School of Chemical Engineering

Crystallization and Particle T echnology
Systems Engineering

Welcome to CryPTSys!

Supervised by Prof. Zoltan K. Nagy, the core research areas of CryPTSys consist of design and control of batch and continuous crystallization systems and advanced control with process intensification of manufacturing systems engineering for applications in the pharmaceutical, fine chemical, biotechnology, food, agrochemical, and energetic industries. Using modeling, optimization and advanced control approaches, this research is conducted experimentally with modern process analytical technology tools (PAT) as well as computationally using complex mathematical models for model-based approaches.

CryPT-Sys Spring 2024

View More Images

Recent News

  • October 29, 2024 Current and alumni members of the CryPTSys group at AIChE 2024 in San Diego, California!
  • October 29, 2024 Congratulations to Yash Barhate for winning a PD2M Student Award at AIChE!
  • October 29, 2024 Congratulations to Montgomery Laky for winning a Separations Division Graduate Student Award at AIChE!
  • October 7, 2024 Congratulations to Prof. Zoltan Nagy for winning the prestigious "2024 Excellence and Impact Award (Manufacturing)", announced by AIChE's PD2M Forum!
  • September 26, 2024 Congratulations to Montgomery Laky for recognition as a MIT Chemical Engineering Rising Star!
  • September 17, 2024 Congratulations to Megha Das for winning the prestigious centennial award for exceptional performance in her first-year of Graduate School!
  • August 15, 2024 Congratulations to Monika Neal for winning 1st best Overall Poster at the 33rd annual Purdue GSO Symposium!
  • August 15, 2024 Congratulations to Montgomery Laky for winning 1st best Presentations in Biotech & Pharmaceuticals at the 33rd annual Purdue GSO Symposium!
  • August 2, 2024: Inyoung Hur successfully defended her thesis: "Model-based design and control of an integrated purification platform for continuous pharmaceutical manufacturing". She was advised by Prof. Zoltan K. Nagy.
  • July 25, 2024 Aishwarya Menon (left) and Urvi Mathur (right) presented their summer work at SURF!
  • June 20, 2024 "Process Intensification via End-to-End Continuous Manufacturing of Atorvastatin Calcium Using an Integrated, Modular Reaction-Crystallization-Spherical Agglomeration-Filtration-Drying Process" was published by Rojan Parvaresh and Zoltan K Nagy in Organic Process Research & Development.
  • June 17, 2024: Rojan Parvaresh successfully defended her thesis: "Process Intensification of Integrated Continuous Crystallization Systems with Recycle". She was advised by Prof. Zoltan K. Nagy.
  • June 11, 2024 "Integrated Continuous Crystallization–-Spherical Agglomeration (CCSA) Process for the Intensified Manufacturing of Atorvastatin Calcium" was published by Rojan Parvaresh, Shumaiya Ferdoush, Shivani Kshirsagar, Marcial Gonzalez, and Zoltan K Nagy in Crystal Growth and Design.
  • June 2, 2024 CryPTSys group delivers a workhop on "Digital design of pharmaceutical processes using PharmaPy" at the joint ESCAPE34-PSE24 conference in Florence, Italy!
  • May 16, 2024 Congratulations to Montgomery Laky for winning the 2024 Marilyn Forney Trailblazer Award!
  • May 15, 2024 Congratulations to Aishwarya Menon and Urvi Mathur for getting the Summer Undergraduate Research Fellowhip (SURF)!
  • April 16, 2024 Congratulations to Inyoung and Montgomery for winning the Graduate Student Recognition Award!
  • April 15, 2024 CryptSys Group celebrates the union of Dr. Dan and Montgomery, and bids a fond farewell to Aybala, whose remarkable journey with us has inspired us all. Wishing them joy and success on their new journeys!
