Publications

Books

Park, K., Shalaby, S.W.S., and Park, H.: Biodegradable Hydrogels for Drug Delivery, Technomic Publishing Co., Inc., Lancaster, PA, 1993, 252 pages.

Ottenbrite, R., Hwang, S., and Park, K., Eds.: Hydrogels and Biodegradable Polymers for Bioapplications(ACS Symposium Series 627), American Chemical Society, Washington, DC, 1996, 268 pages.

Park, K., Ed.: Controlled Drug Delivery: Challenges and Strategies, American Chemical Society, Washington, DC, 1997, 629 pages.

Park, K. and Mrsny, R., Eds.: Controlled Drug Delivery: Designing Technologies for the Future (ACS Symposium Series 752), American Chemical Society, Washington, DC, 2000, 459 pages.

Park, K.D., Kwon, I.C., Yui, N., Jeong, S.Y. and Park, K., Eds.: Biomaterials and Drug Delivery toward New Millennium, Han Rim Won Publishing Co., Seoul, Korea, 2000, 691 pages.

Park, K. Ed., Protein- and Cell-Repellent Surfaces, Colloids and Surfaces B: Biointerfaces, Elsevier Science, Vol. 18 (No. 3-4), 2000.

Park, K., Ed., Recent Developments in Hydrogels, Advanced Drug Delivery Reviews, Elsevier Science,Vol. 54, 2001.

Yui, N., Mrsny, R., and Park, K., Eds.: Flash polymers and hydrogels: Understanding and designing the fast-responsive polymeric systems, CRC Press, Boca Raton, FL, 2004. 452 pages.

Morishita, M. and Park, K., Eds.: Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development, Informa Healthcare, New York, NY, 2009, 544 pages.

Wen, H. and Park, K, Eds.: Oral Controlled Release Formulation Design and Drug Delivery, John Wiley & Sons, New York, NY, 2010. 363 pages.

Park, K., Ed.: Biomaterials for Cancer Therapeutics, Woodhead Publishing Ltd., Oxford, UK, 2013, 528 pages.

Bae, Y.H., Mrsny, R., and Park, K., Eds.: Cancer Targeted Drug Delivery: An Elusive Dream, Springer, New York, 2013, 720 pages.

Hillery, A.M. and Park, K., Eds. Drug Delivery: Fundamentals and Applications, Second Edition, Taylor & Francis Group, New York, in press, 2016.



Digital Human

DHD2 is a multi-scale and multi-level project to simulate and predict biotransport kinetics of drugs and drug dosage forms. It evolves from collaborations among researchers in pharmaceutics, pharmacy, biomedical sciences, and mechanical engineering at Purdue University and Korea Institute of Science and Technology (KIST)
Visit http://xtal.ipph.purdue.edu/DHD2/



Research Articles

Microparticle Formulations

Park, K.: Nanotechnology: What it can do for drug delivery, J. Control. Release, 120: 1-3, 2007.

Acharya, G., Shin, C.S., McDermott, M., Mishra, H., Park, H., Kwon, I.C., and Park, K.: The hydrogel template method for fabrication of homogeneous nano/microparticles, J. Control. Release, 141: 314-319, 2010.

Acharya, G., Shin, C.S., Vedantham, K., McDermott, M., Rish, T., Hansen, K., Fu, Y. and Park, K.: A Study of Drug Release from Homogeneous PLGA microstructures, J. Control. Release,146: 201-206, 2010.

Kim, K., Kim, J.H., Park, H., Kim, Y.-S., Park, K.S., Nam, H., Lee, S., Park, J.H., Park, R.-W., Kim, I.-S., Choi, K., Kim, S.Y., Park, K. and Kwon, I.C.: Tumor-homing multifunctional nanoparticles for cancer theragnosis: Simultaneous diagnosis, drug delivery, and therapeutic monitoring, J. Control. Release, 146: 219-227, 2010.

Ye, M., Kim, S.W., and Park, K.: Issues in long-term protein delivery using biodegradable microparticles, J. Control. Release, 156: 241-260, 2010.

Kim, D.Y., Kwon, D.Y., Lee, B.N., Seo H.W., Kwon, J.S., Lee, B., Han, D.K., Kim, J.H., Min, B.H., Park, K., and Kim, M.S.: Injectable in situ-forming hydrogels for a suppression of drug burst from drug-loaded microcapsules, Soft Matter, 8: 7638-7648, 2012.

