (GSK)

Promoting a safe laboratory environment using the Reactive Hazard Evaluation & Analysis Compilation Tool (RHEACT): Pushkar Ghanekar (Purdue University)

High-Throughput Predictions of Molecular Thermodynamics and Reactivity: Brett Savoie (Purdue University)

Purdue Process Safety & Assurance Center (P2SAC) Overview - Pharma: Ray Mentzer (Purdue University)

Comparison of Computational Models and Experimental Data for Common Pharma Reactions: Caitlin Justice (Purdue University)

Heat Loss in Accelerating Rate Calorimetry (ARC) Analysis and Thermal Lag for High Self-Heat Rates: Min Sheng (Corteva AgriScience)

Thermal Stability of Temozolomide (TMZ): Jeffrey Sperry (Vertex)

2020 Fall P2SAC Virtual Conference Presentations

December 1

Safety life cycle per IEC/ISA 61511: Prasad Goteti (Honeywell)

December 7

Welcome, overview, and history and mission/goals of P2SAC: Osman Basaran (Gedge Professor ChE and Academic Director P2SAC, Purdue)

Welcome and overview of P-MS (PMP) and UG research projects: Ray Mentzer (Professor of Practice ChE and Executive Director P2SAC, Purdue)

Assessing combustible and HF gas detection requirements for lithium ion battery containing facilities: Edward Marszal (Kenexis)

Low power, low cost portable gas sensors with highly specific chemical responses: Bryan Boudouris (Professor of ChE, Purdue)

Learning from incidents - are we really learning and how to rethink investigations: Laurence Pearlman (Marsh)

Leadership in process safety, now more than ever: Trish Kerin (IChemE)

Designing safer batteries via materials architectures and multimode calorimetry: Vilas Pol (Professor ChE, Purdue)

Developing a non-contact dust layer thickness measurement system:  Kingsly Ambrose (Associate Professor ABE, Purdue) and Carl Wassgren (Professor ME, Purdue)

Sensing Dust Concentration through Imaging: Kingsly Ambrose (Associate Professor ABE, Purdue)

Understanding and managing the risk during the transient operating mode: Start-ups and Shut-downs: Bruce Vaughen (CCPS)

Prevention through design and heterogeneous catalysis: Raj Gounder (Larry and Virginia Faith Associate Professor ChE, Purdue)

Safe and efficient printed perovskite solar cells and optoelectronics: Letian Dou (Charles Davidson Assistant Professor ChE, Purdue)

Process safety scale-up aspects of a nitric acid-catalyzed hydrolysis of epichlorohydrin reaction: Donald Knoechel (Fauske)

December 10

Plans for event & overview of recent P2SAC pharma related research:  Ray Mentzer (Professor of Practice ChE and Executive Director P2SAC, Purdue)

Safe scale-up of an exothermic Grignard reaction based on thermal hazard understanding and engineering control: Ayman Allian (AMGEN)

Playing with fire? A safe and effective quench of Raney cobalt using aqueous sodium nitrate: Frank Dixon (GSK)

Assessing explosive properties in the pharmaceutical industry: Jeff Sperry (Vertex)

High-throughput predictions of molecular thermodynamics and reactivity:  Brett Savoie (Charles Davidson Assistant Professor ChE, Purdue)

Safe operating space for handling hydrogen evolved during STAB hydrolysis: Bhoja Kandela (Lilly)

Utilizing heat flow calorimetry for understanding thermal risks of chemical processes during scale-up and safety studies: Simon Rea (Mettler-Toledo AutoChem)

Explosion hazards associated with using DMSO and DMF in chemical reactions: Qiang Yang (Corteva)

Clearing the Air: Rethinking dust safety in pharmaceutical manufacturing: Rexonni Lagare (PhD candidate ChE, Purdue)

Closing comments: Ray Mentzer (Professor of Practice ChE, Purdue)

