Here is a poster summarizing my lab's focus and a few videos related to the lab's work:

- Twin Screw Wet Granulation - Shankali Pradhan
- Liquid contact spreading in granular flows - Liza Easo
- Purdue's Continuous Tablet Manufacturing Pilot Plant - Mariana Moreno, Sudarshan Ganesh, and Yasasvi Bommireddy

My laboratory is part of Purdue's Center for Particulate Processes and Products (CP3).

In order to learn more about my research interests, I've provided a list of my graduate student thesis titles and abstracts, as well as a list of journal publications with links to abstracts. Lastly, I've summarized some of the research topics in which I'm currently involved along with my collaborators.

- Kumar, R., Sarkar, A., Ketterhagen, W., Hancock, B., Curtis, J., and Wassgren, C., 2018, "Influence of normal contact force model on simulations of sphero-cylindrical particles",
*AIChE Journal*, Accepted 02 Jan 2018. - Pradhan, S.U., Zhang, Y., Li, J., Litster, J.D., and Wassgren, C.R., 2018, "Tailored granule properties using 3D printed screw geometries in twin screw granulation",
*Powder Technology*, doi: 10.1016/j.powtec.2017.12.068. - Guo, Y., Wassgren, C., Curtis, J.S., and Xu, D., 2018, "A bonded sphero-cylinder model for the discrete element simulation of elasto-plastic fibers",
*Chemical Engineering Science*, Vol. 175, pp. 118-129. doi: 10.1016/j.ces.2017.09.029. - Ban, J., Kumar, R., Agarwal, S., and Wassgren, C, 2017, "Scaling inter-tablet coating variability in a horizontal rotating drum",
*AIChE Journal*, Vol., 63, No. 9, pp. 3743-3755, doi: 10.1002/aic.15758. - Pradhan, S.U., Sen, M., Li, J., Litster, J.D., and, Wassgren, C.R., 2017, "Granule breakage in twin screw granulation: Effect of material properties and screw element geometry",
*Powder Technology*, Vol. 315, pp. 290-299, doi:10.1016/j.powtec.2017.04.011. - Swaminathan, S., Ramey, B., Hilden, J., and Wassgren, C., 2017, "Characterizng the powder punch-face adhesive interaction during the unloading phase of powder compaction",
*Powder Technology*, Vol. 315, pp. 410-421, doi:10.1016/j.powtec.2017.04.003. - Guo, Y., Wassgren, C., Hancock, B., Ketterhagen, W., and Curtis, J., 2017, "Predicting breakage of high aspect ratio particles in an agitated bed using the discrete element method",
*Chemical Engineering Science*, Vol. 158, pp. 314 - 327. - Swaminathan, S., Hilden, J., Ramey, B., and Wassgren, C., 2016, "Modeling the formation of debossed features on a pharmaceutical tablet",
*Journal of Pharmaceutical Innovation*, Vol. 11, No. 3, pp. 214 - 230. - Dosta, M., Dale, S., Antonyuk, S., Wassgren, C.R., Heinrich, S., and Litster, J.D., 2016, "Numerical and experimental analysis of influence of granule microstructure on its compression breakage",
*Powder Technology*, Vol. 299, pp. 87 - 97. - Liu, Y. and Wassgren, C., 2016, "Modifications to Johanson's roll compaction model for improved relative density predictions",
*Powder Technology*, Vol. 297, pp. 294 - 302. - Khola, N. and Wassgren, C., 2015, "Correlations for shear-induced percolation segregation in granular shear flows",
*Powder Technology*, Vol. 288, pp. 441 - 452. - Mort, P., Michaels, J.N., Behringer, R.P., Campbell, C.S., Kondic, L., Kheiripour Langroudi, M., Shattuck, M., Tang, J., Tardos, G.I., and Wassgren, C., 2015, "Dense granular flow - A collaborative study",
*Powder Technology*, Vol. 284, pp. 571 - 584. - Hua, X., Curtis, J., Hancock, B., Ketterhagen, W., and Wassgren, C., 2015, "The internal loads, moments, and stresses in rod-like particles in a low-speed, vertical axis mixer",
*Chemical Engineering Science*, Vol. 134, pp. 581-598. - Yu, G., Wassgren, C., Hancock, B., Ketterhagen, W., and Curtis, J., 2015, "Computational study of granular shear flows of dry, flexible fibers using the discrete element method",
