![Recent Research](Figures/researchpic.jpg)
Research
A variety of research endeavors are currently underway in the BBML. Our work focuses predominantly on bone, muscle and tendon. Click below to learn more about the general areas of research.
Welcome to the BBML in the Weldon School of Biomedical Engineering at Purdue University. The BBML is committed to improving our understanding of how the body works through innovative preclinical and clinical research. As our name implies, the lab focuses on bone mechanics (ability to effectively bear loads) and mechanobiology (how cells respond to mechanical stimuli to maintain and/or increase bone mass). We investigate bone from mechanical engineering and materials science perspectives by tying morphology and composition to mechanical function and fracture resistance at discrete length scales throughout bone's hierarchy.
Our long-term goal is to use combinatorial treatments for a number of relevant diseases that have musculoskeletal complications which lead to bone fragility and fracture. Our current focus is on mechanical and pharmaceutical manipulations of bone quality and quantity to intervene and increase bone fracture resistance even in the face of inferior tissue quality. A common thread that passes through all of our research is an intense focus on collagen and the role it plays in bone health. Our research is currently funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Science Foundation (NSF), and the US Department of Veteran Affairs (VA). Full funding details can be found here and information about these grants is also available in the research tab.
In these first few weeks of 2025, Rachel Kohler and Olivia Reul have each had a paper published in Bone and Journal of the Mechanical Behavior of Biological Materials, respectively!
Welcome 2025! It will be hard to have a better year than 2024, but we will try! In addition to our transition to Purdue University, last year saw the continuation or funding of 8 federal grants (3 as PI), the normal turnover of personnel, and the publication of 12 peer-reviewed papers. Thanks to everyone in the lab who made it all possible! 2025 will start fast, with 3 presentations at the 2025 Annual Meeting of the Orthopaedic Research Society in Phoenix this February. Congrats to Olivia (PhD student), Amanda (MS student), and Katelynn (undergraduate student)!
The BBML is actively looking for highly motivated graduate students and postdoctoral candidates with a solid background in musculoskeletal biomechanics to take the lead on one of several funded projects from the NSF, VA, or NIH. Ideally, the candiates will have experience with in vivo experiments and working as a mentor of students in a research setting. Please click here for information on how to become a part of our team.
In November 2024, Amanda Wagner successfully defended her MS thesis, completed in only 1.5 years. Congrats Amanda!
On October 7, 2024, we are happy to welcome our newest lab member. Maria Prado has joined us as a postdoc after having completed her Ph.D. in Biomedical Engineering from the University of Texas at San Antonio.
On July 1, 2024, the transition from IUPUI to Purdue University will be complete. Dr. Wallace will be a Professor in the Weldon School of Biomedical Engineering, and Associate Vice President for Research Development for Indianapolis. We are all excited for the opportunities this transition brings to the lab and for the campus as a whole!
A variety of research endeavors are currently underway in the BBML. Our work focuses predominantly on bone, muscle and tendon. Click below to learn more about the general areas of research.
Click below to learn more about the people in our lab who make all of this exciting work possible.
Our lab actively publishes in journals spanning the areas of bone and mineral and general biomechanics. To view of list of our publications, click the link below.