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Linnes Lab

Publications

A full list of publications and citation statistics for Dr. Jacqueline C. Linnes is provided on Google Scholar.

Peer Reviewed Publications

  1. A Enriguez, JY Park, DH Lee, C Russell, U Raipancholia, A Ahrens, JC Linnes, ST Wereley, H Lee. "Magnetic microactuator embedded electrochemical sensing platform towards on-demand sensor cleaning", Sensors and Actuators B: Chemical, 424, 136715 (2025). doi: 10.1016/j.snb.2024.136715
  2. KA Buatista, E Madsen, SD Riegle, JC Linnes+. "HELPStat: A Handheld, EIS-Enabled, Low-Cost, and Portable Potentiostat", ACS Electrochemistry, 2024. doi:10.1021/acselectrochem.4c00052
  3. DH Lee, E Nwanochie, KN Clayton, ST Wereley, TL Kinzer-Ursem, JC Linnes+. "Real-time Visualization of HIV-1 RNA Detection Using Loop-Mediated Isothermal Amplification-Enabled Particle Diffusometry", ACS Sensors, 9, 5541-5549 (2024). doi: 10.1021/acssensors.4c01870
  4. JC Linnes, E Moore, A Porras, E Wayne, P Boyle, L Chow, K Maisel, S Peyton, S Stabenfeldt, K Stevens, E Jergans, R Willits. “Framework for department-level accountability to diversify engineering”, Nature Reviews Bioengineering, 2, 521–530 (2024). doi: 10.1038/s44222-024-00183-4
  5. H Ma, ST Wereley, JC Linnes+, TL Kinzer-Ursem+. “Computational fluid dynamics method for determining the rotational diffusion coefficient of cells”, Physics of Fluids 36, 042010 (2024) https://doi.org/10.1063/5.0193862
  6. H Ma, AA Ramanujam, JC Linnes+, TL Kinzer-Ursem+. “Biomolecular interaction analysis quantification with a low volume microfluidic chip and particle diffusometry”. Analytical Chemistry, 2024, 96, 15, 5815–5823 doi: 10.1021/acs.analchem.3c04840
  7. NDP Bluhm* GM Tomlin*, OS Hoilett*, EA Lehner, BD Walters, AS Pickering, KA Bautista, SL Bucher, JC Linnes+ “Preclinical Validation of NeoWarm, a Low-Cost Infant Warmer, in Hypothermic Piglets, and its Implications on Using Piglets as Models for Neonatal Hypothermia”, Frontiers in Pediatrics, 3 April, 2024 doi: 10.3389/fped.2024.1378008
  8. M Hui, TL Kinzer-Ursem, JC Linnes+. “A two-phase porous media flow model based on the incompressible Navier-Stokes equation”, Analytical Chemistry, Analytical Chemistry, 96, 13, 5265-5273 (2024) doi: 10.1021/acs.analchem.3c05982
  9. N Sritong, WW Ngo, KFK Ejendal, JC Linnes+. “Development of an Integrated Sample Amplification Control for Salivary Point-of-Care Pathogen Testing”, Analytica Chimica Acta, 2024 Jan 25: 1287:342072 doi: 10.1016/j.aca.2023.342072
  10. NM Rodriguez, L Balian, C Tolliver, I Kataki, J Rivera-De Jesus, JC Linnes. “Human-centered design of a smartphone-based self-test for HIV viral load monitoring”. Journal of Clinical and Translational Science, 2023. Nov 24;7(1):e262 doi: 10.1017/cts.2023.686
  11. C Mgawe, CS Likhovole, S Ger, E Odari, JC Linnes, BN Kanoi, J Gitaka, L Ochola+. “Application of multiple binding sites for LAMP primers across P. falciparum genome improves detection of the parasite from whole blood samples”. Frontiers in Malaria Journal, 2023. 1 doi:10.3389/fmala.2023.1303980
  12. Y Dai, J Nolan, E Madsen, M Fratus, J Lee, J Zhang, J Lim, S Hong, M Alam, JC Linnes, H Lee, CH Lee. “Wearable sensor patch with hydrogel microneedles for in-situ analysis of interstitial fluid”, ACS Applied Materials Interfaces, 2023. 15(49): 56760-56773, doi: 10.1021/acsami.3c12740
  13. OS Hoilett, J Ummel, L Schepers, A Soepritna, J Ma, A Fujita, A Pickering, B Walters, Co Goergen, JC Linnes+. “Opioid Overdose Detection in a Murine Model Using a Custom-Designed Photoplethysmography Device” Innovation and Research in BioMedical Engineering, 2023. 44(5); 100792, doi: 10.1016/j.irbm.2023.100792
  14. M Fratus, J Lim, J Nolan, E Madsen, Y Dai, CH Lee, JC Linnes, H Lee, MA Alam+. “Geometry-defined Response Time and Sensitivity for Microneedle-based Amperometric Sensors”, IEEE Sensors Journal, 2023, 23(13):14285-14294, doi: 10.1109/JSEN.2023.3277425