*Journal of Fluid Mechanics*. Vol. 775, pp. 24 - 52. - Freireich, B., Kumar, R., Ketterhagen, W., Su, K., Wassgren, C., and Zeitler, J.A., 2015, "Comparisons of intra-tablet coating variability using DEM simulations, asymptotic limit models, and experiments",
*Chemical Engineering Science*, Vol. 131, pp. 197-212. (Open Access) - Anand, A., Curtis, J., Wassgren, C., Hancock, B., and Ketterhagen, W., 2015, "Experimental study of wet cohesive particles discharging from a rectangular hopper",
*Industrial & Engineering Chemistry Research*, Vol. 54, No. 16, pp. 4545-4551. - Sarkar, A. and Wassgren, C., 2015, "Effect of particle size on flow and mixing in a bladed granular mixer",
*AIChE Journal*, Vol. 61, No. 1, pp. 46 - 57. - Kumar, R., Freireich, B., and Wassgren, C., 2015, "DEM-compartment-population balance model for particle coating in a horizontal rotating drum",
*Chemical Engineering Science*, Vol. 125, pp. 144-157. - Dale, S., Wassgren, C., and Litster, J., 2014, "Measuring granule phase volume distributions using x-ray microtomography",
*Powder Technology*, Vol. 264, pp. 550-560. - Kumar, R. and Wassgren, C., 2014, "Inter-particle coating variability in a continuous coater",
*Chemical Engineering Science*, Vol. 117, pp. 1-7. - Guo, Y., Wassgren, C., Ketterhagen, W., Hancock, B., and Curtis, J., 2013, "Validation and time step determination of discrete element modeling of flexible fibers,"
*Powder Technology*, Vol. 249, pp. 386-395. - Wang, T., Alston, K.M., Wassgren, C.R., Mockus, L., Catlin, A.C., Fernando, S.R., Fernando, S., Basu, P.K., and Hoag, S.W., 2013, "The creation of an excipient properties database to support Quality by Design (QbD) formulation development,"
*American Pharmaceutical Review*, Vol. 16, No. 4, pp. 16-25. - Barraso, D., Oka, S., Muliadi, A., Litster, J.D., Wassgren, C., and Ramachandran, R., 2013, "Population balance model validation and prediction of CQAs for continuous milling processes: Toward QbD in pharmaceutical drug product manufacturing,"
*Journal of Pharmaceutical Innovation*, Vol. 8, No. 3, pp. 147-162. - Guo, Y., Wassgren, C., Hancock, B., Ketterhagen, W., and Curtis, J., 2013, "Granular shear flows of flat disks and elongated rods without and with friction,"
*Physics of Fluids*, Vol. 25, Article 06334. - Hua, X., Curtis, J., Hancock, B., Ketterhagen, W., and Wassgren, C., 2013, "The kinematics of non-cohesive, sphero-cylindrical particles in a low-speed, vertical axis mixer,"
*Chemical Engineering Science*, Vol 101, pp. 144 - 164. - Li, J., Wassgren, C., and Litster, J.D., 2013, "Multi-scale modeling of a spray coating process in a paddle mixer/coater: The effect of particle size distribution on particle segregation and coating uniformity,"
*Chemical Engineering Science*, Vol. 95, pp. 203 - 210. - Kumar, R. and Wassgren, C., 2013, "Angular circulation speed of tablets in a vibratory tablet coating pan,"
*AAPS PharmSciTech*, Vol. 14, No. 1, pp. 339 - 351. - Muliadi, A., Wassgren, C., and Litster, J., 2012, "Validation of 3-D finite element analysis for predicting the density distribution of roll compacted pharmaceutical powder,"
*Powder Technology*, Vol. 237, pp. 386 - 399. - Guo, Y., Wassgren, C., Ketterhagen, W., Hancock, B., Benjamin, J., and Curtis, J., 2012, "A numerical study of granular shear flows of rod-like particles using the discrete element method,"
*Journal of Fluid Mechanics*, Vol. 713, pp. 1 - 26. - Guo, Y., Wassgren, C., Ketterhagen, B., Hancock, B., and Curtis, J., 2012, "Some computational considerations associated with discrete element modeling of cylindrical particles,"
*Powder Technology*, Vol. 228, pp. 193 - 198. - Kayrak-Talay, D., Dale, S., Wassgren, C., and Litster, J., 2012, "Quality by design for wet granulation in pharmaceutical processing: Assessing models for a priori design and scaling,"
