Associate Professor of Chemical Engineering
School of Chemical Engineering
Forney Hall of Chemical Engineering
480 Stadium Mall Drive
West Lafayette, IN 47907-2100
- "Laterally-Mobile Mixed Polyelectrolyte/Polymer Brushes": Understanding the behavior of polymers end-grafted to a surface is fundamental to many technological applications of polymers, including colloidal stabilization, membrane surface modification, ion-exchange adsorbents, lubricative coating, and the creation of surfaces with externally tunable properties. In this project, using a combined theoretical and experimental approach, we investigate novel mixed polymer brush systems, namely, the mixed brushes composed of laterally-mobile polyelectrolyte and non-charged polymer chains. This novel mixed brush system offers previously unavailable opportunities (i) to produce mesoscopic surface patterns of various length scales by long-range-frustrated lateral phase separation between the two chain types and (ii) to create functional interfaces with surface properties switchable between charged and non-charged states.
- "Multicomponent Polymer/Micelle-Based Gene Delivery": Gene therapy holds great promise as a treatment for genetic diseases such as cystic fibrosis, sickle cell anemia, and Huntingtons disease. However, a method for safe and efficient in vivo gene delivery into the targeted cells is presently a major limiting factor. Our interdisciplinary collaborative research efforts currently explore new approaches for improving in vivo DNA/siRNA delivery using two new classes of polymeric materials: (i) triblock copolymer micelle nanoparticles, and (ii) intracellularly degradable polycations.
- "Guided Assembly of Colloids at Solid-Liquid and Liquid-Gas Interfaces": High-quality two-dimensional (2D) colloid crystals have potential utility in many technological applications, for instance, as surface templates for epitaxially growing 3D colloid photonic crystals, as structural elements for modulating the surface plasmon properties of materials, and as mold structures for fabricating microlens. Therefore, precise and economical fabrication of 2D colloid crystals presents essential opportunities for advancement of these technologies. In this project, we explore a new method of fabricating highly-ordered 2D colloid crystals with non-closed-packed symmetries with unprecedented efficiency and precision.
- Hoyoung Lee
- Vasilios Tsouris
- Jae Sung Lee
- Nicholas W. Brandon
- Mina Dimitri
- Jayme W. Khoo
- Daniel P. Logsdon
- Kee-Koon Ng
- Gregory E. Mohr
- Victoria Tandiono
- Sean R. Upchurch
Awards and Honors
“In Situ-Polymerized Carbon Nanotube/Polyimide Nanocomposites: Effect of Reaction Stoichiometry on the Glass Transition Properties of the Nanocomposites,” D. H. Kim, and Y.-Y.Won, Macromolecular Reaction Engineering, 6 (1), 45-56 (2012)
“Confinement Induced Lateral Segregation of Polymer Coated Nanospheres,” R. Nap, Y-Y. Won, and I. Szleifer, Soft Matter, 8 (5), 1688-1700 (2012)
“Preparation of Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micelles,” D. H. Kim, A. Wei, and Y.-Y. Won, ACS Applied Materials & Interfaces, 4(4), 1872-1877 (2012)
“A Study of the Air-Water Interfacial Properties of Biodegradable Polyesters and Their Block Copolymers with Poly(ethylene glycol): Toward Rational Design of a Polymeric Lung Surfactant,” H. W. Park, J. Choi, K. Ohn, H. Lee, J. W. Kim, and Y.-Y. Won, Langmuir, 28(31), 11555-11566 (2012)
“Poly(ethylene oxide) Chains Are Not “Hydrophilic” When They Exist as Polymer Brush Chains: A Conclusion Drawn from a Self-Consistent Field Theory-Based Analysis of Neutron Reflectivity and Surface Pressure-Area Isotherm Data,” H. Lee, D. H. Kim, K. N. Witte, K. Ohn, J. Choi, B. Akgun, S. Satija, and Y.-Y. Won, Journal of Physical Chemistry B, 116(24), 7367–7378 (2012)
“Reduced Water Density in Poly(ethylene oxide) Brushes,” H. Lee, D. H. Kim, H.-W. Park, K. Kim, M. Meron, B. Lin, and Y.-Y. Won, Journal of Physical Chemistry Letters, 3, 15891595 (2012)
“A Discussion of the pH-Dependent Protonation Behaviors of Poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) and Poly(ethylenimine-ran-2-ethyl-2-oxazoline) (P(EI-r-EOz)),” H. Lee, S. H. Son, R. Sharma, and Y.-Y. Won, Journal of Physical Chemistry B, 115(5), 844-860 (2011)
“Influence of Nano-Carrier Architecture on In Vitro siRNA Delivery Performance and In Vivo Biodistribution: Polyplexes vs. Micelleplexes,” D. J. Gary, H. Lee, R. Sharma, J.-S. Lee, Y. Kim, Z. Y. Cui, D. Jia, V. D. Bowman, P. R. Chipman, L. Wan, Y. Zou, G. Mao, K. Park, B.-S. Herbert, S. F. Konieczny, and Y.-Y. Won, ACS Nano, 5 (5), 3493-3505 (2011)
Recent Invited Lectures"Triblock Copolymer Micelle-Based DNA/siRNA Delivery," Departmental Seminar, Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, April 22, 2008. "Triblock Copolymer Micelle-Based DNA/siRNA Delivery," Departmental Seminar, Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, February 28, 2008. "Triblock Copolymer Micelle-Based DNA/siRNA Delivery," Departmental Seminar, Department of Chemistry, University of Memphis, Memphis, TN, November 30, 2007. "Polymer Nanoparticle-Based Gene Delivery," KIChE-US Chapter Outstanding Young Investigator Award Seminar, Open Forum for Korean American Chemical Engineers, AIChE Annual Meeting, Salt Lake City, UT, November 7, 2007. "Triblock Copolymer Micelle-Based DNA/siRNA Delivery," Departmental Seminar, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, November 5, 2007. "Mixed Polyelectrolyte and Neutral Polymer Brushes: Fundamentals and Applications," 3M Tech Forum, 3M Company, St. Paul, MN, June 4, 2007. "Mixed Polyelectrolyte and Neutral Polymer Brushes: Fundamentals and Applications," Medtronic Forum, Medtronic Inc., Minneapolis, MN, June 5, 2007.