Abstract: Background Many molecules are flexible and undergo significant shape deformation as part of their function, and yet most existing molecular shape comparison (MSC) methods treat them as rigid bodies, which may lead to incorrect shape...
![Using Diffusion Distances for Flexible Molecular Shape Comparison](https://engineering.purdue.edu/cdesign/wp/wp-content/uploads/2010/10/diffusion-1080x481.jpg)
Abstract: Background Many molecules are flexible and undergo significant shape deformation as part of their function, and yet most existing molecular shape comparison (MSC) methods treat them as rigid bodies, which may lead to incorrect shape...
Abstract: During the past decade, the computed tomography has been successfully applied to various fields especially in medicine. The estimation of view angles for projections is necessary in some special applications of tomography, for example,...
Abstract:  Product design is one of the most important sectors influencing global sustainability, as almost all the products consumed by people are outputs of the product development process. In particular, early design decisions can have a very...
Abstract: As the description of design requirements at the earlier design stage is inaccurate and vague, it is difficult to figure out functional structure of a product and make sense product configuration. Therefore, it plays an important role to...
Abstract: Understanding the limits of a design is an important aspect of the design process. When mathematical models are constructed to describe a design concept, the limits are typically expressed as constraints involving the variables of that...
Abstract: Over the past few years, academic institutions have become aware of the importance of innovation in education, as well as its broader role in strengthening the economy. Creativity and innovative thinking are not easily taught in the...
Abstract: As customer preference is viewed as a reflection of desires for product features and even future product opportunities, it is crucial for the generation of design concepts. In this paper, a six-stage methodology is described for...
Abstract: The issue of environmental sustainability, which is unprecedented in both magnitude and complexity, presents one of the biggest challenges faced bymodern society. Design engineers can make significant contributions by...
Abstract: Analysis of mesh models is gaining prominence as it has wide range of applications from engineering to medicine. In this paper, we present a method for analyzing meshes through the abstraction of its prominent cross-sections (PCS). An...
Abstract: The cost and environmental impacts of a product are largely determined during conceptual design. Most often, due to cost and time limitations, only a limited set of design concepts are carried forward for detailed design. As a result,...