Joseph Wallace

Joseph Wallace

Acting Dean of the School of Engineering and Technology and Professor of Biomedical Engineering
Professor of Biomedical Engineering


Phone: 317-274-2448

Department of Biomedical Engineering
723 West Michigan Street, SL 220
Indianapolis, IN 46202-5132

Research web site:

Personal web site:


  • BS, Aerospace Engineering, Georgia Institute of Technology, 2002
  • MS, Biomedical Engineering, The University of Michigan, 2004
  • PhD, Biomedical Engineering, The University of Michigan, 2007



  • B.S. Aerospace Engineering, Georgia Institute of Technology, 2002
  • M.S. Biomedical Engineering, The University of Michigan, 2004
  • Ph.D. Biomedical Engineering, The University of Michigan, 2007

Professional Experience

  • Postdoctoral Fellow, The University of Michigan, Department of Chemistry and Michigan Nanotechnology Institute for Medicine and Biological Sciences, 10/2007 - 9/2010
  • Graduate Research Assistant, The University of Michigan, Biomimetics and Biomechanics of Hard Tissues Laboratory, Department of Biomedical Engineering, 5/2002 - 10/2007

Awards and Honors

  • The lab was awarded a 5 year, nearly $2M grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)! The grant is titled "Targeting collagen as an interventional approach to improve bone material properties." This work is focused on combination treatments which impact bone quantity and quality for a number of relevant diseases which have musculoskeletal complications., 7/2018
  • IUPUI Trustees' Teaching Award, 3/2018