Lu, Y. and Park, K.: Microparticles produced by the hydrogel template method for sustained drug delivery, Int. J. Pharm, 461: 258-269, 2014.

Garner, J., Skidmore, S., Park, H., Park, K., Choi, S., and Wang, Y.: A protocol for assay of poly(lactide-co-glycolide) in clinical products, Int. J. Pharm. 495: 87-92, 2015.

Wang, H., Zhang, G., Sui, H., Liu, Y., Park, K. and Wang, W.: Comparative studies on the properties of glycyrrhetinic acid-loaded PLGA microparticles prepared by emulsion and template methods, Int. J. Pharm., 496: 723-731, 2015.

He, Y. and Park, K.: Effects of the microparticle shape on cellular uptake, Mol. Pharm.,13: 2164-2171, 2016.

Báez-Santos, Y.M., Otte, A., and Park, K.: A fast and sensitive method for the detection of leuprolide ace-tate: a high-throughput approach for the in vitro evaluation of liquid crystal formulations, Anal. Chem. 88: 4613-4618, 2016.

Lee, B.K., Yun, Y., and Park, K.: PLA micro- and nano-particles, in PLA Biodegradable Polymers, Domb, A.J., Langer, R., and Basu, A., Eds., Advanced Drug Delivery Reviews, in press.


Targeted Drug Delivery

Bae, Y.H. and Park, K.: Targeted Drug Delivery to Tumors: Myths, Reality, and Possibility, J. Control. Release, 153: 198-205, 2011.

Kwon, I.K., Lee, S.C., Han, B., and Park, K.: Analysis on the current status of targeted drug delivery to tumors, J. Control. Release, 164: 108-114, 2012.

Park, K.: Facing the truth about nanotechnology in drug delivery, ACS Nano, 7: 7442-7447, 2013.

Yun, Y.H., Lee, B.K., and Park, K.: Controlled Drug Delivery Systems: The Next 30 Years, Frontiers of Chemical Science and Engineering, 8(3): 276-279, 2014.

Park, K.: The controlled drug delivery systems: Past forward and future back, J. Control. Release, 190: 3-8, 2014.

Lee, B.K., Yun, Y.H., and Park, K.: Smart Nanoparticles for Drug Delivery: Boundaries and Opportunities, Chemical Engineering Science, 125: 158-164, 2015.

Yun, Y.H., Lee. B.K., and Park, K.: Controlled Drug Delivery: Historical perspective for the next generation, J. Control. Release, 219: 2-7, 2015.

Park, K.: Drug Delivery of the Future: Chasing the Invisible Gorilla, J. Control. Release, 240: 2-8, 2016.

Park, K.: Drug delivery research: The invention cycle, Mol. Pharm., 13: 2143-2147, 2016.


Shin, C.S., Kwak, B., Han, B., and Park, K.: Development of an in vitro 3D tumor model to study therapeutic efficiency of an anti-cancer drug, Mol. Pharm.,10: 2167-2175, 2013.

Kwak, G., Ozcelikkale, A., Shin, C.S., Park, K., and Han, B.: Simulation of complex transport of nanoparticles around a tumor using yumor-microenvironment-on-chip, J. Control. Release, 194: 157-167, 2014.

Park, K., Han, B., and Korc, M.: Targeting the tumor microenvironment, in Cancer Nanotechnology Plan 2015, Office of Cancer Nanotechnology Research Center for Strategic Scientific Initiatives (CSSI), National Cancer Institute/ NIH. 2015, Section I: Emerging Strategies in Cancer Nanotechnology. pp. 25-26.

Lee, S.J., Koo, H., Lee, D.E., Min, S., Lee, S., Chen, X., Choi, Y., Leary, J.F., Park, K., Jeong, S.Y., Kwon, I.C., and Choi, K.: Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system, Biomaterials, 32: 4021-4029, 2011.

Choi, K.Y., Saravanakumar, G., Park, J.H., and Park, K.: Hyaluronic acid-based nanocarriers for intracellular targeting: interfacial interactions with proteins in cancer, Colloids and Surfaces B: Biointerfaces, 99: 82-94, 2012.

Key, J., Cooper, C., Kim, A.Y., Dhawan, D., Knapp, D.W., Kim, K.M., Park, J.H., Choi, K.W., Kwon, I.C., Park, K., and Leary, J.F.: In vivo NIRF and MR dual-modality imaging using glycolchitosan nanoparticles, J. Control. Release, 163: 249-255, 2012.

