The ACME² laboratory is equipped with four computer-controlled electro-hydraulic test machines (with various load capacities - 1,000; 5,500; 11,000; and 22,000 lb) and associated equipment are used to measure failure loads and to study fatigue crack formation and propagation in test specimens subjected to simulated aerospace load/temperature/time histories. One of the load frames is outfitted with a tube furnace capable of achieving 1600 °C with tailorable gas environments, including steam environment.  Another load frame has a box furnace capable of achieving 1600 °C with tailorable gas environments and the third load frame has an induction heater in open air and a split shell furnace.  Two portable (1,000 lb capacity) load-frames allow in situ experiments (i) for high energy diffraction microscopy and (ii) within a scanning electron microscope chamber with electron back-scattering diffraction capabilities.  For each in situ set-up, strain field mapping with digital image correlation equipment is available.  Additionally, for material characterization purposes, the lab is equipped with an optical BX51 Olympus microscope with motorized stage and automated image stitching, ZeGage 3D Optical Profiler providing 5 nm resolution with automated stage, Keyence VHX 7000 digital microscope, FLIR infrared camera rated to 1500 °C with 3 μm resolution. Hence, our facilities are well equipped to study the fatigue response of a material by controlling forces with high resolution.