*Powder Technology*, Vol. 240, pp. 7 - 18. - Sarkar, A. and Wassgren, C.R., 2012, "Comparison of flow microdynamics for a continuous granular mixer with predictions from periodic slice DEM simulations,"
*Powder Technology*, Vol. 221, pp. 325-336. - Li, J., Freireich, B.J., Wassgren, C.R., and Litster, J., 2013, "Experimental validation of a 2-D population balance model for spray coating processes,"
*Chemical Engineering Science*, Vol. 95, pp. 360 - 365. - Muliadi, A., Wassgren, C., and Litster, J., 2012, "Modeling the powder roll compaction process: Comparison of 2-D finite element method and the rolling theory for granular solids (Johanson's model),"
*Powder Technology*, Vol. 221, pp. 90 - 100. - Kodam, M., Curtis, J., Hancock, B., and Wassgren, C., 2012, "Discrete element method modeling of bi-convex pharmaceutical tablets: Contact detection algorithms and validation,"
*Chemical Engineering Science*, Vol. 69, No. 1, pp. 587 - 601. - Rao, A., Hancock, B., Wassgren, C., and Curtis, J.S., 2011, "Numerical simulation of dilute turbulent gas-particle flow with turbulence modulation,"
*AIChE Journal*, Vol. 58, No. 5, pp. 1381-1396. - Li, J., Freireich, B., Wassgren, C., and Litster, J., 2011, "A general compartment-based population balance model for particle coating and layered granulation,"
*AIChE Journal*, Vol. 58, No. 5, pp. 1397-1408. - Freireich, B., Li, J., Litster, J., and Wassgren, C., 2011, "Incorporating particle flow information from discrete element simulations in population balance models of mixer-coaters,"
*Chemical Engineering Science*, Vol. 66, No. 16, pp. 3592-3604. - Freireich, B., Ketterhagen, W.R., and Wassgren, C., 2011, "Intra-tablet coating variability for several pharmaceutical tablet shapes,"
*Chemical Engineering Science*, Vol. 66, No. 12, pp. 2535-2544. - Dubey, A., Sarkar, A., Ierapetritou, M., Wassgren, C.R., and Muzzio, F.J., 2011, "Computational approaches for studying the granular dynamics of continuous blending processes, 1-DEM based methods,"
*Macromolecular Materials and Engineering*, Vol. 296, Nos. 3-4, pp. 290-307. - Kodam, M., Bharadwaj, R., Curtis, J., Hancock, B., and Wassgren, C., 2010, "Cylindrical object contact detection for use in discrete element method simulations. Part II: Experimental Validation,"
*Chemical Engineering Science*, Vol. 65, No. 22, pp. 5863-5871. - Kodam, M., Bharadwaj, R., Curtis, J., Hancock, B., and Wassgren, C., 2010, "Cylindrical object contact detection for use in discrete element method simulations. Part I: Contact detection algorithms,"
*Chemical Engineering Science*, Vol. 65, No. 22, pp. 5852-5862. - Rao, A., Curtis, J.S., Hancock, B.C., and Wassgren, C., 2010, "Classifying the fluidization and segregation behavior of binary mixtures using particle size and density ratios,"
*AIChE Journal*, Vol. 57, No. 6, pp. 1446-1458. - Dechelette, A., Sojka, P.E., and Wassgren, C.R., 2010, "Non-Newtonian drops spreading on a flat surface,"
*Journal of Fluids Engineering*, Vol. 132, No. 10, Article 101302. - Sarkar, A. and Wassgren, C., 2010, "Continuous blending of cohesive granular material,"
*Chemical Engineering Science*, Vol. 65, No. 21, pp. 5687-5698. - Sinha, T., Curtis, J.S., Hancock, B.C., and Wassgren, C., 2010, "Finite element analysis of pharmaceutical tablet compaction using a density dependent material plasticity model,"
*Powder Technology*, Vol. 202, Nos. 1-3, pp. 46-54. - Sinha, T., Curtis, J.S., Hancock, B.C., and Wassgren, C., 2010, "A study on the sensitivity of Drucker-Prager Cap model parameters during the decompression phase of powder compaction simulations,"
*Powder Technology*, Vol. 198, No. 3, pp. 315-324. - Anand, A., Curtis, J.S., Wassgren, C.R., Hancock, B.C., and Ketterhagen, W.R., 2010, "Segregation of cohesive granular materials during discharge from a rectangular hopper,"
