Assistant Professor of Chemical Engineering
School of Chemical Engineering
Forney Hall of Chemical Engineering
480 Stadium Mall Drive
West Lafayette, IN 47907-2100
Our research integrates engineering principles, polymer physics, nanotechnology and biology to create new technologies and investigate biological phenomena at the molecular level.
Biomimetic Nanoparticle System
The advancement of nanotechnology has enabled us to create biomimetic systems with equivalent complexity yet more controlled features compared with real biological systems. We engineer nanoparticle based systems, applying biological and physical principles. Exploiting these systems can lead to solutions to many challenging biological problems. Specifically, systems resembling the DNA packaging in eukaryotic cells will be developed and used as a tool to study the epigenetic phenomena.
The key to understand biological phenomena is to elucidate the interactions of vital biological molecules, i.e. protein, DNA and RNA. These interactions can be explored at various length and time scales with fluorescent microscope and micro-rheological experiments. We combine theoretical study with experiments to identify and predict these interactions, particularly at the molecular level during chromatin silencing process. The findings can benefit and lead to new designs of future drug target and genetic therapy.
- Agnes Mendonca
- Nathan Nurse
- Oscar Sanchez Medina
Awards and Honors
"DNA methylation regulated nucleosome dynamics," I. Jimenez-Useche, J. Ke, Y. Tian, D. Shim, S. C. Howell, X. Qiu, and C. Yuan, Biophysical Journal, in press (2014)
"Lipase-catalyzed Process for Biodiesel Production: Protein Engineering and Lipase Production," H. T. Hwang, Q. Feng, C. Yuan, X. Zhao, D. Ramkrishna, D. Liu, and A. Varma, Biotechnology and Bioengineering, 111, 639-653 (2014)
“One-pot Approach for Examining the DNA Methylation Patterns Using an Engineered Methyl-probe,” S. K. Kim, C. Matthew, and C. Yuan, Biosensors and Bioelectronics, 58, 333-337 (2014)
"Unmethylated and Methylated CpG Dinucleotides Distinctively Regulate the Physical Properties of DNA," I. Jimenez-useche, D. Shim, J. Yu, and C. Yuan, Biopolymers, 101, 517-524 (2014)
“Solution Scattering and FRET Studies on Nucleosomes Reveal DNA Unwrapping Effects of H3 and H4 Tails,” K. Andresen, I. Jimenez-Useche, S. Howell, C. Yuan, and X. Qiu, PLoS ONE, 8(11), e78587 (2013)
"Elucidating Internucleosome Interactions and the Roles of Histone Tails," S. C. Howell, K. Andreson, I. Jimenez, C. Yuan, and X. Qiu,Biophysical J., 2013, 105:194-199
"Histone H3 and H4 Tail Clipping Affects the Nucleosome Dynamics," N. Nurse, I. Jimenez-Useche, I. T. Smith, and C. Yuan, Biophysical J., 2013:104:1-8
"The Effect of DNA CpG Methylation on the Dynamic Conformation of a Nucleosome," I. Jimenez-Useche, and C. Yuan, Biophysical J., 2012, 103:1-11