2019 Fall P2SAC Conference Presentations

December 4, 2019

Industry-led Tutorials on Process Safety Agenda

Implementing Inherent Safety - David Moore, AcuTech

Unified Hazard Assessment - Ed Marszal, Kenexis

A Tutorial for the Risk Analysis Screening Tool (RAST) - Bruce Vaughen, CCPS

• P2SAC 4 Dec RAST - Handout Glossary
• P2SAC 4 Dec RAST - Handouts Tutorial.1
• P2SAC 4 Dec RAST - Handouts Tutorial.2
• P2SAC 4 Dec RAST - Handouts Tutorial.3
• P2SAC 4 Dec RAST - Handouts Tutorial.4
• P2SAC 4 Dec RAST - Handouts Tutorial.5
• P2SAC 4 Dec RAST - Handouts Tutorial.6
• P2SAC 4 Dec RAST - Handouts Tutorial.7
• P2SAC 4 Dec RAST - Handouts BP Case Study.1
• P2SAC 4 Dec RAST - Handouts BP Case Study.2
• P2SAC 4 Dec RAST - Handouts BP Case Study.3
• P2SAC 4 Dec RAST - Handouts BP Case Study.4
• P2SAC 4 Dec RAST - Handouts BP Case Study.5
• P2SAC 4 Dec RAST - Handouts BP Case Study.6

December 5, 2019

Purdue Process Safety & Assurance Center - P2SAC Highlights - Ray Mentzer, Executive Director of P2SAC

30 Years Later: Remembering the Explosion at Pasadena - Bruce Vaughen, CCPs, and Kenneth Bloch

The Convergence of Process Safety and Security Strategies for Critical Infrastructure Protection of Emerging Threats - David Moore, AcuTech

CyberPHA: A proven method to assess industrial control system cybersecurity risk - Jacob Morella, aeSolutions

How is your process safety culture? Better practices and approaches to self-assessment - Laurence Pearlman, Marsh

Industrial Examples of Misuse of DSC Crucibles for Thermal Stability Hazard Evaluation - Min Sheng, Corteva

Lithium Ion Battery Thermal Runaway - Ed Marszal, Kenexis

Process Safety at Vertex Pharmaceuticals (<5L Scale) - Jeffrey B. Sperry, Vertex

Process Safety Risk Index Calculation Based on Historian Data - Prasad Goteti, Safety Engineering Consultant, Honeywell

Reducing the human error impact on Safety Instrumented System (SIS) - Charles Fialkowski, Siemens

Right sizing combustible particulate management while meeting NFPA 652 requirements - Denise Albrecht, 3M

2019 Spring P2SAC Conference Presentations

May 7, 2019

P2SAC 2019 Spring Conference Agenda

Welcome and Opening Remarks - Ray Mentzer, Visiting Professor and Executive Director of P2SAC

Academic & Industrial Lab Safety Project - Sopuru Ezenwa, Purdue, PhD student

Advancing Industry 4.0 in Pharmaceutical Manufacturing: Integrating the Process Safety Perspective - Rex Reklaitis, Professor of ChE

Managing Heat Accumulation at Scale Using a Kinetic Model - Li-Jen Ping, Johnson Matthey

Pharma Process Safety-Instrumentation Assets: Health & Performance Monitoring - Ravi Shankar, Endress+Hauser

Overview for Pharmaceutical Related Research - Ray Mentzer, Visiting Professor and Executive Director of P2SAC

May 8, 2019

The Challenge of Combustible Dust - Kenneth Tague, ADM

Cybersecurity and hydrocarbon processing facilities (a CISTAR/P2SAC joint project) - Eric Dietz and Joe Pekny, Professors, Purdue

Kenexis Sponsored P2SAC Research - Ed Marszal et al.

Safety Evaluation of the Copper-Mediated Cross-Coupling of 2-Bromopyridines with Ethyl Bromodiflouroacetate in DMSO - Qiang Yang, Dow Agro/Corteva

May 9, 2019

Efficacy of crop protection offerings based upon drop sizes and the break-up of sprayed emulsions from flat-fan nozzles - Steve Cryer/Madan Somasi, Corteva Agriscience

Research on two-phase flows using two-fluid model - Subash Sharma, Purdue NE

Surfactants and DST effects in EOR/flow assurance - Jaeyub Chung, Purdue

2018 Fall P2SAC Conference Presentations

P2SAC Fall 2018 Conference Agenda

Welcome to the P2SAC Fall 2018 Conference - Dr. Osman Basaran

P2SAC Highlights - Dr. Ray Mentzer

Characterization of Reactive Chemical Hazards via Calorimetry - Sai Sathanapally

Driving PSM Performance Beyond KPI Metrics - Dr. Stewart W. Behie

Prevention Through Catalyst Design for Application in the Petrochemical Industry - Dr. Rajamani Gounder

