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Seminars in Hearing Research (3/31/22) - Wei-Ming Yu

Author: M. Heinz
Event Date: March 31, 2022
Hosted By: Hari Bharadwaj
Time: 1030-1120
Location: LYLE 1150
Contact Name: Bharadwaj, Hari M
Contact Email:
Open To: All
Priority: No
School or Program: Biomedical Engineering
College Calendar: Show
Wei-Ming Yu (Professor of Biology, Loyola University) will present "Ephrin-Eph forward signaling in tonotopic map formation in the mouse cochlear nucleus" at our next Seminars in Hearing Research at Purdue (SHRP) on March 31st at 1030-1120 in LYLE 1150.

Seminars in Hearing Research at Purdue (SHRP)


Seminar presented in conjunction with the Purdue Biological Sciences Seminar Series (Neurobiology & Physiology Area).


Date: Thursday, March 31,  2022


Time: 10:30 – 11:20 am

Location: Zoom only


Zoom info:

Meeting ID: 931 0815 8900 

Passcode: 11501150


Speaker: Wei-Ming Yu, Ph.D., Loyola University, Chicago, IL

Host: Donna M. Fekete, Ph.D., Purdue University


Title: Ephrin-Eph forward signaling in tonotopic map formation in the mouse cochlear nucleus 

Abstract:  Tonotopy is a fundamental feature of the vertebrate auditory system and forms the basis for sound discrimination, but the molecular basis underlying its formation remains largely elusive. Ephrin/Eph signaling is known to play important roles in topographic mapping in other sensory systems. Here, we found that ephrin-A3 molecules are differentially expressed along the tonotopic axis in developing mouse cochlear nucleus. Ephrin-A3 forward signaling is sufficient to repel auditory nerve fibers in a developmental stage-dependent manner. In ephrin-A3 mutant animals, the tonotopic map is degraded and isofrequency bands of neuronal activation upon pure tone exposure become imprecise in the anteroventral cochlear nucleus. Ephrin-A3 mutant mice exhibit a delayed second wave in auditory brainstem responses and impaired detection sound frequency changes. Our findings establish an essential role of ephrin-A3 forward signaling in forming precise tonotopy in the mouse cochlear nucleus to ensure accurate sound discrimination.




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