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Sensor Design for Pharmaceutical and Biomedical Applications

Project Description

The project aims to develop an integrated device for continuous monitoring in pharmaceutical or biomedical applications by combining microfluidics with Raman and Fourier Transform Infrared (FTIR) spectroscopy. The project seeks to overcome the limitations of existing monitoring techniques by providing real-time, non-destructive measurements with enhanced sensitivity. Through deep learning algorithms, the project aims to establish correlations between observed spectra and analyte properties, facilitating accurate quantification. Our multidisciplinary team combines expertise in spectroscopy, deep learning, microfluidics, and sensor integration. 

Start Date

February 2025

Postdoc Qualifications

The postdoctoral researcher should have a degree in Material Engineering, Mechanical Engineering, Computer Engineering, Applied Mathematics, Biomedical Engineering, or equivalent. The research requires a strong background in microfluidics, spectroscopy, wearables, or machine learning and artificial intelligence. 

Co-advisors

Arezoo Ardekani, Professor of Mechanical Engineering, ardekani@purdue.edu
https://web.ics.purdue.edu/~ardekani/

Rahim Rahimi, Assistant Professor of Material Engineering, rrahimi@purdue.edu
https://www.rahimilab.org/?_ga=2.178571367.210477310.1720535032-135177814.1628068362

Bibliography

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[2] E. E. Jacobson, D. F. Fletcher, M. K. Morgan, and I. H. Johnston. Computer modelling of the cerebrospinal fluid flow dynamics of aqueduct stenosis. Medical & biological engineering & computing, 37(1): 59–63, 1999.
[3] M. Khani, L. R. Sass, T. Xing, M. Keith Sharp, O. Bal´edent, and B. A. Martin. Anthropomorphic model of intrathecal cerebrospinal fluid dynamics within the spinal subarachnoid space: spinal cord nerve roots increase steady-streaming. Journal of Biomechanical Engineering, 140(8), 2018.
[4] S. Yamada, H Ito, M. Ishikawa, et al., Quantification of Oscillatory Shear Stress from Reciprocating CSF Motion on 4D Flow Imaging. AJNR Am J Neuroradiol. 2021 Mar;42(3):479-486.
[5] M. Matsumae, A. Hirayama, H. Atsumi et al., Velocity and pressure gradients of cerebrospinal fluid assessed with magnetic resonance imaging. J Neurosurg. 2014 Jan;120(1):218-27.