Professional Experience

• Assistant Professor, Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, 8/2010 - present
• Postdoctoral Associate, Department of Chemical & Biological Engineering, Howard Hughes Medical Institute & University of Colorado at Boulder, 9/2007 - 7/2010
• Graduate Research Assistant, Department of Bioengineering, Clemson University, 8/2004 - 8/2007

Awards & Honors

• Editorial Board Member: Gels
• Editorial Advisory Board Member: ACS Biomaterials Science & Engineering
• Abraham M. Max Distinguished Professor Award, Purdue School of Engineering & Technology, IUPUI. 2017
• Honorary Scientist and Advisor on Agricultural Science & Technology, the Rural Development Administration of the Republic of Korea, 7/2017
• US Frontiers of Engineering Symposium Invitee, National Academy of Engineering, 9/2015
• Faculty Early Career Development (CAREER) Award, National Science Foundation, 7/2015
• Purdue Summer Faculty Research Grant, Purdue Research Foundation, 7/2014
• Young Investigator Award, Frontiers in Bioengineering Workshop, Georgia Institute of Technology, 2/2013
• American Institute of Chemists Postdoctoral Award, University of Colorado, 7/2010
• Outstanding Graduate Research Assistant Award, Graduate School & Clemson University Research Foundation, 7/2007
• Outstanding Graduate Researcher Award, College of Engineering & Science, Clemson University, 7/2007

Selected Publications

• Nguyen HD, Liu HY, Hudson BN, Lin CC*. Enzymatic crosslinking of dynamic thiol-norbornene click hydrogels. ACS Biomaterials Science & Engineering 2019 (5) 1247-1256
• Arkenberg MR, Moore D, and Lin CC*. Dynamic control of hydrogel crosslinking via sortase-mediated reversible transpeptidation. Acta Biomaterialia 2019 (83) 83-95
• Liu HY, Nguyen H, Lin CC*. Dynamic PEG-peptide hydrogels via visible light and FMN-induced tyrosine dimerization.Advanced Healthcare Materials 2018 (7) 1800954
• Lin CC*, Korc M. Designer hydrogels: Shedding light on the physical chemistry of the pancreatic cancer microenvironment. Cancer Letters 2018 (436) 22-27
• Liu HY, Korc M, and Lin CC*. Biomimetic and enzyme-responsive dynamic hydrogels for studying cell-matrix interactions in pancreatic ductal adenocarcinoma. Biomaterials 2018 (160) 24-36
• Arkenberg MR and Lin CC*. Orthogonal enzymatic reactions for rapid crosslinking and dynamic tuning of PEG-peptide hydrogels. Biomaterials Science 2017 (5) 2231-2240
• Liu HY, Greene T, Lin TY, Dawes CS, Korc M, and Lin CC*. Enzyme-mediated stiffening hydrogels for probing activation of pancreatic stellate cells. Acta Biomaterialia 2017 (48) 258-269
• Shih H, Greene T, Korc M, and Lin CC*. Modular and adaptable tumor niche prepared from visible light-initiated thiol-norbornene photopolymerization. Biomacromolecules 2016 (17) 3872-3882
• Shih H and Lin CC*. Tuning stiffness of cell-laden hydrogels via host-guest interaction. Journal of Materials Chemistry B 2016 (4)4969-4974
• Ki CS, Lin TY, Korc M, and Lin CC*. Thiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance. Biomaterials 2014(35) 9668-9677
• Lin TY, Ki CS, and Lin CC*. Manipulating hepatocellular carcinoma cell fate in orthogonally cross-linked hydrogels.Biomaterials 2014(35) 6898-6906
• Munoz Z, Shih H, and Lin CC*.Gelatin hydrogels formed by orthogonal thiol-norbornene photochemistry for cell encapsulation. Biomaterials Science 2014(2) 1063-1072
• Hao Y, Shih H, Munoz Z, Kemp A, Lin CC*. Visible light cured thiol-vinyl hydrogels with tunable degradation for 3D cell culture. Acta Biomaterialia 2014(10) 104-114
• Raza A, Ki CS, and Lin CC*. The influence of matrix properties on growth and morphogenesis of pancreatic ductal epithelial cell in 3D. Biomaterials 2013(34) 5117-5127
• Shih H and Lin CC*. Visible light-mediated thiol-ene hydrogelation using eosin-Y as the only photoinitiator.Macromolecular Rapid Communications 2013(34) 269-273
• Shih H and Lin CC*. Crosslinking and degradation of step-growth hydrogels formed by thiol-ene photo-click chemistry.Biomacromolecules 2012(13) 2003-2012
• Lin CC*, Raza A, Shih H. PEG hydrogels formed by thiol-ene photo-click chemistry and their effect on the formation and recovery of insulin-secreting cell spheroids. Biomaterials 2011(32) 9685-9695

Expertise

Biomaterials, photopolymerizations, tissue engineering, bioconjugate chemistry

Interests

Our research focuses on designing multifunctional polymeric biomaterials, including hydrogels, nanoparticles, and cell surface coatings, for releasing therapeutically relevant agents and for delivering adult, stem, and progenitor cells for tissue engineering and regenerative medicine applications.