Abstract:

Arthroprosthetic metal exposure has been linked to local and systemic dysfunctions, but critical gaps remain in our understanding of its effects. Evidence on the systemic distribution, local accumulation, and the physicochemical characterization of wear particles, specifically regarding size and elemental composition, is largely unknown. Additionally, the local effects of exposure under different scenarios, such as periprosthetic osteolysis, T-cell-mediated aseptic inflammation, and the role of degradation products in the onset of periprosthetic joint infections (PJI) are poorly understood. In this seminar, Dr. Schoon will present recent findings on exposure to arthroprosthetic metals. This includes a clinical study analyzing multi-metal levels in cerebrospinal fluid and blood from patients with arthroplasty implants and the characterization of arthroprosthetic wear particles in human tissue using advanced imaging techniques, including synchrotron-based methods. His work on the biological consequences of exposure to degradation products from metallic biomaterials primarily focuses on the impact of metal ions and particles on bone homeostasis and their influence on the functionality of immune cells following infection with PJI-relevant bacteria. The overall aim of his work is to optimize patient safety in orthopedic surgery and contribute to the development of next-generation orthopedic implants.

Biography:

Dr. Janosch Schoon is a group leader and head of experimental research in the Center for Orthopedics, Trauma Surgery and Rehabilitation Medicine at the Medical University of Greifswald in Germany. His research spans orthopedic biomaterial implants, tissue engineering, and in vitro humanized models of implant associated inflammation and cellular processes. He has a background in Applied Chemistry, Clinical Pharmacology and Toxicology, and received his PhD in basic medical research at the Charité Medical University in Berlin. Dr. Schoon received the Basic Research Award from the German Society for Arthoplasty, and the Heinz-Mittelmeier Research Award from the German Society for Orthopedics and Orthopedic Surgery.

~ BME Host: Taimoor H. Qazi ~

ZOOM link: https://purdue-edu.zoom.us/j/92232268789