June 2, 2026
Purdue researchers pioneer “outside-looking-in” neural interface using DNA nanotechnology
Researchers at Purdue University have developed synthetic DNA origami tiles that self-insert into live neuronal membranes to form stable nanopores, enabling scientists to record intracellular electrical activity and deliver drugs directly into targeted neurons — without damaging the cell membrane. Published in Nature Nanotechnology, this “outside looking in” approach opens a new paradigm for long-term, high-fidelity neural interfaces and precisely targeted therapies for neurological disease.