Time: 3-4 pm Eastern Time, Nov 8 (Friday), 2024

Location: MSEE 112

Zoom Link: https://purdue-edu.zoom.us/j/98798335169

Coffee and snacks will be provided.

A Control Chetaev Framework for Optical Tweezer-Based Unfolding of DNA 

Abstract: 

Considering the non-affine-in-control system governing the motion of a DNA molecule trapped inside an optical tweezer, this talk investigates the problem of closed-loop  unfolding of this biological molecule. We devise a control Chetaev function (CCF) framework to achieve the unfolding control objectives. Our solution relies on linearization of the  trapped DNA molecule dynamics with respect to the input (i.e., the position of the trap focus) and invoking an Artstein-Sontag-like universal formula. Furthermore, we derive conditions  for guaranteeing the boundedness of the unfolding control input, which affect the rate of DNA entropy-loss during unfolding. Numerical simulations on Worm Like Chain (WLC) models of DNA molecules demonstrate the effectiveness of the proposed control framework in the presence of external thermal disturbances. 

Speaker:

Mark W. Spong received the D.Sc. degrees in systems science and mathematics in 1981 from Washington University in St. Louis. He has held faculty positions at Lehigh University, Cornell University, the University of Illinois at Urbana-Champaign, and the University of Texas at Dallas. He is currently Professor of Systems Engineering and holds the Excellence in Education Chair at the University of Texas at Dallas.  From 2008-2017 he was the Dean of the Erik Jonsson School of Engineering and Computer Science at UT-Dallas.  Dr. Spong is Past President of the IEEE Control Systems Society and Fellow of both the IEEE and IFAC.  His main research interests are in robotics, mechatronics, and nonlinear control theory. He has authored or coauthored more than 300 technical articles in control and robotics, seven books and holds one patent. He has made fundamental contributions in robust and nonlinear control of robot manipulators, teleoperators, bipedal walking robots, and multi-robot systems. His notable awards include the 2020 Rufus Oldenberger Medal from the ASME, the 2018 Bode Lecture Prize from the IEEE Control Systems Society, the 2016 Nyquist Lecture Prize from the ASME, the 2011 Pioneer in Robotics Award from the IEEE Robotics and Automation Society, the  first IROS Fumio Harashima Award for Innovative Technologies in 2007, the IEEE Transactions on Control Systems Technology Outstanding Paper Award, the Senior Scientist Research Award from the Alexander von Humboldt Foundation, the Distinguished Member Award from the IEEE Control Systems Society, the John R. Ragazzini and O. Hugo Schuck Awards from the American Automatic Control Council, and the IEEE Third Millennium Medal. 

Organizers: Ziran Wang (ziran@purdue.edu), Nak-seung Patrick Hyun (nhyun@purdue.edu), & Yunyue Elita Li (elitali@purdue.edu)