Interdisciplinary Training Program in Auditory Neuroscience (TPAN)
There is a national need to advance the understanding of hearing in both healthy patients and those with various causes of hearing loss. The objective of this training program is to train the next generation of faculty who could populate colleges of science, engineering, and health sciences, as well as to send graduates into industry prepared to work toward creative solutions for treating hearing loss.
Specifically, in order to advance auditory neuroscience training, this graduate program leverages faculty expertise in basic hearing science and technology development, from three Purdue University colleges (Science, Engineering, and Health & Human Sciences) and 6 doctoral admissions programs. Two types of investigators are included in the training program: 11 hearing scientists with focused research programs related to auditory system neuroscience, and 8 technology innovators who are trained in other disciplines (electrical, computer and biomedical engineering, and chemistry).
Collectively and collaboratively, the program will expand knowledge about mechanisms at the molecular, cellular and systems levels that underlie auditory information processing. This fundamental knowledge can then be applied to better understand the changes that lead to pathologies of the auditory system due to damage, disease, aging, and congenital disorders, as well as understanding how hearing evolved and influences behavior and natural selection. Technological approaches to these questions include, but are not limited to, fluorescent sensors to detect purinergic signaling in the intact nervous system, biological implants for neuromodulation, high-resolution four-dimension calcium imaging deep in the mammalian brain, optogenetics and robotics (automated patch-clamping) for brain circuit analysis, and multimodal brain imaging methods.
This training program is unique in that it is specifically designed to serve students with undergraduate degrees in the disparate disciplines of life science, physical science or engineering, and merge them into a unified cohort focused on auditory neuroscience. Students will be selected for a 2-year term on the training grant, beginning at the start of their second (or third) year. The training curriculum includes 4 core courses (one each in neuroscience, the auditory periphery, central/perceptual aspects of hearing, and signal processing), several recommended courses (e.g., in neurosurgery or neuroscience), a weekly Hearing Science seminar series, and yearly attendance at extramural hearing-related courses and/or auditory neuroscience conferences. In addition to administrative support for the program, the Purdue Institute for Integrative Neuroscience will provide students with additional resources, such as supervised grant writing, hands-on training in animal behavior and human stem cells, annual neuroscience retreats, and access to in-house competitions for travel grants and pilot funding for collaborative projects. Further, this program builds on Purdue’s extensive history in training graduate students in collaborative research (particularly in hearing science and technology development), and preparing these students for successful research careers in academia, industry and the clinic.
Meet our First T32 Fellows
Matt received is B.S. in mechanical engineering from Indiana University-Purdue University, Fort Wayne and his M.S. in biomedical engineering from Purdue. He is now a Ph.D. student studying early signals guiding cochlea development from a systems biology approach using quantitative fluorescent imaging data to inform, validate, and characterize dynamical models of biochemical networks. Outside time spent on research, he enjoys life with his wife, one-year-old daughter, and friends.
Hearing science is not where I imagined ending up as an undergraduate, but the indirect path I took to developing an interest in quantitative biology research has introduced me to a fascinating and highly complex system that’s the subject of a diverse range of research at Purdue. The hearing science community is spectacular, and faculty demonstrate genuine interest in students’ success. This is made clear through their talented teaching, involved mentorship, and approachable demeanor. Acceptance into the TPAN has helped me to gain a much broader and more complete understanding of the context in which the subject of my project sits that I would not have benefited from outside the program.
Ravinderjit is a third year student in the medical scientist training program (MSTP), a dual degree program (MD & PhD) between IU and Purdue. He received his B.S. in Electrical Engineering at Georgia Tech in Atlanta, Georgia. Ravinderjit is interested in better understanding the mechanisms of auditory source separation and binaural hearing. Ravinderjit works with both the SNAP Lab and the Brainstem Neurophysiology Lab to combine perceptual, EEG, and single unit data to study the phenomena mentioned before. In his spare time, Ravinderjit enjoys playing basketball and watching college and professional sports.
One aspect of the TPAN that I have very much enjoyed is how it helped immerse me into the hearing community at Purdue. I am personally interested in the sensory encoding of hearing in the nervous system, but at Purdue, hearing is studied in many other ways than just that. The exposure to the diverse types of hearing research going on at Purdue has helped me better understand my own work as well as inform new ideas and projects I can pursue.