*Granular Matter*, Vol. 12, pp. 193-200. - Freireich, B., Kodam, M., and Wassgren, C., 2010, "An exact method for determining local solid fractions in discrete element method simulations,"
*AIChE Journal*, Vol. 56, No. 12, pp. 3036-3048. - Rao, A., Curtis, J.S., Hancock, B., and Wassgren, C., 2010, "The effect of column diameter and bed height on minimum fluidization velocity,"
*AIChE Journal*, Vol. 56, No. 9, pp. 2304-2311. - Freireich, B. and Wassgren, C., 2010, "Intra-particle coating variability: Analysis and Monte-Carlo simulations,"
*Chemical Engineering Science*, Vol. 65, pp. 1117-1124. - Anand, A., Curtis, J.S., Wassgren, C.R., Hancock, B.C., and Ketterhagen, W.R., 2009, "Predicting discharge dynamics of wet cohesive particles from a rectangular hopper using the discrete element method (DEM),"
*Chemical Engineering Science*, Vol. 64, No. 24, pp. 5268-5275. - Ketterhagen, W.R., Curtis, J.S., Wassgren, C.R., and Hancock, B.C., 2009, "Predicting the flow mode from hoppers using the discrete element method,"
*Powder Technology*, Vol. 195, No. 1, pp. 1-10. - Kodam, M., Bharadwaj, R., Curtis, J.S., Hancock, B.C., and Wassgren, C., 2009, "Force model considerations for glued sphere discrete element method simulations,"
*Chemical Engineering Science*, Vol. 64, No. 15, pp. 3466-3475. - Freireich, B., Litster, J., and Wassgren, C., 2009, "Using the discrete element method to predict collision-scale behavior: A sensitivity analysis,"
*Chemical Engineering Science*, Vol. 64, No. 15, pp. 3407-3416. - Kalbag, A. and Wassgren, C., 2009, "Inter-tablet coating variability: Tablet residence time variability,"
*Chemical Engineering Science*, Vol. 64, pp. 2705-2717. - Sarkar, A. and Wassgren, C.R., 2009, "Simulation of a continuous granular mixer: Effect of operating conditions on flow and mixing,"
*Chemical Engineering Science*, Vol. 64, pp. 2672-2682. - Anand, A., Curtis, J.S., Wassgren, C.R., Hancock, B.C., and Ketterhagen, W.R., 2008, "Predicting discharge dynamics from a rectangular hopper using the discrete element method (DEM),"
*Chemical Engineering Science*, Vol. 63, pp. 5821-5830. - Feng, T., Wang, F., Pinal, R., Wassgren, C., and Carvajal, M.T., 2008, "Investigation of the variability of NIR in-line monitoring of roller compaction process by using fast Fourier transform (FFT) analysis,"
*AAPS PharmSciTech.*, Vol. 9, No. 2, pp. 419-424. - Kalbag, A., Wassgren, C., Penumetcha, S.S., and Perez-Ramos, J.D., 2008, "Inter-tablet coating variability: Residence times in a horizontal pan coater,"
*Chemical Engineering Science*, Vol. 63, No. 11, pp. 2881-2894. - Ketterhagen, W.R., Curtis, J.S., Wassgren, C.R., and Hancock, B.C., 2008, "Modeling granular segregation in flow from quasi-three-dimensional wedge-shaped hoppers,"
*Powder Technology*, Vol. 179, pp. 126-143. - Pederson, B.M., Sadeghi, F., and Wassgren, C., 2007, "The effects of cage flexibility on ball-to-cage pocket contact forces and cage instability in deep groove ball bearings,"
*SAE 2006 Transactions Journal of Passenger Cars: Mechanical Systems*, Paper No. 2006-01-0358, pp. 260-271. - Ketterhagen, W.R., Curtis, J.S., Wassgren, C.R., Kong, A., Narayan, P.J., and Hancock, B.C., 2007, "Granular segregation in discharging cylindrical hoppers: A discrete element and experimental study,"
*Chemical Engineering Science*, Vol. 62, pp. 6423-6439. - Wassgren, C. and Curtis, J.S., 2006, "The application of computational modeling to pharmaceutical materials science,"
*MRS Bulletin*, Vol. 31, No. 11, pp. 900-904. - Bharadwaj, R., Wassgren, C., and Zenit, R., 2006, "The unsteady drag force on a cylinder immersed in a dilute granular flow,"
*Physics of Fluids*, Vol. 18, Art. 043301. - Duncan, M.R., Wassgren, C.R., and Krousgrill, C.M., 2005, "The damping performance of a single particle impact damper,"
*Journal of Sound and Vibration*, Vol. 286, pp. 123-144. - Ketterhagen, W.R., Curtis, J.S., and Wassgren, C.R., 2005, "Stress results from two-dimensional granular shear flow simulations using various collision models,"
