Mechanical Engineering


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Journal Articles


51. Challenges and Progress in Modeling Multiscale Soft Tissue Mechanobiology
Guo Y, Mofrad MRK,Tepole AB. 2022. In revision.


50. PDE-constrained shape registration to characterize biological growth and morphogenesis from imaging data
Pawar A, Li L, Gosain AK, Umulis D, Tepole AB. 2022. Submitted


49. Anisotropic damage model for collagenous tissues and its application to model fracture and needle insertion mechanics
Toaquiza Tubon J, Moreno Flores O, Tepole AB. 2022. Submitted


48. MOSAIC: Modular Soft Assemblies with Independent Cells
Hutchins BL, Mansour O, Chen JR, Tepole AB. 2022. Submitted


47. Automatically Polyconvex Strain Energy Functions using Neural Ordinary Differential Equations
Tac V, Sahli Costabal F, Tepole AB. 2022. Submitted (available at Arxiv).


46. Multiscale mechanobiology: coupling models of adhesion kinetics and nonlinear tissue mechanics
Guo Y, Calve S, Tepole AB. 2021. In press at Biophysical Journal.


45. Data-driven Modeling of the Mechanical Behavior of Anisotropic Soft Biological Tissue
Tac V, Sree VD, Rausch MK, Tepole AB. 2021. Submitted. (available at arXiv)


44. The Biomechanics of Autoinjector - Skin Interactions During Dynamic Needle Insertion
Sree VD, Ardekani A, Vlachos P, Tepole AB. 2022. Accepted at Journal of Biomechanics.


43. The biaxial mechanics of thermally denaturing skin - Part I: Experiments
Meador W, Sugrman E, Tepole AB, Rausch MK. 2021. Acta Biomaterialia. (available at BiorXiv)


42. The biaxial mechanics of thermally denaturing skin - Part II: Modeling
Rausch MK, Toaquiza Tubon J, Moreno Flores O, Tepole AB. 2021. Acta Biomaterialia. (available at BiorXiv)


41. Bayesian Calibration of a Computational Model of Tissue Expansion Based on a Porcine Animal Model
Han T*, Lee T*, Ledwon J, Vaca E, Turin SY, Kearney A, Gosain AK, Tepole AB. 2021. Acta Biomaterialia.


39. Predicting the Mechanical Properties of Fibrin Using Neural Networks Trained on Discrete Fiber Network Data
Leng Y, Calve S, Tepole AB. 2021. Computer Methods in Applied Mechanics and Engineering.


38. High‐Throughput Magnetic Actuation Platform for Evaluating the Effect of Mechanical Force on 3D Tumor Microenvironment
Enríquez Á, Libring S, Field TC, Jimenez J, Lee T, Park H, Satoski D, Wendt MK, Calve S, Tepole AB, Solorio L, Lee H. Advanced Functional Materials. 2021 Jan;31(1):2005021.


37. Acceleration of PDE-based biological simulation through the development of neural network metamodels
Burzawa L, Li L, Wang X, Tepole AB, Umulis DM. Current Pathobiology Reports (2020): 1-11.


36. The geometry of incompatibility in growing soft tissues: Theory and numerical characterization
Lee T, Holland M, Weickenmeier J, Tepole AB. J Mech Phys Solids. 2021:146, 104177


35. Improving reconstructive surgery design using Gaussian process surrogates to capture material behavior uncertainty
Stowers C, Lee T, Gosain AK, Bilionis I, Tepole AB. J Mech Behav Biomed Mat, 2021: 118, 104340.


33. Personalized computational models of tissue-rearrangement in the scalp predict the mechanical stress signature of rotation flaps
Lee T *, Turin S*, Stowers C, Gosain AK, Tepole AB. The Cleft Palate - Craniofacial Journal. 2021: 58 (4), 438-445


32. Modeling tissue expansion with isogeometric analysis: Skin growth and tissue level changes in the porcine model
Janes LE, Ledwon JK, Vaca EE, Turin SY, Lee T, Tepole AB, Bae H, Gosain MK. Plast Reconstr Surg. 2020: 146 (4), 792-798.


31. Multiscale modeling meets machine learning: What can we learn?
Peng G, Alber M, Tepole AB, Cannon W, De S, Dura-Bernal S, Garikipati K, Karniadakis G, Lytton WW, Perdikaris P, Petzold L, Kuhl E. Arch Comput Method Eng. 2020


29. Integrating machine learning and multiscale modeling: Perspectives, challenges, and opportunities in the biological, biomedical, and behavioral sciences
Alber M, Tepole AB, Cannon W, De S, Dura-Bernal S, Garikipati K, Karniadakis G, Lytton WW, Perdikaris P, Petzold L, Kuhl E. nPj Digital Medicine. 2019; 2(1):1-11.


