Engineered Biomaterials and Biomechanics


Meng Deng, Assistant Professor of Biomedical Engineering, co-authored Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity. June 5, 2017.
Russ Main has published Osteocytes and the bone lacunar-canalicular system: Insights into bone biology and skeletal function using bone tissue microstructure, International Journal of Paleopathology, Available online 15 May 2017.
Eric Nauman and Lia Stanciu are co-authors on Bioresorbable Fe–Mn and Fe–Mn–HA Materials for Orthopedic Implantation: Enhancing Degradation through Porosity Control, Adv. Healthcare Mater. April, 27, 2017.
Taeyoon Kim, assistant professor of bioengineering and professor of pharmaceuticals, co-authored the publication Buckling-induced F-actin fragmentation modulates the contraction of active cytoskeletal networks.

Biomaterials research focuses on how natural and synthetic materials interact with biological systems. These range from the inert materials used to replace entire joints to biomimetic scaffolds that restore functionality by promoting the body to regenerate the lost tissue. Research at the Weldon School of Biomedical Engineering covers all facets of this exciting area. From advanced studies characterizing the instructive role of extracellular matrix components, to developing novel polymeric biomaterials, researchers and students are finding new ways to replace, repair, or regenerate tissues lost or damaged from injury and disease.

Critical parameters that inspire biomaterial and implant design are the mechanical environment into which it will be placed and how cells sense and respond to mechanophysical cues, otherwise known as mechanobiology. By studying the strengths and weaknesses of individual tissue components, researchers are improving not only our understanding of the body, but also the devices needed to repair the body. Biomechanics research at the Weldon School spans experimental and computational design at multiple length scales, including studies into how external forces impact the body as a whole all the way down to quantifying how subcellular deformations influence gene expression.

The interdisciplinary team at the Weldon School of Biomedical Engineering is building on a solid foundation of accomplishment. From studies that can detect microfractures in bones before they can evolve into a problem, to advanced implants that monitor themselves and the environment around them, researchers are developing the knowledge and clinical treatments that will change the way we view and repair the body.

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