A recent article, entitled "Controllable Self-Assembly of Nanoparticles for Specific Delivery of Multiple Therapeutic Molecules to Cancer Cells Using RNA Nanotechnology," was showcased in Nano Letters, a journal of the American Chemical Society. The article described Guo's recent work that utilizes RNA nanotechnology to engineer both therapeutic siRNA and a receptor-binding RNA aptamer into molecules that hold promise for the repeated long-term treatment of chronic diseases by bypassing biological barriers to deliver multiple therapeutic agents directly to specific cells or tissues. Guo's work was supported by a DOD Breast Cancer Concept Award and a NIH Nanosciences and Nanotechnology in Biology and Medicine grant.

Human Gene Therapy also showcased Guo's work with Songchuan Guo, Nuska Tschammer and Sulma Mohammed as their cover story on "Specific Delivery of Therapeutic RNAs to Cells via the Dimerization Mechanism of phi29 Motor pRNA.

Detailed information on this research is available athttp://www.vet.purdue.edu/PeixuanGuo/