Selected Publications

  • Hammond MA, Wallace JM, Allen MR, Siegmund T, "Incorporating Anisotropy and Heterogeneity in Finite Element Models of Trabecular Bone Altered Predicted Stress," Biomechanics and Modeling in Mechanobiology, 2018; 17(2): 605-614., 10/2018
  • Hongji Z, Harbin S, Brookes SE, Wallace JM, Halum S, "Use of autologous adipose-derived mesenchymal stem cells for creation of laryngeal cartilage," The Laryngoscope, 2018; 128: E123-E129., 10/2018
  • Allen MR, McNerny EMB, Aref MW, Organ JM, Newman CL, McGowan B, Jaing T, Burr DB, Brown DM, Hammond MA, Territo PR, Lin C, Persohn S, Jiang L, Riley AA, McCarthy BP, Hutchins GD, Wallace JM, "Effects of combination treatment with Alendronate and Raloxifene on skeletal properties in a beagle dog model," PloS One, 2017; 12(8): e0181750., 10/2018
  • Stringer M, Abeysekera I, Thomas J, LaCombe J, Stancombe K, Stewart R, Dria K, Wallace JM, Goodlet C, Roper R, "Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes," Physiology and Behavior, 2017; 177: 230-241., 10/2018
  • Larsen R, Peveler J, Klutke J, Hickman D, Aref MW, Wallace JM, Brown D, Allen MR, "Effects of daily restraint with and without injections on skeletal properties in C57BL/6NHsd mice," Lab Animal, 2017; 46(7): 299-301., 10/2018
  • Meixner CN, Aref MW, Gupta A, McNerny EMB, Brown D, Wallace JM, Allen MR, "Raloxifene improves bone mechanical properties in mice previously treated with zoledronate," Calcified Tissue International, 2017; 101(1): 75-81., 10/2018
  • TruongVo T, Kennedy RM, Chen H, Chen A, Berndt A, Agarwal M, Zhu L, Naksharti H, Wallace JM, Na S, Yokota H, Ryu JE, "Microfluidic Channel for Characterizing Normal and Breast Cancer Cells," Journal of Micromechanics and Microengineering, 2017; 29; 035019., 10/2018
  • Pacheco-Costa R, Kadakia JR, Wallace JM, Plotkin LI, Reginato RD, "Connexin37 deficiency alters organic bone matrix, cortical bone geometry, and increases Wnt/β-catenin signaling," BONE, 2017; 97:105-113., 10/2018
  • Vesper EO, Hammond MA, Allen MR, Wallace JM, "Even With Rehydration, Preservation in Ethanol Influences the Mechanical Properties of Bone and How Bone Responds to Experimental Manipulation," BONE, 2017; 97:49-53., 10/2018
  • Sugatani T, Agapova OA, Fang Y, Berman AG, Wallace JM, Malluche H, Smith W, Sung V, Hruska KA, "Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease," Kidney International, 2017; 91(1): 11-13., 10/2018
  • Allen MR, Aref MW, Newman CL, Kadakia JR, Wallace, JW, "Raloxifene neutralizes bone brittleness induced by anti-remodeling treatment and increases fatigue life through non-cell mediated mechanisms," Actualizaciones en Osteologia, 2016; 12(3): 163-173., 10/2018
  • Takigawa H, Frondorf B, Liu S, Liu Y, Li B, Sudo A, Wallace JM, Yokota H, Hamamura K, "Salubrinal improves mechanical properties of the femur in osteogenesis imperfecta Mice," Journal of Pharmacological Sciences, 2016; 132(2):154-161., 10/2018
  • Canelon S, Wallace JM, "β-aminopropionitrile-induced reduction in enzymatic crosslinking causes in vitro changes in collagen morphology and molecular composition," PloS One, 2016; 11(11): e0166392., 10/2018
  • Hammond MA, Berman AG, Laine TJ, Wallace JM, "Treadmill Exercise Improves Fracture Toughness and Indentation Modulus Without Altering the Nanoscale Morphology of Collagen in Mice," PloS One, 2016; 11(9): e0163273., 10/2018
  • McNerny EMB, Organ JM, Wallace JM, Newman CL, Brown DM, Allen MR, "Assessing the inter- and intra-animal variability of in vivo OsteoProbe skeletal measures in untreated dogs,", Bone Reports, 2016; 5: 192-198., 10/2018
  • Hammond MA, Berman AG, Pacheco R, Davis HM, Plotkin LI, Wallace JM, "Removing or truncating connexin 43 in murine osteocytes alters cortical geometry, nanoscale morphology, and tissue mechanics in the tibia," Bone, 2016; 88: 85-91., 10/2018
  • Krege B, Aref M, McNerny E, Wallace JM, Organ JM, Allen MR, "Reference point indentation is insufficient for detecting alterations in traditional mechanical properties of bone under common experimental conditions," Bone, 2016; 87: 97-101., 10/2018
  • Blum KM, Novak T, Neu CP, Wallace JM, Bart ZR, Voytik-Harbin SL, "Acellular and Cellular High-Density, Collagen-Fibril Constructs with Suprafibrillar Organization," Biomaterials Science, 2016; 4: 711-723., 10/2018
  • Newman CL, Tian N, Hammond MA, Wallace JM, Brown DM, Chen NX, Moe SM, Allen MR, "Calcitriol Suppression of Parathyroid Hormone Fails to Improve Skeletal Properties in an Animal Model of Chronic Kidney Disease," American Journal of Nephrology, 2016; 43(1): 20-31., 10/2018
  • Berman AG, Wallace JM, Bart ZB, Allen MR, "Raloxifene reduces skeletal fractures in an animal model of osteogenesis imperfecta", Matrix Biology, 2016; 52-54: 19-28., 10/2018


Mechanical Properties of Biological Tissues, Mechanically-mediated skeletal adaptation, Atomic Force Microscopy


Role collagen plays in bone health and fracture resistance; Mechanically-mediated skeletal adaptation; Combinatorial drug and mechanical therapeutics for defects and disease in bone; Hierarchical structure/function relationships in cells, tissues and organs

Research Interests

  • Role collagen plays in bone health and fracture resistance
  • Mechanically-mediated skeletal adaptation
  • Combinatorial drug and mechanical therapeutics for defects and disease in bone
  • Hierarchical structure/function relationships in cells, tissues and organs