Yoon, H.Y., Koo, H., Choi, K.Y., Lee, S.J., Kim, K., Kwon, I.C., Leary, J.F., Park, K., Yuk, S.H. Park, J.H. and Choi, K.: Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy, Biomaterials, 33: 3980-3989, 2012.

Yoon, H.Y., Saravanakumar, G., Heo, R., Choi, S.H., Song, I.C., Han, M.H., Kim, K., Park, J.H., Choi, K., Kwon. I.C. and Park, K.: Hydrotropic magnetic micelles for combined magnetic resonance imaging and cancer therapy, J. Control. Release, 160: 692-698, 2012.

Lee, S.Y., Kim, S.W., Tyler, J., Park, K., and Cheng J.-X.: Blood-stable, tumor-adaptable disulfide bonded MPEG-(Cys)4-PDLLA micelles for chemotherapy, Biomaterials, 34: 552-561, 2013.

Lee, S.Y., Tyler, J., Kim, S.W, Park, K., and Cheng, J.X.: FRET imaging reveals different cellular entry routes of self-assembled and disulfide bonded polymeric micelles, Mol. Pharm., 10: 3497-3506, 2013.

Koo, H., Min, K.H., Lee, S.C., Park, J.H., Park, K., Jeong, S.Y., Choi, K., Kwon, I.C., and Kim, K.M.: Enhanced drug-loading and therapeutic efficacy of hydrotropic oligomer-conjugated glycol chitosan nanoparticles for tumor-targeted paclitaxel delivery, J. Control. Release, 72: 823-831, 2013.

Lu, Y., Wang, Z.-H., Ki, T., McNally, H., Park, K., and Sturek, M.: Development and evaluation of transferrin-stabilized paclitaxel nanocrystal formulation, J. Control. Release, 176: 76-85, 2014.

Lee, S.S., Li, J., Tai, J.N., Ratliff, T.L., Park, K., and Cheng J.-X.: Avasimibe encapsulated in human serum albumin blocks cholesterol esterification for selective cancer treatment, ACS Nano, 9(3): 2420-2432, 2015.

Xu, C., Wang, P., Zhang, J., Tian, H., Park, K., and Chen, X.: Pulmonary codelivery of doxorubicin and siRNA by pH-sensitive nanoparticles for therapy of metastatic lung cancer, Small, 11 (34): 4321-4333, 2015.

Chen, J., Lin, L., Guo, Z., Xu, C., Tian, H., Park, K., and Chen, X.: Synergistic treatment of cancer stem cells by combinations of antioncogenes and doxorubicin, J. Drug Del. Sci. Tech., 30: 417-423, 2015.

Ma, Y., He, S., Ma, X., Hong, T., Li, Z., Park, K., and Wang, W.: Silymarin-loaded nanoparticles based on stearic acid-modified Bletilla striata polysaccharide for hepatic targeting, Molecules, 21: 265 (10 pages), 2016.

Kim, D.Y., Kwon, D.Y., Kwon, J.S., Park, J.H., Park, S.H., Oh, H.J., Kim, J.H., Min, B.H., Park, K., and Kim, M.S.: Synergistic anti-tumor activity through combinational intratumoral injection of an in-situ injectable drug depot, Biomaterials 85: 232-245, 2016.

Key, J., Dhawan, D., Cooper, C.L., Knapp, D.W., Kim, K., Kwon, I.C., Choi, K., Park, K., Decuzzi, P., Leary, J.F.: Multicomponent, peptide-targeted glycol chitosan nanoparticles containing ferrimagnetic iron oxide nanocubes for bladder cancer multimodal imaging, Int. J. Nanomedicine, 11; 4141-4155, 2016.


Hydrotropic Polymer Micelles

Saravanakumar, G., Min, H.H., Min, D.S., Kim, A.Y., Lee, C.M., Cho, Y.W., Lee, S.C., Kim, K., Jeong, S.Y., Park, K., Park, J., and Kwon, I.C.: Hydrotropic oligomer-conjugated glycol chitosan as a carrier of paxclitaxel: Synthesis, characterization, and in vivo biodistribution, J. Control. Release, 140: 210-217, 2009.

Saravanakumar, G., Choi, K.Y., Yoon, H.Y., Kim, K., Park, J.H., Kwon, I.C., Park, K.: Hydrotropic hyaluronic acid conjugates: Synthesis, characterization, and implications as a carrier of paclitaxel. Int. J. Pharm., 394: 154-161, 2010.