  15. A Desai, D Tankasala, GP Ng, PR Thakkar, OS Hoilett, K Mather, JC Linnes+, “Selective collection of exhaled breath condensate for non-invasive screening of breath glucose” Journal of Diabetes Science and Technology, 2023, 0(0): doi: 10.1177/19322968231179728
  16. NM Rodriguez, G Burleson, JC Linnes+, K Sienko+ “Thinking Beyond the Device: An Overview of Human- and Equity-Centered Approaches for Improved Health Technology Design”, Annual Review of Biomedical Engineering, 2023. 25: 257–79. doi: 10.1146/annurev-bioeng-081922-02483
  17. N Sritong, M Sala de Medeiros, LAW Basing, JC Linnes+, “Promise and perils of paper-based point-of-care nucleic acid detection for pandemic pathogens”, Lab on a Chip, 2023, 23, 888-912. doi: 10.1039/D2LC00554A
  18. DH Lee, KN Clayton, TL Kinzer-Ursem, JC Linnes, ST Wereley+, “Quantifying Brownian Motion in the Presence of Simple Shear Flow with Particle Diffusometry”, Experiments in Fluids, 2023, 64(2):26. doi: 10.1007/s00348-022-03566-8
  19. DH Lee, E Madsen, JC Linnes, ST Wereley+, “Temporally and spatially resolved micro-rheometry of a transient viscous polymer formation”, Measurement Science and Technology, 2022, Dec 21; 34:035301. doi: 10.1088/1361-6501/aca993
  20. JD Berwanger*, MA Lake*, HY Tan, S Ganguly, CJ Welch, JC Linnes, M Bruening+. “Microporous Affinity Membranes and their Incorporation into Microfluidic Devices for Monitoring of Therapeutic Antibodies”, Talenta, 2023, Jan 15; 252:123842. doi: 10.1016/j.talanta.2022.123842
  21. H Ma, ST Wereley, JC Linnes+, TL Kinzer-Ursem+. “Measurement of protein-protein interaction dynamics using microfluidics and particle diffusometry,” Analytical Chemistry, 2022, 94(45):15655–15662, doi: 10.1021/acs.analchem.2c02570
  22. EI Newsham, EA Phillips, H Ma, MM Chang, ST Wereley, JC Linnes+ “Characterization of wax valving and μPIV analysis of microscale flow in paper-fluidic devices for improved modeling and design” Lab Chip, June 2022, 22, 2741-2752, doi: 10.1039/D2LC00297C
  23. AJ Colbert, DH Lee, KN Clayton, ST Wereley, JC Linnes+, TL Kinzer-Ursem+. “PD-LAMP smartphone detection of SARS-CoV-2 on Chip” Analytica Chemica Acta. April 2022, 1203:339702. Doi: 10.1016/j.aca.2022.339702
  24. JJ MacNeill, JC Linnes, RD Hubach, NM Rodriguez. "From crisis to crisis: impacts of the COVID-19 pandemic on people living with HIV and HIV/AIDS service organizations in Indiana”, BMC Health Services Research, 2022, 22(1):1-11, doi.org/10.1186/s12913-022-07998-0
  25. AE Lottes, KJ Cavanaugh Jr, YY-F Chan, VJ Devlin, CJ Goergen, R Jean, JC Linnes, M Malone, R Pea, DG Reuter, K Taylor, GR Wodicka. “Navigating the Regulatory Pathway for Medical Devices—a Conversation with the FDA, Clinicians, Researchers, and Industry Experts”.  Journal of Cardiovascular Translational Research, 2022, doi: 10.1007/s12265-022-10232-1
  26. E Nwanochie, JC Linnes+. “Review of Non-Invasive Detection of SARS-CoV-2 and Other Respiratory Pathogens in Exhaled Breath Condensate” Journal of Breath Research, 2022. Mar 18;16(2):10.1088/1752-7163/ac59c7. doi: 10.1088/1752-7163/ac59c7
  27. HY Tan, J Yang, JC Linnes, CJ Welch, ML Bruening+. “Quantitation of Trastuzumab and an Antibody to SARS-CoV‑2 in 2 Minutes Using Affinity Membranes in 96-Well Plates,” Analytical Chemistry, Jan 4, 2022. doi: 10.1021/acs.analchem.1c03654
  28. AJ Colbert, K Co, G Lima-Cooper, DH Lee, KN Clayton, ST Wereley, CC John, JC Linnes+, TL Kinzer-Ursem+. “Towards the use of a smartphone imaging-based tool for point-of-care detection of asymptomatic low-density malaria parasitaemia.” Malaria Journal. 2021 Sep 25;20(1):380. doi: 10.1186/s12936-021-03894-w
  29. MM Gilligan, JC Linnes, JE Von Oettingen, K Altenor+. “From Toy to Tool: Using Water Beads for Insulin Storage” Pediatric Diabetes, December 1, 2020 doi: 10.1111/pedi.13167
  30. TJ Moehling, DH Lee, ME Henderson, MK McDondald, PH Tang, ES Kim, ST Wereley, TL Kinzer-Ursem, KN Clayton+, JC Linnes+. “A Smartphone-Based Particle Diffusometry Platform for Sub-Attomolar Detection of Vibrio cholerae in Environmental Water”, Biosensors and Bioelectronics, 2020, 167, 112497; doi:10.1016/j.bios.2020.112497

