If you’ve been around BME during this past year, you may have heard about the EMBRIO Institute. Led by BME Head, David Umulis, EMBRIO is Emergent Mechanisms in Biology of Robustness, Integration, and Organization Institute. Funded in late 2021 as an NSF Biology Integration Institute, EMBRIO aims to determine how living systems integrate “orthogonal” signals such as chemical and mechanical stimuli to develop responsive phenotypes that coordinate cell and tissue structures for survival and function. We are employing quantitative imaging and simulation to bridge diverse biological systems to penetrate a Rules of Life question—"How are multimodal signals integrated across scales to coordinate the robust cell biological and morphogenetic responses needed to survive?”. EMBRIO’s interdisciplinary team is ideally positioned to penetrate these problems with expertise in modeling, simulation, experimental biology, and educational research. The answers to these questions have implications for human health and longevity.