Kim, J.Y., Kim, S.W., Papp, M., Park, K., and Pinal, R.: Hydrotropic solubilization of poorly water-soluble drugs, J. Pharm. Sci. 99: 3953-3965, 2010.

Chen, H., Kim, S., Li, L., Wang, S., Park, K., Cheng, J-X.: Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Förster resonance energy transfer imaging, Proc. Natl. Acad. Sci. USA, 105 (18): 6596-6601, 2008.

Chen, H., Kim, S., He, W., Wang, H., Low, P.S., Park, K., and Cheng, J-X.: Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo förster resonance energy transfer imaging, Langmuir, 24: 5213-5217, 2008.

Shi, Y., Kim, S.W., Huff, T.B., Borgens, R.B., Park, K., Shi, R., and Cheng, J.-X.: Effective repair of traumatically injured spinal cord by nanoscale block copolymer micelles, Nature Nanotech, 5: 80-87, 2010.

Kim, J.Y., Kim, S.W., Pinal, R., and Park, K.: Hydrotropic polymer micelles as versatile vehicles for delivery of poorly water-soluble drugs, J. Control. Release, 152: 13-20, 2011.

Lu, Y. and Park, K.: Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs, Int. J. Pharm., 453: 198-214, 2013.



Oral Drug Delivery

Jeong, S.H., Takaishi, Y., Fu, Y., and Park, K.: Materials for making fast dissolving tablets by compression method, J. Mater. Chem. 18: 3527-3535, 2008.

Jeong, S.H. and Park, K.: Development of sustained release fast-disintegrating tablets using various polymer-coated ion-exchange resin complexes, Int. J. Pharm., 353: 195-204, 2008.

Jeong, S.H. and Park, K.: Drug loading and release properties of ion-exchange resin complexes as a drug delivery matrix, Int. J. Pharm., 361: 26-32, 2008.

Wen, H., Morris, K., and Park, K.: Synergic effects of polymeric additives on dissolution and crystallization of acetaminophen, Pharm. Res., 25: 349-358, 2008.

Park, Kyeongsoon, and Park, Kinam: Oral protein delivery: Current status and future prospect, Reactive and Functional Polymers, 71: 280-287, 2011.

Yun, Y. and Park, K.: Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery, Adv. Drug Del. Rev., 65: 822-832, 2013.

Choi, D.H., Kim K.H., Park, J.S., Jeong, S.H., and Park, K.: Evaluation of drug delivery profiles in geometric three-layered tablets with various mechanical properties, in vitro–in vivo drug release, and Raman imaging, J. Control. Release, 172: 763-772, 2013


Smart Polymers & Hydrogels

Chaterji, S., Kwon, I.K., and Park, K.: Smart polymeric gels: Redefining the limits of biomedical devices, Prog. Polym. Sci., 32: 1083-1122, 2007.

Qiu, Y. and Park, K.: Environment-sensitive hydrogels for drug delivery, Advanced Drug Delivery Reviews, 53: 321-339, 2001. 64: 49-60, 2012.

Omidian. H. and Park, K.: Hdrogels, in Fundamentals and Applications of Controlled Release Drug Delivery, Juergen Siepmann, Ronald Siegel, and Michael Rathbone, Eds. Spinger, New York, NY, 2012, pp. 75-106.

Mastropietro, D., Omidian, H., and Park, K.: Drug delivery applications for superporous hydrogels, Expert Opinion on Drug Delivery,9: 71-89, 2012.

Lee, S.C., Kwon, I.K. and Park, K.: Hydrogels for delivery of bioactive agents: a historical perspective, Adv. Drug Del. Rev., 65: 17-20, 2013.

Han, B., Yun, G.Y., Boley, W., Kim, H.D., Hwang, J.Y., Chiu G., and Park, K.: Dropwise gelation-dehydration kinetics during drop-on-demand printing of hydrogel-based materials, Int. J. Heat Mass Transfer, 30: 417-423, 2016.


Drug-eluting Stents & Balloons

Finkelstein, A., Mcclean, D., Kar, S., Takizawa, K., Vargeese, K., Baek, N., Park, K., Fishbein, M.C., Makkar, R., Litvack, F., and Eigler, N.L. Local drug delivery via a coronary stent with programmable release pharmacokinetics. Circulation 107: 777-784 2003.

Kang, E., Wang, H., Kwon, I.K., Robinson, J., Park, K. and Cheng, J-X.: In situ visualization of paclitaxel distribution and release by coherent anti-Stokes Raman scattering microscopy, Anal. Chem., 78: 8036-8043, 2006.

