The Buganza Lab focuses on the application of computational approaches from applied mechanics and systems biology to advance translational medicine by simulating disease, diagnosis, treatment and medical device design on patient-specific scenarios.
Prof. Buganza Tepole is currently an Assistant Professor of Mechanical Engineering and Biomedical Enginering (by courtesy) at Purdue University. Prior to joining Purdue in the Fall of 2016 he was a Postdoctoral Fellow at Harvard University. He graduated with his PhD from Stanford in 2015.
Unlike structural materials, tissues actively adapt to their environment by signaling networks between mechanical cues, cells, and chemicals across several temporal and spatial scales. The fundamental interplay between form and function, from the cell to the tissue level, gives rise to the complex mechanical behavior of living tissue. Modeling, experimentation, and computation can, on the one hand, help us understand the fundamental mechanisms underlying tissue adaptation, while ultimately generating inexpensive technologies to improve healthcare. My research uses the theory of mechanics and computational systems biology to characterize tissue response in relevant medical problems.