  • April 4, 2024 "OpenCrystalData: An open-access particle image database to facilitate learning, experimentation, and development of image analysis models for crystallization processes" was published by Yash Barhate, Christopher Boyle, Hossein Salami, Wei-Lee Wu, Nina Taherimakhsousi, Charlie Rabinowitz, Andreas Bommarius, Javier Cardona, Zoltan K. Nagy, Ronald Rousseau, Martha Grover in Digital Chemical Engineering.
  • March 29, 2024 "Semicontinuous Blending of Pharmaceutical Ingredients and the Impact of Process Parameters on the Blending Performance of an Integrated Feeder Blender Operating Semicontinuously" was published by Sumit Kumar, Yan-Shu Huang, Zoltan Nagy, Gintaras V Reklaitis, Marcial Gonzalez, Paul Mort in Advances in Materials Science and Engineering.
  • March 11, 2024 "Process Development and Kinetic Analysis in the Green Synthesis of Lomustine" was published by Giulia Murbach-Oliveira, Ilke Akturk, Zoltan Nagy, David H Thompson in Organic Process Research & Development.
  • February 16, 2024 Congratulations to Ilke for Being Selected as one of the five Finalist in the Dauch Center Digital Transformation Competition!
  • February 13, 2024 Monika, Montgomery, Ilke, Megha, Meng-Hua at the 2024 GWEN Symposium.
  • February 9, 2024 "Data‐driven identification of crystallization kinetics" was published by Baggie W Nyande, Zoltan K Nagy, Richard Lakerveld in AIChE Journal.
  • January 23, 2024 "Digital Design of an Agrochemical Crystallization Process via Two-Dimensional Population Balance Modeling" was published by Wei-Lee Wu, Christopher Chappelow, Navraj Hanspal, Paul A Larsen, Jasson Patton, Aaron Shinkle, Zoltan K Nagy in Organic Process Research & Development.
  • January 10, 2024 "Hybrid model development and nonlinear model predictive control implementation for continuous dry granulation process" was published by Yan-Shu Huang, Rexonni B Lagare, Phoebe Bailey, David Sixon, Marcial Gonzalez, Zoltan K Nagy, Gintaras V Reklaitis in Computers & Chemical Engineering.
  • December 29, 2023 "Population balance model enabled digital design and uncertainty analysis framework for continuous crystallization of pharmaceuticals using an automated platform with full recycle and minimal material use" was published by Yash Barhate, Hemalatha Kilari, Wei-Lee Wu, and Zoltan K. Nagy in Chemical Engineering Science.
  • November 23, 2023 "Digital design of an integrated purification system for continuous pharmaceutical manufacturing" was published by Inyoung Hur, Daniel Casas-Orozco, Daniel Laky, Francesco Destro, and Zoltan K. Nagy in Chemical Engineering Science.
  • November 8, 2023 Current and alumni members of the CryPTSys group at AIChE 2023 in Orlando, Florida!
  • October 1, 2023 "Developing a Modular Continuous Drug Product Manufacturing System with Real Time Quality Assurance for Producing Pharmaceutical Mini-Tablets" was published by Varun Sundarkumar, Wanning Wang, Madeline Mills, Zoltan K. Nagy, and Gintaras Reklaitis in Journal of Pharmaceutical Sciences.
  • September 25, 2023 "Manufacturing pharmaceutical mini-tablets for pediatric patients using drop-on-demand printing" was published by Varun Sundarkumar, Wanning Wang, Zoltan K. Nagy, and Gintaras Reklaitis in International Journal of Pharmaceutics.
  • September 19, 2023 "Sensor Fusion and Calibration-Based Adaptive Image Analysis Procedure for In Situ Crystal Size Measurement" was published by Wei-Lee Wu, Madeline M Mills, and Zoltan K. Nagy in Crystal Growth & Design.
  • September 6, 2023 Montgomery, Ilke, Prof. Nagy, Yash, and Yung-Shun at ISIC 2023 in Glascow, United Kingdom!
  • August 21, 2023 "Techno‐economic analysis of dynamic, end‐to‐end optimal pharmaceutical campaign manufacturing using PharmaPy," authored by Daniel Casas‐Orozco et al., has been featured on the front cover of AIChE journal, Volume 69, No. 9 . Congratulations to all the authors!
  • August 17, 2023 Congratulations to Montgomery Smith for winning 1st best Overall Poster at the 32nd annual Purdue GSO Symposium!