  31. OS Hoilett, JF Walker, BM Doehrman, NJ Jaras, S Boppana, JC Linnes, "KickStat: A Versatile Miniaturized Potentiostat to Democratize Electrochemical Research," Sensors, 2020, 20(8), 2407; doi: 10.3390/s20082407

  32. LA Basing, SV Simpson, Y Adu-Sarkodie, JC Linnes, “A Loop-Mediated Isothermal Amplification (LAMP) assay for the detection of Treponema pallidum subsp. pertenue,” American Journal of Tropical Medicine & Hygiene, 2020, 103(1), 253; doi:10.4269/ajtmh.19-0243

  33. KM Byers*, AR Bird*, H Cho, JC Linnes, “Fully Dried ELISA with Novel Two-Dimensional Paper Network for Detection of Amplified Nucleic Acids”, ACS Omega, 2020, doi:10.1021/acsomega.0c00115

  34. KM Byers, LK Lin, L Stanciu, JC Linnes, “Versatile Printed Microheaters to Enable Low-Power Thermal Control in Paper Diagnostics,” The Analyst, 2020 Doi: 10.1039/c9an01546a

  35. EA Phillips*, TJ Moehling*, KFK Ejendal, OS Hoilett, KM Byers, LA Basing, LA Jankowski, JB Bennett, LK Lin, LA Stanciu, JC Linnes. "Microfluidic Rapid and Autonomous Analytical Device (microRAAD) to Detect HIV from Whole Blood Samples,” Lab on a Chip, 2019. Doi: 10.1039/C9LC00506D (*co-first authors)

  36. D Tankasala, JC Linnes+, “Non-Invasive Glucose Detection in Exhaled Breath Condensate,” Translational Research, 2019 Nov. 213:1-22 doi: 10.1016/j.trsl.2019.05.006

  37. B Dhowan, J Lim, MD MacLean, AG Bergman, MK Kim, Q Yang, J Linnes, CH Lee, CJ Goergen, H Lee. “Simple minimally-invasive automatic antidote delivery device (A2D2) towards closed-loop reversal of opioid overdose,” Journal of Controlled Release, 2019 May 31:306:130-137. Doi: 10.1016/j.jconrel.2019.05.041