Kang, E., Robinson, J., Park, K., and Cheng, J-X.: Paclitaxel distribution in poly(ethylene glycol) / poly(lactide-coglycolic acid) blends and its release visualized by coherent anti-Stokes Raman scattering microscopy, J. Control. Release, 122: 261-268, 2007.

Kang, E., Wang, H., Kwon, I.K., Song, Y-H., Kamath, K., Miller, K.M., Barry, J., Cheng, J-X., and Park, K.: Application of coherent anti-Stokes Raman scattering microscopy to image the changes in a paclitaxel-poly(styrene-b-isobutylene-b-styrene) matrix pre and post drug elution, J. Biomed. Mater. Res. A, 87: 913-920, 2008.

Kang, E., Vedantham, K., Long, X., Dadarlat, M., Kwon, I.K., Sturek, M., and Park, K.: A drug-eluting stent for delivery of signal pathway-specific 1,3-dipropyl-8-cyclopentyl xanthine (DPCPX), Molecular Pharmaceutics, 6(4): 1110-1117, 2009.

Paderi, J., Sturat, K., Sturek, M., Park, K., and Panitch, A.: The inhibition of platelet adhesion and activation on collagen during balloon angioplasty by collagen-binding peptidoglycans, Biomaterials, 32: 2516-2523, 2011.

Muto, A., Panitch, A., Kim, N.H., Park, K., Komalavilas, P., Brophy, C.M., and Dardik, A.: Inhibition of mitogen activated protein kinase activated protein Kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo, Vascular Pharmacology, 56: 47-55, 2012.

Vedantham, K., Chaterji, S., Kim, S.W., and Park, K.: Development of a probucol-releasing anti-thrombogenic drug eluting stent, J. Biomed. Mater. Res. Part B: Appl. Biomater.100B: 1068-1099, 2012.

Scott, R.A., Park, K., Panitch, A.: Water soluble polymer films for intravascular drug delivery of antithrombotic biomolecules, Eur. J. Pharm. Biopharm., 84: 125-131, 2013.

JCR Cover Stories

Kinam Park: Exosome-based therapeutic approach for muscle regeneration, J. Control. Release 222 (2016) 176.
Kinam Park: Targeting prostate cancer cells en route to dissemination, J. Control. Release 223 (2016) 224.
Kinam Park: A hydrophilic matrix approach for controlled vaginal drug delivery, J. Control. Release 224 (2016) 240.
Kinam Park: Dissolving microneedle vaccine delivery system, J. Control. Release 225 (2016) 314.
Kinam Park: Isolated lung model for assessing drug absorption from PLGA microparticle, J. Control. Release 226 (2016) 268.
Kinam Park: Magnetic resonance imaging for developing intramuscular formulations, J. Control. Release 227 (2016) 94.
Kinam Park: Enhanced antitumor effects of hTRAIL by binding to endogenous albumin, J. Control. Release 228 (2016) 206.
Kinam Park: Visualization of focal permeation sites within epithelial barriers, J. Control. Release 229 (2016) 200.
Kinam Park: Sustained delivery of antibodies in vivo by local retention, J. Control. Release 230 (2016) 116.
Kinam Park: Enhanced antitumor effects of hTRAIL by binding to endogenous albumin, J. Control. Release 232 (2016) 265.
Kinam Park: Organotypic non-melanoma skin cancer models for use in preclinical research, J. Control. Release 233 (2016) 220.
Kinam Park: Pulmonary delivery of anti-ricin antibody: From the bench to the clinic, J. Control. Release 234 (2016) 135.
Kinam Park: Sustained efficacy of paclitaxel nanocrystals in hydrogel depot, J. Control. Release 235 (2016) 393.
Kinam Park: Acoustic Cluster Therapy for better treatment of solid tumors, J. Control. Release 236 (2016) 117.
Kinam Park: Mechanisms controlling drug release from coated pellets, J. Control. Release 237 (2016) 185.
Kinam Park: Maintaining protein activity during hydrogel cross-linking, J. Control. Release 238 (2016) 313.
Kinam Park: Hemocompatible and immune-safe library of citrem-phospholipid liquid crystalline nanoplatforms, J. Control. Release 239 (2016) 249.
Kinam Park: In vivo DNA delivery with NickFect peptide vectors, J. Control. Release 241 (2016) 242.