An article titled "Fluorescence Optical Diffusion Tomography" by Professors Charles Bouman and Kevin Webb is one of the top 15 most cited in Applied Optics for the past 10 years. It was originally published in 2003, and was also written by Adam Milstein, Seungseok Oh, Quan Zhang, David Boas, and R.P. Millane. OSA's Applied Optics is one of the most cited journals in optics and photonics and is an important source for applications-centered research that moves the potential of science and technology to the practical.

Abstract:
A nonlinear, Bayesian optimization scheme is presented for reconstructing fluorescent yield and lifetime, the absorption coefficient, and the diffusion coefficient in turbid media, such as biological tissue. The method utilizes measurements at both the excitation and the emission wavelengths to reconstruct all unknown parameters. The effectiveness of the reconstruction algorithm is demonstrated by simulation and by application to experimental data from a tissue phantom containing the fluorescent agent Indocyanine Green.