Awards and Honors

• Solomon R. Pollack Award for Excellence in Graduate Bioengineering Research, University of Pennsylvania, 5/2004

Selected Publications

• Rennier K, Ji JY. The role of death-associated protein kinase in endothelial apoptosis under fluid shear stress. Life Sciences. 93(5-6):194-200, 2013., 6/2013
• Nayebosadri A, Ji JY. Endothelial nuclear lamina is not required for glucocorticoid receptor nuclear import, but does affect receptor mediated transcription activation. AJP - Cell Physiology. 305(3):C309-22, 2013., 5/2013
• Mavi MF, Ji JY. Endothelial wound recovery is influenced by treatment with shear stress, wound direction, and substrate. Cell and Mol Bioeng. 6(3):310-325, 2013., 4/2013
• Rennier K, Ji JY. Effect of shear stress and substrate on endothelial DAPK expression, caspase activity, and apoptosis. BMC Research Notes. 6(1):10. 2013., 1/2013
• Nayebosadri A, Ji JY. Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement. Ann Biomed Eng. 40(7):1508-19, 2012., 1/2012
• Rennier K, Ji JY. Shear stress regulates expression of death-associated protein kinase in suppressing TNFα-induced endothelial apoptosis. J Cell Physiol. 227(6):2398-411, 2012. , 7/2011
• Ji JY, Verstraeten VL, Cummings KS, Lee RT, and Lammerding J. Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: Effects of farnesyltransferase inhibitors. Aging Cell 7(3):383-93, 2008., 2/2008
• Ji JY, Jing H, Diamond SL. Hemodynamic regulation of inflammation at the endothelial-neutrophil interface. Ann Biomed Eng. 36(4):586-95, 2008., 2/2008
• Ji JY, Lee RT, Vergnes L, Fong LG, Stewart CL, Reue K, Young SG, Zhang Q, Shanahan CM, and Lammerding J. Cell nuclei spin in the absence of lamin B1. J. Bio Chem. 282(27):20015-26, 2007. , 6/2007
• Lammerding J, Fong LG, Ji JY, Reue K, Stewart CL, Young SG, and Lee RT. Lamin A and lamin C but not lamin B1 regulate nuclear mechanics. J. Bio Chem. 281(35):25768-80, 2006., 9/2006

Expertise

Mechanotransduction, cell and nuclear mechanics, endothelial mechano-biology, biofluid mechanics, drug delivery, and biotechnology

Interests

Cells exist in a mechanically active environment. Our group is interested in understanding how various mechanical and biochemical signals can influence cell functions on a genetic, molecular, and cellular level; and how they are translated into tissue or whole body effects.