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Medical Imaging Diagnostic Technologies


Credit Hours:


Learning Objective:

The goal is to have the students master the universal principles and ideas rather than a smattering of individual techniques.


This gateway course will provide an introduction to the physics, technologies, and biological considerations associated with modern imaging and diagnostic tools. Specific modalities to be examined will include x-ray, nuclear imaging, ultrasound, MRI, and microscopy techniques such as phase contrast, DIC, confocal microscopy, two-photon microscopy as well as concept of adaptive optics, light-sheet microscopy, 4Pi microscopy, and modern super-resolution microscopy techniques (PALM/STORM, STED and IM). The course also covers principles of optics, contrast generation (including genetically encoded probes and physiological indicators), image formation, detection, and analysis.

Topics Covered:

Overview/Math Foundations/Energy-Matter Interactions.
Physiological Limitations of Energy Exposure.
Projection Tomographic Concepts (X-ray/CT).
Emission Tomographic Concepts (PET/SPECT).
Reflection Tomography (US/Optical).
Diffusion Tomographic Concepts (Optical).
Resonance Tomographic Concepts (MRS/MRI).
Mass Spectrometry.
In addition, through guest lectures (GL), we will hear the recent research progresses and corresponding biomedical applications in areas such as OCT, ultrasound, MRI, fluorescence microscopy, electron microscopy, concurrent MRI and optical functional imaging, and Coherent anti-Stokes Raman spectroscopy.
This course also includes a crash sub-course on MATLAB programming including both introductory content and contents of MATLAB-C API and MATLAB-C-CUDA (GPU computing).


None specified; contact instructor or department to discuss if you are unsure whether you have the necessary background and skills.

Applied / Theory:

Web Content:

Syllabus, notes and assignments.


Several homework assignments will be made during the course of the semester.


Several individual projects (research reports, programming projects) will be assigned during the course of the semester. Topics will relate to imaging physics, data acquisition, image formation and applications.


One midterm and a final exam.


Official textbook information is now listed in the Schedule of Classes. NOTE: Textbook information is subject to be changed at any time at the discretion of the faculty member. Required: Fundamentals of Light Microscopy and Electronic Imaging, Douglas B. Murphy, Wiley-Blackwell, 2nd, ISBN: 9780471692140 Introduction to Biomedical Imaging, Andrew G. Webb, Wiley-IEEE Press, 1st, ISBN: 9780471237662 The Essential Physics of Medical Imaging, Third Edition, Jerrold T. Bushberg, LWW, ISBN: 9780781780575

Computer Requirements:

ProEd Minimum Computer Requirements

ProEd Minimum Requirements: