DNABBB: DNA Nanomaterials for Drug Delivery through the BBB
This team will work with BME Kinzer-Ursem lab to build and test DNA nanomaterials for miRNA drug delivery across the Blood-Brain Barrier. This research will potentially help mitigate the symptoms of neurodegenerative diseases.
Faculty Advisor:
Mentor:
Description:
The team will work towards the development of DNA tetrahedra (TDN) and applying them in human cells to deliver miRNA and trigger RNA interference. The goal of the team will be to bring this technology as close to an actual product as possible, which includes iterative redesign to meet the needs of potential patients. Some of the specific projects now include testing miRNA release mechanisms; functionalization of DNA TDN with cationic molecules; testing the delivery vehicle in physiologically relevant cells.
Relevant Technologies:
DNA nanotechnology, drug delivery, cellular imaging.
Prerequisites:
No prerequisite skills are required; however, a wet lab experience (PAGE, cell culture) is a bonus. BME, BioE, chemistry, ChemE, and other chemistry or biology majors are preferred. This is a 10-15 h weekly lab work commitment.
Website of project:
https://engineering.purdue.edu/ursemlab/, https://www.gar-nano.com/