  38. KN Clayton*, T Moehling*, S Wereley, JC Linnes+, T Kinzer-Ursem+, “Particle Diffusometry: An Optical Detection Method for Vibrio cholerae Presence in Environmental Water Samples,” Scientific Reports, 2019 Feb. 9:1739. Doi: 10.1038/s41598-018-38056-7 (*co-first authors, +co-corresponding authors)

  39. EA Phillips, T Moehling, A Ellington, S Bhadra, JC Linnes, “Strand displacement probes combined with isothermal nucleic acid amplification for instrument-free detection from complex samples,” Analytical Chemistry, 2018. 90(11): 6580–6586. Doi: 10.1021/acs.analchem.8b00269

  40. A Horst, NL Kolluri, JM Rosenbohm, J Hardick, C Gaydos, M Cabodi, CM Klapperich, JC Linnes, “A paper-fluidic platform to detect Neisseria gonorrhoeae in clinical samples,” Biomedical Microdevices, 2018. 20:2, 35-41. Doi: 10.1007/s10544-018-0280-x

  41. KN Clayton, G Berglund, JC Linnes, S Wereley, T Kinzer-Ursem. “DNA microviscosity characterization with particle diffusometry for downstream DNA detection applications”, Analytical Chemistry, 2017. Doi: 10.1021/acs.analchem.7b03513

  42. EA Phillips, S Zhao, R Shen, JC Linnes. "Thermally actuated wax valves for paper-fluidic diagnostics," Lab on a Chip, 2016. 16, 4230-4236. Doi:  10.1039/c6lc00945j

  43. JC Linnes, NM Rodriguez, L Liu, CM Klapperich. "Polyethersulfone improves isothermal nucleic acid amplification compared to current paper-based diagnostics," Biomedical Microdevices, 2016. 18 (2), 1-12. Doi: 10.1007/s10544-016-0057-z

  44. NM Rodriguez, JC Linnes, A Fan, CK Ellenson, CM Klapperich. “Paper-based RNA extraction, in situ isothermal amplification, and lateral flow detection for low-cost, rapid diagnosis of Influenza A (H1N1) from clinical specimens,” Analytical Chemistry, 2015. 87 (15), 7872-7879. Doi: 10.1021/acs.analchem.5b01594

  45. R Derda, J Gitaka, TM Kariuki, CM Klapperich, CR Mace, AA Kumar, M Lieberman, JC Linnes, J Nasimolo, J Ndung’u, E Taracha, A Weaver, DB Weibel, P Yager. “Enabling the development and deployment of next generation point of care diagnostics,” PLOS Neglected Tropical Diseases, 2015. 9 (5): e0003676. Doi:10.1371/journal.pntd.00036762015

  46. JC Linnes, A Fan, NM Rodriguez, B Lemieux, H Kong, CM Klapperich. “Paper-based molecular diagnostic for Chlamydia trachomatis,” RSC Advances, 2014. 4 (80), 42245 – 51. Doi: 10.1039/c4ra07911f

  47. P Vacas-Jacques, JC Linnes, A Young, V Gerrard, J Gomez-Marquez. “Portable digital lock-in instrument to determine chemical constituents with single-color absorption measurements for Global Health Initiatives,” Review of Scientific Instruments, 2014. 85 (3), 033103. Doi: 10.1063/1.4867097

  48. JC Linnes, SN Rudnick, GM Hunt, JJ McDevitt, EA Nardell. “Eggcrate UV: A whole ceiling upper-room ultraviolet germicidal irradiation system for air disinfection in occupied rooms,” Indoor Air, 2013. Doi: 10.1111/ina.12063

  49. S Miller, JC Linnes, J Luongo. “Ultraviolet germicidal irradiation: Future directions for air disinfection and building applications,” Photochemistry and Photobiology, 2013. 89(4) 777-81. Doi: 10.1111/php.1208

  50. JC Linnes, H Ma, JD Bryers. “Giant extracellular matrix binding protein gene and protein expression in Staphylococcus epidermidis is regulated by biofilm formation and osmotic pressure,” Current Microbiology, 2013. 66(6) 627-33. Doi: 10.1007/s00284-013-0316-7

