BME Summer Seminar - July 17
"Emulating Physiology: A Tissue Engineering Approach for Cartilage Defect Intervention" will be presented by Tyler Novak (Dr. Corey Neu, advisor).
Abstract: Over the past few decades, the field of tissue engineering has seen few products actually reach the patient population. Recent research reveals that this may be due to a fundamental misunderstanding of the structural and cellular requirements for proper implant integration and regeneration. The recent successes of decellularized tissue in vivo as well as landmark in vitro experiments suggest that an implant that closely mimics the native tissue will lead to successful integration and regeneration. Specifically, the emulation of the mechanical, biological, and architectural properties of native tissue has individually been shown to elicit a desirable cellular response both in vivo and in vitro. With this concept in mind, we are developing unique collagen scaffolds to mimic these properties, and further testing their functional response.
Through the use of magnetic alignment of collagen, we are able to emulate the fibril architecture of articular cartilage and show tunable mechanics and desired cell-matrix interaction. Using a novel collagen extraction method, we are isolating type II collagen in its fully intact form. And finally, we propose the applicability of a post-polymerization processing step to increase the mechanical integrity to tissue level strength. Eventually, we hope to combine these results to develop a construct that closely mimics the properties and success of decellularized tissues in vivo.