  • August 17, 2023 Congratulations to Yash Barhate for winning 5th best Overall Poster at the 32nd annual Purdue GSO Symposium!
  • July 6, 2023 Varun Sundarkumar successfully defended his thesis: " Advancing Dropwise Additive Manufacturing of Pharmaceuticals by Incorporating Continuous Processing, Novel Dosage Forms, and Industry 4.0 Capabilities ". He was advised by Prof. Gintaras Reklaitis and Prof. Zoltan K. Nagy.
  • July 5, 2023 Yan-Shu Huang successfully defended his thesis: " Advanced Process Control and Digital Twin Development for Continuous Pharmaceutical Manufacturing ". He was advised by Prof. Gintaras Reklaitis and Prof. Zoltan K. Nagy.
  • June 20, 2023 Hema, Inyoung, Prof. Reklaitis, Prof. Nagy, Varun, and Daniel at ESCAPE 2023 in Athens, Greece!
  • April 27, 2023 Congratulations to Yash Barhate for winning the Purdue Chemical Engineering Centennial Award!
  • April 27, 2023 Congratulations to Montgomery Smith for winning the Purdue Chemical Engineering Outstanding Teaching Assistant Award 2023!
  • April 3, 2023 Congratulations to Monika Neal for winning the College of Engineering Magoon Teaching Award 2023!
  • March 26, 2023 "Reaction kinetics determination and uncertainty analysis for the synthesis of the cancer drug lomustine" was published by Daniel Casas-Orozco, Daniel Laky, Jaron Mackey, Gintaras Reklaitis, and Zoltan K. Nagy in Chemical Engineering Science.
  • March 10, 2023 Sumit Kumar successfully defended his thesis: "Improving Blend Uniformity and Process Monitoring to Achieve Robust Oral Solids Manufacturing Processes ". He was advised by Prof. Gintaras Reklaitis and Prof. Zoltan K. Nagy.
  • February 16, 2023 "Considerations in Raman Spectroscopy for Real-Time API Concentration Measurement at Tablet Press Feed Frame" was published by Sumit Kumar, Zoltan K. Nagy, Gintaras V Reklaitis, Marcial Gonzalez in Journal of Spectroscopy.
  • February 7, 2023 Hema, Aybala, Montgomery, Ilke and Rojan at the 2023 GWEN Symposium. Congratulations to Montgomery for winning an international travel grant!
  • February 1, 2023 "Experimental Design for the Efficient Determination of the Crystallization Kinetics of a Polymorphic System in Combined Cooling and Antisolvent Crystallization" was published by Shivani Kshirsagar, Botond Szilagyi, and Zoltan K. Nagy in Crystal Growth & Design.
  • January 14, 2023 "Developing a virtual flowability sensor for monitoring a pharmaceutical dry granulation line" was published by Rexonni Lagare, Yan-Shu Huang, Zoltan K. Nagy, Gintaras Reklaitis, et al. in the Journal of Pharmaceutical Sciences.
  • January 1, 2023: "Continuous extraction of 2-chloroethyl isocyanate for 1-(2-chloroethyl)-3-cyclohexylurea purification" was published by Jaron Mackey, Zoltan K. Nagy, et al. in the Chemical Engineering and Processing - Process Intensification journal.
  • November 3, 2022: Prof. Zoltan Nagy received the Named Professorship honor for his accomplishments and successes at Purdue.
  • October 12, 2022: Shivani Kshirsagar successfully defended her thesis: "Process Intensification Techniques for Combined Cooling and Antisolvent Crystallization of Drug Substances". She was advised by Prof. Zoltan K. Nagy.
  • October 7, 2022: Wei-Lee Wu successfully defended his thesis: "Process intensification through control, optimization, and digitalization of crystallization systems". He was advised by Prof. Zoltan K. Nagy.
  • August 1, 2022: Jaron Mackey successfully defended his thesis: "MiniPharm: A Miniaturized Pharmaceutical Platform for Process Development". He was advised by Prof. Zoltan K. Nagy.
  • July 6, 2022: Daniel Laky successfully defended his thesis: "Optimization Techniques for Pharmaceutical Manufacturing and Design Space Analysis". He was advised by Prof. Gintaras Reklaitis, Prof. Carl Laird, and Prof. Zoltan K. Nagy.
More News from CryPTSys