Advancements in biotransport imaging and cell tracking dynamics
| Interdisciplinary Areas: | Data and Engineering Applications, Autonomous and Connected Systems, Innovation and Making |
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Project Description
The local microenvironment plays a significant role in tissue development, homeostasis, and disease progression. Specifically, the microenvironment controls dynamic processes such as cell and mass transport. Changes in the microenvironment play a particularly important role in disease progression. However, evaluating how changes in the microenvironment drive functional changes in tissue is complicated by the inter-relationships between the protein composition, protein structure, mechanical properties, local physiology, and cellular composition. There is a need to develop tools capable of interrogating the interplay of these components to understand how the underlying physics drives the biological event within tissues.
We have developed tools for quantitative image analysis to evaluate the biomechanics (stress-strain relationship and deformation), convective flow, diffusion and biotransport phenomena, and cellular dynamics. Current work investigates the role of the extracellular matrix composition on cell and mass transport. The proposed post-doctoral program will expand these approaches using advanced microscopy, interferometry, and photoacoustic imaging to increase the overall arsenal of tools that can be used to evaluate tissues and biological phenomena in multidimensional space.
The program will tackle basic and translational questions, such as tissue injury and wound healing, drug delivery and transport across tissue interfaces (e.g., blood-brain barrier), and cancer metastatic processes, including aspects of personalized medicine.
This postdoctoral program will integrate aspects of intellectual property development, technology transfer, commercialization and entrepreneurship, industry partnerships, external funding proposal development, and clinical study design and translation.
Start Date
June 1, 2025
Postdoc Qualifications
*Highly motivated and independent researcher
*Excellent written and oral communication skills
*Strong publication record
*Eager to join interdisciplinary team that touches on topics in chemical engineering, materials science, and biomedical engineering
Co-advisors
Luis Solorio, lsolorio@purdue.edu, Weldon School of Biomedical Engineering, https://soloriolab.wixsite.com/tmet?_ga=2.18586361.1513187059.1625151713-956620504.1620310884
Pavlos Vlachos, pvlachos@purdue.edu, Mechanical Engineering
https://vlachosresearch.org
Bibliography
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Fibronectin-expressing mesenchymal tumor cells promote breast cancer metastasis BH Jun, T Guo, S Libring, MK Chanda, JS Paez, A Shinde, MK Wendt, P Vlachos, L Solorio Cancers 12 (9), 2553 High‐Throughput Magnetic Actuation Platform for Evaluating the Effect of Mechanical Force on 3D Tumor Microenvironment Á Enríquez, S Libring, TC Field, J Jimenez, T Lee, H Park, D Satoski, MK Wendt, S Calve, A Buganza Tepole, L Solorio, H Lee Advanced Functional Materials 31 (1), 2005021 Rose Bengal Labeled Bovine Serum Albumin for Protein Transport Imaging in Subcutaneous Tissues Using Computed Tomography and Fluorescence Microscopy MH Hakim, MC Brindise, A Ahmadzadegan, KP Buno, ACF Dos Santos, ... Bioconjugate Chemistry Mechanistic Computational Modeling of Implantable, Bioresorbable Drug Release Systems PA Giolando, K Hopkins, BF Davis, N Vike, A Ahmadzadegan, AM Ardekani, PP Vlachos, JV Rispoli, L Solorio, TL Kinzer‐Ursem Advanced Materials 35 (51), 2301698 |