Abstract: Obtaining high resolution images in scattering tissue has been a long-standing challenge in microscopy. This challenge is exacerbated when high frame rates are required, or when 3D imaging is required over extended volumes. I will present several tools we have developed to address this challenge. These can be applied to a variety of microscopy modalities ranging from multiplane imaging with speckle, to multi-focus confocal imaging with targeted illumination, and finally to multiphoton imaging. Our main applications are in-vivo imaging in the mouse brain, where we demonstrate high contrast kHz-rate imaging of neuronal electrical activity and blood flow deep in tissue.

Biography:  Jerome Mertz received an AB in physics from Princeton University in 1984, and a PhD in quantum optics from UC Santa Barbara and the University of Paris VI in 1991. Following postdoctoral studies at the University of Konstanz and at Cornell University, he became a CNRS research director at the Ecole Supérieure de Physique et de Chimie Industrielle in Paris. He is currently professor of Biomedical Engineering at Boston University. His interests are in the development and applications of novel optical microscopy techniques for biological imaging. He is also author of a textbook titled "Introduction to Optical Microscopy, 2nd Ed". https://sites.bu.edu/biomicroscopy/

~ BME Host: Krishna Jayant ~

ZOOM LINK https://us02web.zoom.us/j/89944020354?pwd=V3l6eGx4TTE1ak5oZmF3V0g4WG5qUT09

*Students registered for the seminar are expected to attend in-person.