Process Safety and the Front Line - Pearlman & Onofre, Marsh Risk Consulting

PMP Project Data Structure Standardization for PHA - Ed Marszal

The Role of Inertia in Coalescence of Drops in Liquid-Liquid Emulsions - Dr. Osman A. Basaran

Trust, But Verify: The case for placing the entire safety lifecycle in one accessible place - Honeywell

Overview of Continuous Pharmaceutical Manufacturing - Dr. Zoltan Nagy

Parametric Sensitivity and Thermal Runaway Behavior in Catalytic Fixed Bed Reactors - Dr. Arvind Varma and Yang Ziao

P2SAC Fall 2018 Faculty Pitches

Faculty Pitch: Electrocoalescence - Dr. Osman Basaran

Faculty Pitch: High-throughput quantum chemical calculation of Benson group values for reliable thermodynamic characterization - Dr. Brett Savoie

Faculty Pitch: Modeling and Uncertainty Analysis of Dust Explosions - Dr. Zoltan Nagy

Faculty Pitch: Molecular property prediction based on scarce data using a novel machine learning framework - Dr. Brett Savoie

Faculty Pitch: Safer Materials & Processing Design for Next Generation Printed Electronics - Dr. Leitan Dou

Faculty Pitch: Sensing Dust Concentration by Imaging - Dr. Kingsly Ambrose

2018 Spring P2SAC Conference Presentations

P2SAC Highlights - Dr. Ray Mentzer

Driving Chemical Change: the Chemical Safety Board's First 20 years - Dr Kristen Kulinowski (CSB)

Flow Assurance: Drop Coalescence in the Presence of Surfactants - Vishrut Garg (Basaran)

Early Phase Thermal Hazards Assessments at Eli Lilly - Dr. Stan Kolis (Lilly)

Inherently Safer Process Design - Dr. Jeff Sperry (Pfizer)

Minimum Ignition Energy (MIE) of Dust Clouds - Ashok Dastidar (Fauske & Associates)

Open Source Data Schema for Process Safety - Ed Marszal (Kenexis)

Proof Testing Safety Instrumented Systems - Prasad Goteti (Honeywell)

Real Time Release in Continuous Solid Dose Manufacturing - Dr. Qinglin Su (Nagy)

Society of Chemical Manufacturers & Affiliates - Joe Dettinger (SOCMA)

2017 Fall P2SAC Conference Presentations

Flow Assurance: Drop and Bubble Coalescence and Thin Film Rupture - Prof Osman Basaran

Introduction and Status Update – Prof Osman Basaran

P2SAC Highlights - Dr. Ray Mentzer

Prevention Through Catalyst Design for Applications in the Petrochemical Industry - Prof Raj Gounder

Prevention Through Design - Jonathan Bach, NIOSH

SIL Rated Communication Protocols - Prasad Goteti, Honeywell

Waste/Side Stream Testing Guidelines at Pfizer - Dr. Jeffrey Sperry, Pfizer

2017 Spring P2SAC Conference Presentations

P2SAC Research Program & Accomplishments - Dr. Ray Mentzer

Dust Explosion Test Methodologies - Dr. Ashok Dastidar, Fauske

Storage Tank Dike Design - Dr. George Harriott, Air Products

Key Performance Indicators for Installed SIS - Prasad Goteti, Honeywell

Robust Model-Based Control for Safe Pharmaceutical Manufacturing - Prof. Zolton Nagy

Chemistry & Catalysis of Nanoscale Materials - Prof. Raj Gounder

Latest Developments in Inherently Safer Technology - Mr. Brad Fuller, AcuTech

2016 Fall P2SAC Conference Presentations

Safer Catalytic Oxidations - Raj Gounder (PDF)

Advances in Chemical Reactivity Evaluation at Dow (PPTX)

Overview of Core UG Chemical Process Safety Course (PDF)

Fault Tolerant Control for Safe Plant Operation (PDF)