School of Chemical Engineering

Crystallization and Particle Technology
Systems Engineering


CryPTSys Seminars

AIChE Annual Meeting 2024, San Diego, CA

Sunday October 27, 2024

  • Yash Barhate
    • Title: Developing Digital Twins for Pharmaceutical Crystallizations Processes Using Machine Learning-based Strategies
    • Session: Data-driven approaches, and ML/AI for pharmaceutical applications (PD2M)
    • Time: 5:36-5:57 PM
    • Location: Room 29C (Upper Level, SDCC)

Monday October 28, 2024

  • Montgomery Laky
    • Title: Process Control, Design, and Modeling of the steady state continuous crystallization of an Industrial Polymorphic Agrochemical
    • Plenary Session: Crystallization and Evaporation- Area 2B (Invited Talks)
    • Time: 1:38-1:58 PM
    • Location: Room 31C (Upper Level, SDCC)
  • Hemalatha Kilari
    • Title: Modeling and Experimental Investigation of Polymorphic Imatinib Mesylate Crystallization in Batch and Continuous Configurations
    • Session: Advances in Control Strategy using Modeling tools and approaches (PD2M)
    • Time: 3:30-3:48 PM
    • Location: Room 29D (Upper Level, SDCC)
  • Katherine Young
    • Title: Modeling Crystallization systems: Population balance approaches for structurally similar impurities with kinetically controlled impurity incorporation mechanisms
    • Session: Foreign Species and Crystallization: Impurity Rejection, Additives, Dopants, etc. (Separations & PD2M)
    • Time: 4:27-4:45 PM
    • Location: Room 31C (Upper Level, SDCC)

Tuesday October 29, 2024

  • Francesco Rossi
    • Title: Optimal, Individual Drug Dosing using Hybrid Pharmacokinetic models and Multi-Objective Dynamic Optimization under Uncertainty
    • Session: 10D: Applied Math for Biological and Biomedical systems (CAST)
    • Time: 9:12-9:30 AM
    • Location: Room 33C (Upper Level, SDCC)
  • Yung-Shun Kang
    • Title: Generalized workflow for model-free Quality-by-control: Recipe development and its implementation in Pharmaceutical Crystallization
    • Poster Session: Separations Division
    • Time: 3:30-5:00 PM
    • Location: Exhibit Hall GH (Ground Level, SDCC)
  • Kensaku Matsunami
    • Title: Development of Robust Design space for Integrated Pharmaceutical processes through Uncertainty Analysis
    • Session: Continuous Process: Next Generation Advancements (PD2M)
    • Time: 5:36-5:57 PM
    • Location: Room 29C (Upper Level, SDCC)

Wednesday October 30, 2024

  • Yung-Shun Kang
    • Title: Optimization-based Digital Design for Agglomeration Control of a Pharmaceutical Crystallization Process
    • Session: Modeling and Control of Crystallization (Separations and PD2M)
    • Time: 12:33-12:51 PM
    • Location: Room 31C (Upper Level, SDCC)
  • Almos Orosz
    • Title: Rapid development of Population balance models using an Automated Crystallization system integrated with the user-friendly modeling tool Crysiv
    • Session: Modeling and Control of Crystallization II (Separations and PD2M)
    • Time: 4:09-4:27 PM
    • Location: Room 31C (Upper Level, SDCC)
  • Monika Neal
    • Title: A Quality by Digital Design (QbD2) framework for the development of Intensified Crystallization systems
    • Session: Modeling and Control of Crystallization II (Separations and PD2M)
    • Time: 4:27-4:45 PM
    • Location: Room 31C (Upper Level, SDCC)
  • Montgomery Laky
    • Title: Investigation of Pre-Nucleation phenomena for strategic process design of an Industrial Agrochemical Antisolvent Crystallization experiencing unique phase separations
    • Session: Solid Form Characterization and Development: Cocrystals, salts, solvates, polymorphs, and beyond (Separations and PD2M)
    • Time: 1:09-1:27 PM
    • Location: Room 31C (Upper Level, SDCC)
  • Inyoung Hur
    • Title: Development of a Digital Twin for Dynamic Control of Crystalline Products in a Continuous Purification process using PharmaPy
    • Poster Session: General Poster Session
    • Time: 3:30-5:00 PM
    • Location: Exhibit Hall GH (Ground Level, SDCC)

ESCAPE 34-PSE 24, Florence, Italy

Sunday June 2, 2024

    Workshops
    • Title: Digital design of pharmaceutical processes using PharmaPy
    • Coordinators: Zoltan K Nagy, Gintaras Reklaitis, Yash Barhate, Jungsoo Rhim, Mohammad Shahab
    • Time: 9:00 AM -13:00

