Dr. Deva Chan
Areas of Research
Orthopaedic Biomechanics and Mechanobiology
The Chan Laboratory believes that understanding the early tissue response to injury is critical to diagnosis, assessment, and intervention in life-altering orthopedic diseases, including post-traumatic osteoarthritis. True to our biomedical engineering roots, we adopt a multi-disciplinary approach - using biomechanics, biomedical imaging, and matrix biology - to quantify this complexity in health, injury, and repair processes.
We have openings for the following federally funded projects:
- Mechanobiology of extracellular matrix synthesis: Progenitor cells of the synovial joint produce hyaluronan and other ECM molecules to provide compressive strength, support lubrication, and otherwise respond to injury. This project aims to elucidate how biomechanical stimuli regulates the synthesis and breakdown of hyaluronan and, conversely, how these extracellular matrix changes feed back to alter mechanical function and biological processes in the synovial joint.
- Interactions of the gut microbiome with the healthy and post-traumatic synovial joint: Despite the growing appreciation for the myriad effects of commensal bacteria on health and disease, the role of gut microbes on the synovial joint remains poorly understood. This project aims to understand how alterations in the gut microbiome may alter, the turnover of hyaluronan and other glycosaminoglycan, complex sugars that play critical mechanical and biological roles in the synovial joint.
Co-advised projects are also possible in ongoing collaborative directions!
- Bioelectrical interventions to alleviate musculoskeletal pain (with Dr. Matthew Ward)
- Computational biology for mouse-to-human translation in orthopedic disease (with Dr. Douglas Brubaker)
Creative and versatile self-starters from diverse technical and personal backgrounds to contirubte to our team as PhD students in Fall 2022.
Please feel free to contact Dr. Chan directly.