Abstract: Tyrosine phosphorylation, the regulated addition of a phosphate group to a tyrosine residue, is a cornerstone of cell signaling that guides the development and regulation of human tissues. The discovery of tyrosine phosphorylation (pTyr) sites in the human proteome has far outpaced our understanding of them, i.e. which enzymes they are regulated by and what the resulting effect is of phosphorylation. The Naegle lab develops computational and molecular tools to improve our knowledge of pTyr in a systems-level way, chipping away at the unknown in a manner that is faster than studying one modification on one protein at a time. This seminar is a “build-your own adventure”, where I hope to share our excitement for pTyr, its importance, and the ways we integrate across computer science, mathematics, engineering, and biology to tackle the challenge. Seminar attendees will get to select the specific stories from the lab they would like to hear that span from evolutionary to structural, from network inference to machine learning, from computational to experimental, and from the basic sciences to the translational impact in cancer.  

Bio: Kristen M. Naegle is an associate professor of Biomedical Engineering and the Department of Genome Sciences at the University of Virginia. Dr. Naegle was assistant professor of Biomedical Engineering and Computer Science and Engineering (courtesy appointment) at Washington University in St. Louis from 2012 to 2018. Dr. Naegle received her Ph.D. in 2010 from the Massachusetts Institute of Technology in Biological Engineering and was subsequently trained as a postdoctoral associate at the Koch Institute for Integrative Cancer Research. Prior to her Ph.D. training, Dr. Naegle earned a B.S. and a M.S. in Electrical Engineering from University of Washington. Her lab builds molecular and computational tools to understand the role of tyrosine phosphorylation within proteins and protein networks. Dr. Naegle’s work has been funded by the NCI, NIGMS, and NAIAD.

~ BME Host: Tami Kinzer-Ursem/cohost: Elsje Pienaar~

Research Quote of the Week: Research is not measured by the time it took, nor the time of day when it was done. It is only measured by the results." - Leslie A. Geddes, Founder of Biomedical ENgineerng at Purdue, est. 1974

ZOOM LINK: https://purdue-edu.zoom.us/j/92740889745?pwd=KDbLkQqhlvhpVqSAvfOptQmNklC3kw.1

*Note: Students enrolled in the seminar course are expected to attend in person.

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