Monday June 3, 2023

    Jung-Soo Rhim
    • Title: Stochastic technoeconomic analysis and optimization of batch and continuous crystallization for sustainable pharmaceutical manufacturing under supply delays
    • Session: Process Optimization
    • Time: 11:40-13:00
    Mohammad Shahab
    • Title: Deep neural networks-based fault diagnosis model for process systems
    • Session: Process control and operations
    • Time: 14:30-16:30

Thursday June 6, 2023

    Yash Barhate
    • Title: Rule-based deicsion framework for the digital synthesis of optimal pharmaceutical processes
    • Session: AL/Machine learning
    • Time: 10:00-11:00
AIChE Annual Meeting 2023, Orlando, FL

Sunday November 5, 2023

    Montgomery Smith
    • Title: Process Intensification for Industrial Crystallizations Via Process Control and Design Strategie
    • Poster Session: Meet the Post-Doc Candidates Session
    • Time: 1:00-3:00 PM EST
    • Location: Hyatt Regency Orlando, Regency Ballroom R/S, Convention Level

Monday November 6, 2023

    Yung-Shun Kang
    • Title: A High-Performance Numerical Library for Solving Population Balance Equations for Crystallization Processes
    • Session: Advances in Engineering for Pharmaceutical Development and Manufacturing
    • Time: 12:30-12:52 PM EST
    • Location: Hyatt Regency Orlando, Celebration 6, Convention Level

    Varun Sundarkumar
    • Title: Continuous Manufacturing of Pharmaceutical Mini-Tablets for Pediatric Patients Using Drop-on-Demand Printing
    • Session: Continuous Processing in Drug Product
    • Time: 12:30-12:51 PM EST
    • Location: Hyatt Regency Orlando, Celebration 7, Convention Level

    Wei-Lee Wu
    • Title: Opencrystaldata: An Open-Access Crystal Image Database for Enabling the Image-Based Analysis of Crystallization Systems
    • Session: Crystallization and Evaporation
    • Time: 2:06-2:24 PM EST
    • Location: Hyatt Regency Orlando, Manatee Spring II, Lobby Level
    Baggie W. Nyande
    • Title: Population Balance Modeling of Kinetic-Controlled Incorporation of Structurally Related Impurities for Crystallization Systems
    • Session: Foreign Species and Crystallization, Impurity Rejection, Additives, Dopants, etc.
    • Time: 4:27-4:45 PM EST
    • Location: Hyatt Regency Orlando, Manatee Spring II, Lobby Level

Tuesday November 7, 2023

    Inyoung Hur
    • Title: Monitoring and Control of an Integrated Crystallization-Filtration-Drying Platform for Continuous Pharmaceutical Manufacturing
    • Poster Session: Meet the Industry Candidates Poster Session: Process & Product Development and Manufacturing in Chemicals & Pharmaceuticals
    • Time: 1:00-3:00 PM EST
    • Location: Hyatt Regency Orlando, Regency Ballroom R/S, Convention Level

    Montgomery Smith
    • Title: Process Intensification for Industrial Crystallizations Via Process Control and Design Strategies
    • Poster Session: Meet the Industry Candidates Poster Session: Process & Product Development and Manufacturing in Chemicals & Pharmaceuticals
    • Time: 1:00-3:00 PM EST
    • Location: Hyatt Regency Orlando, Regency Ballroom R/S, Convention Level
    Yash Barhate
    • Title: Reliable Design and Optimization of Crystallization Systems Under Uncertainty
    • Session: Systems and Process Operations
    • Time: 3:30-5:00 PM EST
    • Location: Hyatt Regency Orlando, Regency Ballroom R/S, Convention Level

Wednesday November 8, 2023

    Rojan Parvaresh
    • Title: Digital Design of the Continuous Crystallization of Atorvastatin Calcium
    • Session: Modeling and Control of Crystallization
    • Time: 8:21-8:39 AM EST
    • Location: Hyatt Regency Orlando, Manatee Spring II, Lobby Level

    Baggie W. Nyande
    • Title: Sparse Data-Driven Modeling of Crystallization Processes
    • Session: Modeling and Control of Crystallization
    • Time: 9:15-9:33 AM EST
    • Location: Hyatt Regency Orlando, Manatee Spring II, Lobby Level

    Ilke Akturk
    • Title: A Systematic Approach Using Model-Based Digital Design for Polymorphic Crystallization of Imatinib Mesylate
    • Session: Modeling and Control of Crystallization
    • Time: 9:51-10:09 AM EST
    • Location: Hyatt Regency Orlando, Manatee Spring II, Lobby Level

    Hemalatha Kilari
    • Title: A Systematic Model Development Framework for Batch Crystallization Using Iterative Model-Based Experimental Design Approach
    • Session: Crystallization and Precipitation of Pharmaceutical and Biological Molecules
    • Time: 1:09-1:27 PM EST
    • Location: Hyatt Regency Orlando, Manatee Spring II, Lobby Level

    Monika Neal
    • Title: Process Design and Intensification of a Continuous Modular Crystallization System
    • Session: Process Intensification and Modular ManufacturingL Intensified Reaction and Separation Processes
    • Time: 4:30-4:50 PM EST
    • Location: Hyatt Regency Orlando, Celebration 16, Convention Level

Thursday November 9, 2023

    Montgomery Smith
    • Title: Process Control and Design of the Continuous Crystallization of a Polymorphic Agrochemical
    • Session: Crystallization in Process Development
    • Time: 8:25-8:50 AM EST
    • Location: Hyatt Regency Orlando, Bayhill 19, Lobby Level
    Rojan Parvaresh
    • Title: Process Intensification and Integration of the Continuous Manufacturing of Atorvastatin Calcium Using Spherical Agglomeration
    • Session: Continuous Crystallization Processes
    • Time: 8:21-8:39 AM EST
    • Location: Hyatt Regency Orlando, Manatee Spring II, Lobby Level
    Yash Barhate
    • Title: Automated Model-Based Experimental Design Procedure for Robust Digital Twin Development for Continuous Crystallization Systems
    • Session: Continuous Crystallization Processes
    • Time: 8:57-9:15 AM EST
    • Location: Hyatt Regency Orlando, Manatee Spring II, Lobby Level

    Francesco Rossi
    • Title: Advances in Optimal, Individualized Drug Dosing Strategies, Based on Hybrid Models and Dynamic Optimization Under Uncertainty
    • Session: Design and Operations Under Uncertainty
    • Time: 4:14-4:36 PM EST
    • Location: Hyatt Regency Orlando, Bayhill 23, Lobby Level

    Varun Sundarkumar
    • Title: Development of a Digital Twin for the End-to-End Continuous Manufacturing of the Cancer Drug Lomustine
    • Session: Pharma 4.0 (Advanced Controls, Process Automation, Data Analytics, etc.) - Processes and Applications
    • Time: 4:36-4:58 PM EST
    • Location: Hyatt Regency Orlando, Celebration 8, Convention Level

    Inyoung Hur
    • Title: Nonlinear Model Predictive Control of an Integrated Continuous Purification System Using Pharmapy
    • Session: Pharma 4.0 (Advanced Controls, Process Automation, Data Analytics, etc.) - Processes and Applications
    • Time: 5:52-6:04 PM EST
    • Location: Hyatt Regency Orlando, Celebration 8, Convention Level

View Previous Seminars

Old CryPTSys News

  • November 30, 2021: Ayse Eren successfully defended her thesis: "Model-based Design of Pharmaceutical Crystallization Processes". She was advised by Prof. Zoltan K. Nagy.
  • June 23, 2020: Andrew Radcliffe successfully defends his thesis: "Development of Dropwise Additive Manufacturing with non-Brownian Suspensions: Applications of Computer Vision and Bayesian Modeling to Process Design, Monitoring and Control". He was advised by Prof. Gintaras Reklaitis and Prof Zoltan K. Nagy.
  • December 5, 2019: Sudarshan Ganesh successfully defends his thesis: "Continuous Pharmaceutical Manufacturing: Systems Integration for Process Operations Management". He was advised by Prof. Gintaras Reklaitis and Prof. Zoltan K. Nagy.
  • November 20, 2019: Kanjakha Pal successfully defends his thesis: "Process Intensification Enabling Direct Compression for Pharmaceutical Manufacturing: From Spherical Agglomeration to Precise Control of Co-agglomeration". He was advised by Prof. Zoltan K. Nagy.
  • August 1, 2019: Claire Liu successfully defends her thesis: "Modernizing drug substance manufacturing: continuous crystallization in traditional and innovative platforms". She was advised by Prof. Zoltan K. Nagy.
  • April 4, 2019: Joseph Oliva successfully defends his thesis: "Process Intensification Techniques for Continuous Spherical Crystallization in an Oscillatory Baffled Crystallizer with Online Process Monitoring". He was advised by Prof. Zoltan K. Nagy.
  • August 2, 2018: Mariana Moreno successfully defends her thesis: "Robust Process Monitoring for Continuous Pharmaceutical Manufacturing". She was coadvised by Prof. Ginataras Reklaitis and Prof. Zoltan K. Nagy.
  • August 3, 2017: Ramon Peña successfully defends his thesis: "Process Intensification through Spherical Crystallization: Novel Experimental and Modeling Approaches". He was advised by Prof. Zoltan K. Nagy.
  • April 3, 2017: David A. Acevedo successfully defends his thesis: "Development of Particle Size and Shape Manipulation Approaches for Crystallization Systems via Model Based Design and Process Intensification". He was advised by Prof. Zoltan K. Nagy.
  • March 6, 2017: Jennifer Lu successfully defends her thesis: "Impact of Biologically Relevant Bile Salts on Solution Crystallization". She was advised by Prof Zoltan K. Nagy, Prof. James D. Litster, and Prof. Lynne S. Taylor.