*Physical Review E*, Vol. 71, Art. 061307. - Ghaisas, N., Wassgren, C.R., and Sadeghi, F.A., 2004, "Cage instabilities in cylindrical roller bearings,"
*Journal of Tribology*, Vol. 126, No. 4, pp. 681-689. - Arroyo-Cetto, D., Pulos, G., Zenit, R., Jimenez-Zapata, M.A., and Wassgren, C.R., 2003, "Compaction force in a confined granular column,"
*Physical Review E*, Vol. 68, Art. 051301. - Fernando, D. and Wassgren, C., 2003, "Effects of vibration method and wall boundaries on size segregation in granular beds,"
*Physics of Fluids*, Vol. 15, No. 11, pp. 3458-3467. - Wassgren, C.R., Cordova, J.A., Zenit, R., and Karion, A., 2003, "Dilute granular flow around an immersed cylinder,"
*Physics of Fluids*, Vol. 15, No. 11, pp. 3318-3330. - Chehata, D., Zenit, R., and Wassgren, C.R., 2003, "Dense granular flow around an immersed cylinder,"
*Physics of Fluids*, Vol. 15, No. 6, pp. 1622-1631. - Park, J. and Wassgren, C., 2003, "Modeling the dynamics of fabric in a rotating horizontal drum using the discrete element method,"
*International Journal of Particulate Science and Technology*, Vol. 21, No. 2, pp. 157-175. - Aphale, A., Bolander, N., Park, J., Shaw, L., Svec, J., and Wassgren, C., 2003, "Granular fertilizer particle dynamics on and off a spinner spreader,"
*Biosystems Engineering*, Vol. 85, No. 3, pp. 319-329. - Wassgren, C.R., Hunt, M.L., Freese, P.J., Palamara, J., and Brennen, C.E., 2002, "Effects of vertical vibration on hopper flows of granular material,"
*Physics of Fluids*, Vol. 14, pp. 3439-3448. - Shishodia, N. and Wassgren, C., 2001, "Buoyancy effects in vibro-fluidized beds,"
*Physical Review Letters*, Vol. 87, Article 084302. Shishodia, N. and Wassgren, C., 2002, "Erratum: Buoyancy effects in vibro-fluidized beds,"*Physical Review Letters*, Vol. 88, Article 109901(E). - Hunt, M.L., Weathers, R.C., Lee, A.T., Brennen, C.E., and Wassgren, C.R., 1999, "Effects of horizontal vibration on hopper flows of granular materials,"
*Physics of Fluids*, Vol. 11, No. 1, pp. 68-75. - Wassgren, C.R., Brennen, C.E., and Hunt, M.L., 1996, "Vertical vibration of a deep bed of granular material in a container,"
*Journal of Applied Mechanics*, Vol. 63, pp. 712-719. - Brennen, C.E., Ghosh, S., and Wassgren, C.R, 1996, "Vertical oscillation of a bed of granular material,"
*Journal of Applied Mechanics*, Vol. 63, pp. 156-161. - Su, G.W., Choi, D.U., Drean, R.J., Edelsohn, C.R., Gurley, J.G., Hagen, F.A., Landecker, P.B., Tillman, M.L., and Wassgren, C.R., 1993, "Engineering challenges for unmanned lunar exploration,"
*Space Technology*, Vol. 13, No. 4, pp. 395-401. - Burton, R.L and Wassgren, C., 1992, "Time-critical low-thrust orbit transfer optimization,"
*Journal of Spacecraft and Rockets*, Vol. 29, No. 2, pp. 286-288.

Collaborator(s) |
Affiliation |
Topic |

Andrew Cameron | Undergraduate student (Purdue University) | Powder blending experiments |

Christopher Dolan | Undergraduate student (Purdue University) | High shear wet granulation |

Rohit Kumar | Ph.D. student (Purdue University) | Breakage of rod-like particles |

Dr. Dhananjay Pai | Laboratory Manager (Purdue University) | High shear wet granulation |

Tom Palcheck | Undergraduate student (Purdue University) | Twin screw wet granulation |

Kunal Pradikar | Ph.D. student (Purdue University) | Multiscale modeling of biomass dynamics |

Jaiyu (Billy) Li | Undergraduate student (Purdue University) | Twin screw wet granulation |

Yu Liu | Ph.D. student (Purdue University) | Multiscale modeling of powder blending |

Shankali Pradhan | Ph.D. student (Purdue University) | Twin screw wet granulation |

Dr. Yu Guo Prof. Jennifer Curtis |
University of Florida UC-Davis |
Modeling flexible fibers |

- Currently no positions are available.