Pharma LPRC – CIPHER: Cellular Immuno-engineering, Physiological systems, and Healthcare-driven Research
CIPHER aims to advance next-generation immunotherapies for difficult-to-treat diseases, including cancer and neurological disorders, by combining immunoengineering with advanced manipulation of the immune system for therapeutic use. Through the design and analysis of cellular and tissue systems and models, including immune cells and their interactions with tissues and diseases, the research seeks to deepen understanding of immune function and enhance therapeutic efficacy. In parallel, the project develops physiologically relevant organoid systems, including brain-like tissues, to study interactions between engineered immune cells and complex disease microenvironments. Together, these complementary approaches provide a robust framework for uncovering disease mechanisms, optimizing immune-based strategies, and accelerating the translation of innovative therapies.
Fall 2026
Sandro Matosevic
West Lafayette