The human brain is the continuous subject of extensive investigation aimed at understanding its behavior and function. Despite an overwhelming interest and major research initiatives on how our brain operates, comparatively little is known about how it functions at the mechanical level. Recent findings have directly linked major brain development, mechanisms, and diseases to the mechanical response of the brain both at the cellular and tissue levels. Despite clear evidence that mechanical factors play an important role in regulating brain activity, current research efforts focus mainly on the biochemical or electrophysiological activity of the brain, mostly due to the difficulty of probing the brain physically.