Assistant Professor of Chemical Engineering
School of Chemical Engineering
Forney Hall of Chemical Engineering
480 Stadium Mall Drive
West Lafayette, IN 47907-2100
Our research integrates engineering principles, polymer physics, nanotechnology and biology to create new technologies and investigate biological phenomena at the molecular level.
Biomimetic Nanoparticle System
The advancement of nanotechnology has enabled us to create biomimetic systems with equivalent complexity yet more controlled features compared with real biological systems. We engineer nanoparticle based systems, applying biological and physical principles. Exploiting these systems can lead to solutions to many challenging biological problems. Specifically, systems resembling the DNA packaging in eukaryotic cells will be developed and used as a tool to study the epigenetic phenomena.
The key to understand biological phenomena is to elucidate the interactions of vital biological molecules, i.e. protein, DNA and RNA. These interactions can be explored at various length and time scales with fluorescent microscope and micro-rheological experiments. We combine theoretical study with experiments to identify and predict these interactions, particularly at the molecular level during chromatin silencing process. The findings can benefit and lead to new designs of future drug target and genetic therapy.
- Seong-eun Kim
- Agnes Mendonca
- Nathan Nurse
- Oscar Sanchez Medina
Awards and Honors
"Unmethylated and methylated CpG dinucleotides distinctively regulate the physical properties of DNA," I. Jimenez-useche, D. Shim, J. Yu, C. Yuan, Biopolymers, accepted
"DNA methylation regulated nucleosome dynamics," I. Jimenez-Useche, J. Ke, Y. Tian, D. Shim, S. C. Howell, X. Qiu, C. Yuan, Scientific Reports, 2013, 3: 2121
"Elucidating internucleosome interactions and the roles of histone tails," S. C. Howell, K. Andreson, I. Jimenez, C. Yuan, X. Qiu, Biophysical J., 2013, 105:194-199
"Histone H3 and H4 tail clipping affects the nucleosome dynamics," N. Nurse, I. Jimenez-Useche, I. T. Smith, C. Yuan, Biophysical J., 2013:104:1-8
"The effect of DNA CpG methylation on the dynamic conformation of a nucleosome," I. Jimenez-Useche, C. Yuan, Biophysical J., 2012,103:1-11
"Controlled synthesis of hierarchical NiO nanosheet hollow spheres with enhanced supercapacitive performance," S. Ding, T. Zhu, J. S. Chen, Z. Wang, C. Yuan, X. W. Lou, J. Material Chemistry, 2011, 21:6602-6606
"DNA bending stiffness on small length scales," C. Yuan, H. Chen, X. W. Lou, L. A. Archer, Phys. Rev. Lett., 2008, 100, 018102
"T4 DNA ligase is more than an effective trap of cyclized product," C. Yuan, X. W. Lou, E. Rhoades, H. Chen, L. A. Archer, Nucleic Acids Res., 2007, 35, 5294-5302
"Spontaneous sharp bending of DNA: role of melting bubbles," C. Yuan, E. Rhoades, X. W. Lou, L. A. Archer, Nucleic Acids Res., 2006, 16, 4554-4560
"Comprehensive interpretation of gel electrophoresis data," C. Yuan, E. Rhoades, D. M. Heuer, S. Saha, X. W. Lou, L. A. Archer, Analytical Chemistry, 2006, 78, 6179-6186