  51. JC Linnes, K Mikhova, JD Bryers. “Adhesion of Staphylococcus epidermidis to biomaterials is inhibited by firbronectin and albumin,” Journal of Biomaterials Research Part A. 2013. 100(8) 1990-7. Doi: 10.1002/jbm.a.34036

  52. *D Alexander, *JC Linnes, S Bolton, T Larson. “Ventilated cookstoves improve respiratory health-related quality of life in rural Bolivia,” Journal of Public Health, 2013. 36 (3) 460-466 (*equal authorship) Doi: 10.1093/pubmed/fdt086

  53. J Callihan, R Roeder, LA Geddes, M Otlewski, A Kemeny. “Ventricular fibrillation frequency,” Pacing and Clinical Electrophysiology, 2006. 28(7) 610-612. Doi: 10.1111/j.1540-8159.2005.00166.x

Book Chapters

  1. JC Linnes, E Johansen, AA Kumar, “Incorporating the Needs of Users in the Development of Diagnostics for Global Health: A Framework and Two Case Studies", in Diagnostic Devices with Microfluidics. Ed. by F. Piraino and S. Selimovic. CRC Press, Boca Raton, FL 2017.

  2. JC Linnes, E Phillips, “Thermally Actuated Wax Vales for Multistep Diagnostics", in Diagnostic Devices with Microfluidics. Ed. by F. Piraino and S. Selimovic. CRC Press, Boca Raton, FL 2017.

  3. Y Fu, SH Jeong, J Callihan, J Kim, K Park, “Preparation of Fast-dissolving Tablets Based on Mannose”, in Polymeric Drug Delivery II, Ed. By S. Svenson. American Chemical Society, Washington DC 2006.

Conference Proceedings

  1. H Ma, ST Wereley, JC Linnes, TL Kinser-Ursem. “Measurement of kinetic constant of protein binding using microfluidics and particle diffusometry” 14th International Symposium on Particle Image Velocimetry. 2021 August 1-5, Virtual. DOI: 10.18409/ispiv.v1i1.75
  2. DH Lee, KN Clayton, TJ Moehling, TL Kinzer-Ursem, JC Linnes, ST Wereley. “Particle Diffusometry: PIV based method for Pathogen Detection on Smartphone-Based Platform. 13th International Symposium on Particle Image Velocimetry, 2021 July 22-24 Munich Germany.

  3. ND Bluhm, OS Hoilett, BD Walters, AS Pickering, JC Linnes, S Bucher. “NeoWarm: Kangaroo Mother Care with Continuous Temperature Tracking and Heating”, Proceedings of the 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2020 July 20-24, Montreal, Quebec, CN (Accepted)

  4. J Ummel, OS Hoilett, BD Walters, ND Bluhm, AS Pickering, D Wilson, JC Linnes. “Kick Ring LL: A Multi-Sensor Ring Capturing Respiration, Electrocardiogram, Oxygen Saturation, and Skin Temperature”, Proceedings of the 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2020 July 20-24, Montreal, Quebec, CN  (Accepted)

  5. OS Hoilett, AM Twibell, R Srivastava, JC Linnes. “Kick LL: A Smartwartch for Monitoring Respiration and Heart Rate using Photoplethysmography,” Proceedings of the 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2018 July 17-21; Honolulu, Hawaii, USA

  6. D Tankasala, GP Ng, MS Smith, JR Bendell, JC Linnes. “Selective Collection and Condensation of Exhaled Breath for Glucose Detection,” Proceedings of the 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2018 July 17-21; Honolulu, Hawaii, USA

  7. OS Hoilett, AF Aboelzahab, EA Layow, JC Linnes, CH Lee. “#FunTimesWithTheTA—A Series of Fun Supplementary Lessons for Introductory Level Biomedical Instrumentation Students, Part II (Work in Progress),” Proceedings of the 2018 ASEE Annual Conference & Exposition, 2018 June 24, Salt Lake City, UT, USA

  8. Q Yang, T Nguyen, C Liu, J Miller, J Rhoads, JC Linnes, H Lee. “Polyimide-Based Magnetic Microactuators for Biofouling Removal,” Proceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2016 August 16; Tampa, FL, USA

