Dr. Joseph Wallace
Areas of Research
Musculoskeletal biomechanics and mechanobiology
- Targeting collagen as an interventional approach to improve bone material properties
- Profiling of raloxifene and raloxifene analogs: effects on cell behavior and bone material properties
The Bone Biology and Mechanics Lab (BBML) focuses on bone mechanics (ability to effectively bear loads) and mechanobiology (how cells respond to mechanical stimuli to maintain and/or increase bone mass). We investigate bone from mechanical engineering and materials science perspectives by tying morphology and composition to mechanical function and fracture resistance at discrete length scales throughout bone's hierarchy
A common thread that passes through all of our research is an intense focus on collagen and the role it plays in bone health. Our goal is to use combinatorial treatments for diseases that have musculoskeletal complications which lead to bone fragility and fracture. Our current focus is on mechanical and pharmaceutical manipulations of bone quality and quantity.
Being in Indianapolis, on campus with the Indiana University Medical Center, we have unique collaborative opportunities with clinicians and researchers in the Departments of Anatomy and Cell Biology, Nephrology, Orthopaedic Surgery, and Biology.
Looking for one highly motivated PhD student with experience in bone-related research or general mechanical and compositional characterization of materials.
Please feel free to contact Dr. Wallace directly.