Abstract:  Generating complex tissues has been an increasing focus in tissue engineering and regenerative medicine.  With recent advances in bioprinting technology, our laboratory has focused on developing platforms for treating and understanding clinically relevant problems ranging from congenital heart disease to orthopedic trauma.  In this presentation, we focus on engineering both orthopedic and gynecological tissues.  We utilize digital light processing (DLP)-based and extrusion-based additive manufacturing to generate engineered tissues.  Both approaches begin with CAD models that are then transferred to printing platforms.  Prints use a variety of inks, including synthetic (PEG) and natural (GelMA, ECM) materials.  Evaluation of printed constructs assesses critical criteria, including print fidelity, material properties (immediately after printing and at longer time points), cell viability, and cell functionality.  Tissue function is assessed both in vitro and in vivo.  This presentation will cover the diverse range of materials and processes developed in our laboratory and their application to relevant, emerging problems in tissue engineering. 

Biography:  Dr. John P. Fisher is a Distinguished University Professor, MPower Professor, Distinguished-Scholar Teacher, Fischell Family Distinguished Professor, and Department Chair in the Fischell Department of Bioengineering at the University of Maryland.  Dr. Fisher is also the Director of the Center for Engineering Complex Tissue (CECT), which aims to create a broad community focusing on 3D printing and bioprinting for regenerative medicine applications.  As the Director of the Tissue Engineering and Biomaterials Laboratory, Dr. Fisher’s group investigates biomaterials, stem cells, bioprinting, and bioreactors for regenerating lost tissues, particularly bone, cartilage, and cardiovascular tissues.  Dr. Fisher has been elected Fellow of the American Institute for Medical and Biological Engineering (2012), the Biomedical Engineering Society (2016), the International Academy of Medical and Biological Engineering (2020), and the International Union of Societies for Biomaterials Science and Engineering (2024).  Dr. Fisher is currently the Editor-in-Chief of the journal Tissue Engineering. 

~ BME Host: Taimoor H. Qazi ~ 

Historic Quote of the Week: "The first step in learning something new is to describe it first in words." - Leslie A. Geddes, founder of BIomedical ENgineering at PUrdue, est. 1974

ZOOM LINK: https://purdue-edu.zoom.us/j/93455052114 

*Note: Students registered for the seminar are expected to attend in-person.