Nanostructured Surface-Functionalized Materials for Artificial Basement Membranes

Interdisciplinary Areas: Engineering-Medicine

Project Description

Hydrogels and other soft materials are often used as artificial extracellular matrix (ECM) to promote tissue regeneration following injury. However, hydrogels often lack important nano- and microstructured chemical and mechanical cues that are critical to the function of real ECM. Our laboratories are working together to develop artificial ECM that uses unique surface functionalization strategies to embed precisely controlled chemistries that promote desired cellular adhesion, proliferation, and differentiation processes. We know that this strategy is effective in controlling myoblast (muscle) cell adhesion and growth and are exploring impacts on other cell lines. We anticipate that the postdoctoral position will involve work in both nanoscale interface functionalization/characterization and cell culture. Our ultimate goal is to design ultrathin interfacial layers that recapitulate functions of biological basement membranes important in controlling epithelial and endothelial layer growth, driving differentiation, and for interrogating environmental factors that can lead to improved regulation of tissue function. 


Start Date

Fall 2023


Postdoc Qualifcations

*Highly motivated and independent researcher
*Excellent written and oral communication skills
*Strong publication record
*Eager to join interdisciplinary team that touches on topics in biomedical engineering, chemistry, tissue engineering, and materials science



Luis Solorio,, Weldon School of Biomedical Engineering,

Shelley Claridge,, Department of Chemistry and Weldon School of Biomedical Engineering,


Short Bibliography

1. " Control of C2C12 Murine Myoblast Adhesion and Differentiation by Hierarchically Patterned Elastomeric Surfaces" Willams, L.O.; Libring, S.M.; Davis, T.C.; Miller, A.F.; Calve, S.; Solorio, L.; Claridge, S.A. In preparation.

2. Method for directing cell adhesion and growth using ultrathin striped molecular films on top of polyacrylamide hydrogels. Claridge, S.A.; Arango, J.C.; Solorio, L.; Libring, S. Utility patent application filed 5 May 2023.

3. “Surface-Templated Glycopolymer Nanopatterns Transferred to Hydrogels for Designed Multivalent Carbohydrate–Lectin Interactions across Length Scales.” Singh, A.; Arango, J.C.; Shi, A.; d’Aliberti, J.B.; Claridge, S.A. Journal of the American Chemical Society, 2023, 145, 1668–1677.

4. “Plenty of Room at the Top: A Multi-Scale Understanding of nm-Resolution Polymer Patterning on 2D Materials.” Shi, A.; Villarreal, T.A.; Brooks, J.T.; Hayes, T.R.; Claridge, S.A. Angewandte Chemie, 2021, 60, 25436-25444.

5. “High-throughput Magnetic Actuation Platform for Evaluating the Effect of Mechanical Force on 3D Tumor Microenvironment” Enriquez A.; Libring S; Field T.C.; Jimenez J.; Lee T.; Park H.; Satoski D.; Wendt M.K.; Calve S.; Buganza Tepole A.; Solorio L.; Lee H. Advanced Functional Materials, 2021, 31(1)