  9. OS Hoilett, AF Aboelzahab, EA Layow, JC Linnes, CH Lee. “#FunTimesWithTheTA—A Series of Fun Supplementary Lessons for Introductory Level Biomedical Instrumentation Students (Work in Progress),” Proceedings of the 2017 ASEE Annual Conference & Exposition, 2017 June 24, Columbus, OH, USA

  10. C Matlack, H Chizeck, T Davis, JC Linnes. “A Low-cost Solar Disinfection Indicator for Safe Water,” Proceedings of the 2011 IEEE Global Humanitarian Technology Conference, 2011. GHTC 283-286, Seattle, WA, USA

Issued Patents

  1. “Temperature controlled valves for paper-based microfluidic systems” US Patent. 12,111,529. JC Linnes, R Shen, M Chiu. Filed 04/14/2024. Issued 10/15/2024
  2. “Fluidic Control Elements for Readout Enhancement in two-dimensional paper networks (2DPN)” US Patent. 12,061,193. JC Linnes, LM Jamicich, EA Phillips, KM Byers, A Bird. Filed 06/02/2021. Issued 8/13/2024
  3. “Method of Monitoring Respiratory Rate In A Health Monitoring Device” US Patent. 11,633,152. JC Linnes, OS Hoilett, B Walters. Filed 10/16/2020. Issued 04/25/2023
  4. "Temperature Controlled Valves for Paper-based Microfluidic Systems” US Patent (method). 11,628,434. JC Linnes, R Shen, M Chiu. Filed 08/13/2021. Issued 04/18/2023
  5. “Method of Monitoring Respiratory Rate In A Health Monitoring Device” US Patent. 11,633,152. JC Linnes, OS Hoilett, B Walters. Filed 10/16/2020. Issued 04/25/2023
  6. "Temperature Controlled Valves for Paper-based Microfluidic Systems” US Patent (system). 11,529,626. JC Linnes, R Shen, M Chiu. Filed 10/26/2017. Issued 08/17/2021
  7. “Fluidic Control Elements for Signal Readout Enhancement In Two Dimensional Paper Networks” US Patent 11047853. JC Linnes, LM Jamicich, EA Phillips, KM Byers, AR Bird. Filed 01/19/2018. Published 07/19/2018. Issued 06/29/2021
  8. “Methods for Detecting Heart Rate, Respiration, Heart Rate, and Oxygen Saturation and Uses Thereof” US Patent 10,786,201. HW Lee, JC Linnes, OS Hoilett, AM Twibell, R Srivastava, R Lindsey, J Ummel. Filed 10/12/2018. Issued 9/29/2020
  9. “Temperature Controlled Valves for Paper-based Microfluidic Systems” US Patent. 11,090,649. JC Linnes, R Shen, M Chiu. Filed 10/26/2017. Issued 08/17/2021
  10. “Methods of measuring structural and functional changes of a biomolecular composition” US Patent. 11,221,287. ST Wereley, TL Kinzer-Ursem, KN Clayton, JC Linnes, D Lee, T Moehling. Filed 12/19/17. Issued 01/11/2022
  11. “Detection Device Having Capture Region and Detection Region” US Patent. 11136620B2. CM Klapperich, NM Rodriguez, JC Linnes. Filed 06/16/2016. Issued 10/05/2021
  12.  “Solar Disinfection of Fluid” US Patent. 9,868,651. CB Matlack, TB Davis, JC Linnes. Filed 12/29/2015. Issued 01/16/2018
  13. “Systems, devices and methods for multiplexed diagnostics” US Patent. 9,488,613. I Bosch, L Gherke, J Gomez-Marquez, K Hamad-Schifferli, NC Hanoumara, JC Linnes, DK Wood. Filed 08/30/2013. Issued 11/08/2016
  14. “Mannose based fast dissolving tablets" International Patent. JP 2004555820A. Y Fu, SH Jeong, J Kim, J Callihan, CM Pai, SY Park, G Seomoon, K Park, Filed 11/25/2003. Issued 09/29/2019
  • 3 Proprietary licenses assigned directly to company as part of research contracts