28. Probabilistic vortex crossing criterion for superconducting nanowire single-photon detectors
Jahani S, Yang LP, Tepole AB, Bardin JC, Tang HX and Jacob Z. J Appl Phys. 2020; 127(14): 143101.


26. Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing
Glieberman AL, Pope BD, Zimmerman JF, Liu Q, Ferrier Jr JP, Kenty JH, Schrell AM, Mukhitov N, Shores KL, Tepole AB, Melton DA, Roper MG, Parker KK. Lab Chip. 2019; 19:2993-3010.


20. Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model
Chantre CO, Campbell PH, Golecki HM, Buganza Tepole A, Capulli AK, Deravi LF, Dauth S, Sheehy SP, Paten JA, Gledhill K, Doucet YS, Abaci HE, Ahn S, Pope BD, Ruberti JW, Hoerstrup SP, Christiano AM, Parker KK. Biomat. 2018;166:96-108.


19. Improving tissue expansion protocols through computational modeling
Lee T, Vaca EE, Ledwon JK, Bae H, Topczewska JM, Turin SY, Kuhl E, Gosain AK, Buganza Tepole A.
J Mech Behav Biomed Mat. 2018;82:224-34.


18. Digital analysis yields more reliable and accurate measures of dermal and epidermal thickness in histologically processed specimens compared to traditional methods
Turin SY, Ledwon JK, Bae H, Buganza Tepole A, Topczewska J, and Gosain AK. Experiment Dermatol. 2018; 27:687-690.


17. Determining the differential effects of stretch and growth in tissue expanded skin
Purnell C, Gart M, Buganza Tepole A, Tomaszewski J, Topczewska J, Kuhl E and Gosain AK. Dermatol Surg. 2018; 44(1):48-52.


16. Computational systems mechanobiology of wound healing
Buganza Tepole A. Comput Method Appl Mech Eng. 2017; 314: 46-70.
Code associated with this publication


15. Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics
Buganza Tepole A, Purnell C, Gart M, McGrath J, Kuhl E and Gosain AK. Journal of Visual Experiments. 2017; 122: e55052.
Code associated with this publication


14. Skin stretching by a balloon tissue expander: Inter- play between contact mechanics and skin growth
Srivastava A, Buganza Tepole A, Hui CY. Extreme Mech Lett. 2016; 9: 175-187.


13. A Finite Element Model for Mixed Prohyperelasticity with Transport, Swelling, and Growth
Hine MA, Buganza Tepole A, Kuhl E, Simon BR, Vande Geest JP. Plos ONE. 2016, dx.doi.org/10.1371/journal.pone.0152806


12. The incompatibility of living systems: Characterizing growth-induced incompatibilities in expanded skin
Buganza Tepole A, Gart M, Purnell CA, Gosain AK, Kuhl E. Ann Biomed Eng. 2016; 44: 1734-1752.


11. Isogeometric Kirchhoff-Love shell formulations for biological membranes
Buganza Tepole A, Kabaria H, Bletzinger KU, Kuhl E. Comp Meth Appl Mech Eng. 2015; 293: 328-347.


10. Computational modeling of chemo-bio-mechanical coupling: A systems-biology approach towards wound healing
Buganza Tepole A, Kuhl E. Comp Meth Biomech Biomed Eng. 2016; 19: 13-30.


9. Characterization of living skin using multi-view stereo and isogeometric analysis
Buganza Tepole A, Gart M, Gosain AK, Kuhl E. Acta Biomat. 2014; 10: 4822-4831.


8. Application of finite element modeling to optimize flap design with tissue expansion
Buganza Tepole A, Steinberg JP, Kuhl E, Gosain AK. Plast Reconstr Surgery. 2014; 134: 785-792.


6. Multi-view stereo analysis reveals anisotropy of prestrain, deformation and growth in living skin
Buganza Tepole A, Gart M, Purnell CA, Gosain AK, Kuhl E. Biomech Model Mechanobiol. 2015; 14: 1007-1019


5. Systems-based approaches toward wound healing
Buganza Tepole A and Kuhl E. Pediatric Res. 2013; 73: 553-563.


4. Growing skin: tissue expansion in pediatric forehead reconstruction
Zoellner AM, Buganza Tepole A, Gosain AK and Kuhl E. Biomech Mod Mechanobiol. 2012; 11(6): 855-867.


3. Biomechanics and mechanobiology of growing skin
Zoellner AM, Buganza Tepole A, and Kuhl E. J Theor Biol. 2012; 297: 166-175.


2. Stretching skin: the physiological limit and beyond
Buganza Tepole A, Gosain AK, and Kuhl E. Int J Nonlin Mech. 2012; 47(8): 938-949.


1. Growing skin - A computational model for skin expansion in reconstructive surgery
Buganza Tepole A, Ploch CJ, Wong J, Gosain AK, Kuhl E. J Mech Phys Solids. 2011; 59: 2177-2190.