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New Course: ABE 202. Thermodynamics in Biological Systems IIEngineering Faculty Document No.29-03 January, 2004 TO: Engineering Faculty FROM: The Faculty of Agricultural and Biological Engineering RE: New Undergraduate Course The faculty of the Department of Agricultural and Biological Engineering has approved the following new course. This action is now submitted to the Engineering Faculty with a recommendation for approval. ABE 202 - Thermodynamics in Biological Systems II Sem. 2, Class 3, cr. 3. Prerequisites: ABE 201, MATH
261 Thermodynamic principles and their
applications to biochemical and biological systems with emphasis on the second
law of thermodynamics and use of molecular interpretations of energies and
entropies. Concept of entropy balances and process efficiency. Free energy and chemical equilibrium. Equilibrium between phases, colligative
properties, binding of ligands and formation of biological membranes. Molecular motion and transport properties and
their application in biochemical analytical methods. Development of physical chemical problem
solving skills using MathCad and Matlab software. Reasons: A background in thermodynamic principles is essential to understanding
biological and biochemical processes.
This course is the second in a consecutive two course series in biological
thermodynamics. _____________________________________ Vince F. Bralts Head, Department of Agricultural and Biological Engineering ABE
202: Thermodynamics in Biological Systems II Sem. 2, Class 3, cr. 3. Prerequisites ABE 201 &
MATH 261 Textbook Physical
Chemistry. Principles and Applications
in Biological Sciences. Tinoco, Course
Handouts Description Thermodynamic principles and their applications to
biochemical and biological systems with emphasis on the second law of
thermodynamics and use of molecular interpretations of energies and entropies. Concept
of entropy balances and process efficiency.
Free energy and chemical equilibrium.
Equilibrium between phases, colligative properties, binding of ligands
and formation of biological membranes. Molecular
motion and transport properties and their application in biochemical analytical
methods. Development of physical chemical problem
solving skills using MathCad and Matlab software. Course Learning Objectives: 1.
Application of
basic thermodynamic concepts and relationships between thermodynamic properties
to study biological systems 2.
Apply phase
and chemical equilibrium concepts to understand physical chemical phenomena in
biological systems 3.
Develop an
understanding of models for ideal and non-ideal physical behavior of biological
materials at equilibrium in multicomponent multiphase systems 4.
Develop and
apply predictive equations on the calculation of colligative properties of food
and biological systems 5.
Understand the
role of transport phenomena in foods and biological systems Course
Outline Week 1-2 Introduction, Review of the
First Law of Thermodynamics and Application of Balance of Mass and Energy to
Food and Biological Systems. Second Law of
Thermodynamics. Definition of Entropy,
concept of reversibility 3-4 Application
of entropy balances to estimate the efficiency of food and biological processes
and in cycles and pathways. Application of the Second Law to biological
reactions, hydrophobic interactions and interactions between biological systems
(e.g. proteins and acid nucleics) 5-7 Maxwell relationships, thermodynamic relationships. Free energy and
chemical equilibria. Chemical reaction equilibrium. Effect
of temperature on equilibrium constant. Biochemical
applications of thermodynamics.
Thermodynamics of metabolism.
Electron transfer and biological redox reactions. Ligand binding 8-10
Free energy and physical equilibria. Transport
phenomena in biological systems, concept of chemical gradients. Biological Membranes and Transport. Colligative properties, Boiling Point
elevation, Freezing point depression, osmotic pressure, Donnan Effect. Concept
on equations of state. 11-12
Fugacity concept.
Fugacity calculations. Introduction to multicomponent systems. Partial molar properties, chemical potential
and activity concepts. Ideal solutions. Vapor-liquid equilibrium. Dew point calculations. 13-14 Kinetics: Rates of Chemical Reactions. Diffusion-controlled
reations, Phothochemistry and Photobiology.
Ionic Reactions and Salt Effects, Dissociation constants, Debye-Huckel
Theory, Salting in and Salting out effects
on proteins. 15 Concepts on Molecular Motion and Transport Properties.
Difussion, Sedimentation, Electrophoresis, Viscosity. Applications to determine molecular properties
of biological molecules. |
