MATLAB–Arduino Connection Issues
Error
Error: MATLAB Cannot Connect to the Arduino Serial Port
The example below shows a connection error that occurs when MATLAB cannot communicate with the Arduino board. This typically happens when the serial port is not available, the board was not configured correctly, or another program is using the port.
Figure 1: Error: “Invalid operation. Object must be connected to the serial port.”

To fix this issue, verify the following:
- USB connection is secure, and the board is powered.
- The correct COM port was selected during setup (arduinosetup).
- The MATLAB server was successfully uploaded (look for “success!” in Step 7).
- Close any program using the port (Arduino IDE, Serial Monitor).
- Restart MATLAB if the error continues.