Amico presented a poster titled "Detecting local changes in structural connectomes after mild traumatic brain injury" at the annual meeting in Indianapolis. The meeting's topic was "Global to Local Health".

INTRODUCTION
The neuroscientific community is rapidly advancing towards the era of large public data repositories, the era of reproducibility of brain data and neuroscientific results and the exciting avenue of linking large-scale brain connectivity profiles to single subject’s clinical, demographical and behavioral features. In consequence, the emerging concept of "clinical connectomics" is becoming crucial when assessing neurodegenerative diseases. Here we propose a framework to investigate local differences in structural connectivity (SC) between healthy controls (HC, N=19) and traumatic brain injury patients (TBI, N=19). This approach is based on a Kolmogorov-Smirnov edgewise test between the control group and the TBI groups. We perform and evaluate these local abnormalities across six different diffusivity measures. This framework provides easy, fine-grained and mathematically grounded assessment of changes in individual brain connectivity due to structural damage and/or neurodegeneration.

The Indiana CTSI seeks to improve the health of individuals and communities by supporting highest-quality research and partnerships. We provide access to resources, services, training, education and funding opportunities.