Dr. Lefteri Tsoukalas is recipient of the Humboldt Prize and an internationally renowned expert in signal processing algorithms applied to nuclear materials detection and non-proliferation, smart sensor development and advanced measurement techniques. He has extensive experience as a safeguards engineer and as a nuclear instrumentation and controls specialist and has served in several advisory and consulting positions for national and international regulatory agencies. He has more than 25 years of accumulated experience as project manager of competitively funded projects sponsored, among others, by NNSA, NRC, DOD, DOE and EPRI. His research covers both experimental and model development studies, signal processing techniques, including cutting edge multi-variant statistical methods, Gaussian processes for background estimation, wavelet analysis and Hilbert-Huang transforms.