Publications

Journals

2025

  1. Cui C, Xu Y, Aryal UK, Chen A, Chien S, You L, Li B, Yokota H (2025). Electrical Stimulation Generates Induced Tumor-Suppressing Cells, Offering a Potential Option for Combatting Breast Cancer and Bone Metastasis. Int J Mol Sci. 26(3):1030.
  2. Lin CY, Sassi Am Wu Y, Seaman K, Tang W, Song X, Bienenstock R, Yokota H. Sun Y, Geng F, Wang L, You L (2025). Mechanotransduction pathways regulate YAP nuclear translocation under Yoda1 and vibration in osteocytes. Bone 190: 117283.

2024

  1. Xing X, Huo Q, Cui Changpeng, Aryal UK, Ku B, Lim H, Liu J, Chen A, Rhomson WR, Li BY, and Yokota H (2024). Therapeutic insights into low-intensity vibration for generation of induced tumor-suppressive cells and modulating the bone microenvironment. Engineering 43:201-215.
  2. Yokota H, Li BY (2024). Exploring shaking for cancer treatment. Engineering 40:12-14.
  3. Cui C, Huo Q, Xiong X, Na S, Mitsuda M, Minami K, Li BY, Yokota H (2024). P18: Novel anticancer peptide from induced tumor-suppressing cells targeting breast cancer and bone metastasis. Cancers 16(12):2230,
  4. Xiong X, Huo Q, Li K, Cui C, Chang C, Park C, Ku BH, Hong CS, Lim HC, Pandya PH, Saadatzadeh MR, Bijangi-Vishehsaraei K, Lin CC, Kacena MA, Pollok KE, Chen A, Liu J, Thompson WR, Li XL, Li BY, Yokota H (2024). Enhancing anti-tumor potential: low-intensity vibration suppresses osteosarcoma progression and augments MSCs’ tumor-suppressive abilities. Theranostics 14(4):1430-1449.

2023

  1. Feng Y, Huo Q, Li BY, Yokota H (2023). Unveiling the dichotomy of urinary proteins: diagnostic insights into breast and prostate cancer and their roles. Proteomes 12(1), 1.
  2. Woollam M, Siegel AP, Munshi A, Liu S, Tholpady S, Gardner T, Li BY, Yokota H, Agarwal M (2023). Canine-inspired chemometric analysis of volatile organic compounds in urine headspace to distinguish prostate cancer in mice and men. Cancers (Basel) 15:1352.
  3. Cui C, Huo Q, Xiong X, Li K, Fishel ML, Li B, Yokota H (2023). Anticancer peptides derived from Aldolase A and induced tumor-suppressing cells inhibit pancreatic ductal adenocarcinoma cells. Pharmaceutics 15:2447.
  4. Li K, Huo Q, Minami K, Tamari K, Ogawa K, Na S, Fishel ML, Li BY, Yokota H (2023). Exploring the tumor-suppressing potential of PSCA in pancreatic ductal adenocarcinoma. Cancers (Basel) 15:4917.
  5. Huo Q, Li K, Sun X, Zhuang A, Minami K, Tamari K, Ogawa K, Fishel ML, Li BY, Yokota H (2023). The inhibition of pancreatic cancer progression by K-Ras overexpressing mesenchymal stem cell-derived secretomes. Sci Rep 13:15036.
  6. Cui CP, Huo QJ, Xiong X, Li KX, Ma P, Qiang GF, Pandya PH, SaadatzadehMR, Bijangi Vishehsaraei K, Kacena MA, Aryal UK, Pollok KE, Li BY, Yokota H. (2023). Anticancer peptides from induced tumor-suppressing cells for inhibiting osteosarcoma cells. Am J Cancer Res 13:4057-4072.
  7. Li K, Huo Q, Dimmitt NH, Qu G, Bao J, Pandya PH, Saadatzadeh MR, Bijangi-Vishehsaraei K, Kacena MA, Pollok KE, Lin CC, Li BY, Yokota H (2023). Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins. eLife 12:e83768.
  8. Li K, Huo Q, Li BY, Yokota H (2023). Three unconventional maxims in the natural selection of cancer cells: generation of induced tumor-suppressing cells (iTSCs). Int J Biol Sci 19:1403-1412.
  9. Woollam M, Siegel AP, Munshi A, Liu S, Tholpady S, Gardner T, Li BY, Yokota H, Agarwal M (2023). Canine-inspired chemometric analysis of volatile organic compounds in urine headspace to distinguish prostate cancer in mice and men. Cancers 15:1352.
  10. Li K, Sun X, Minami K, Tamari K, Ogawa K, Li H, Ma H, Zhou M, Na S, Li BY, Yokota H (2023). Proteomes from AMP-inhibited peripheral blood mononuclear cells suppress the progression of breast cancer and bone metastasis. Theranostics 13:1247-1263.
  11. Li K, Huo Q, Li BY, Yokota H (2023). The double-edged proteins in cancer proteomes and the generation of induced tumor-suppressing cells (iTSCs). Proteomes 11(1):5.
  12. Li J, Wang X, Li X, Liu D, Zhai L, Wang X, Kang R, Yokota H, Yang L, Zhang P (2023). Mechanical loading promotes the migration of endogenous stem cells and chondrogenic differentiation in a mouse model of osteoarthritis. Calcified Tissue International 112:363-376.
  13. Sun Y, Fang Y, Li X, Li J, Liu D, Wei M, Liao Z, Meng Y, Zhai L, Yokota H, Yang L, Yu Y, Zhang P (2023). A static magnetic field enhances the repair of osteoarthritic cartilage by promoting the migration of stem cells and chondrogenesis. J. Orthopaedic Translation 39:43-54.

2022

  1. Ahandoust S, Li K, Sun X, Li BY, Yokota H, Na S (2022). Intracellular and extracellular MSN differentially regulates Src activity and b-catenin translocation to the nucleus in breast cancer cells. Biochemical Biophysical Research Communications 639:62-69.
  2. Feng Y, Liu S, Zha R, Sun X, Li K, Wu D, Aryal UK, Koch M, Li BY, Yokota H (2022). Prostate cancer-associated urinary proteomes differ before and after prostatectomy. Therapeutic Advances in Med Oncology 14:17588359221131532.
  3. Li K, Sun X, Li H, Ma H, Zhou M, Minami K, Tamari K, Ogawa K, Pandya PH, Saadatzadeh MR, Kacena MA, Pollok KE, Li BY, Yokota H (2022). Suppression of osteosarcoma progression by engineered lymphocyte-derived proteomes. Genes & Dis 10:1641-1656.
  4. Sun X, Li K, Li BY, Yokota H (2022). Wnt signaling: a double-edged sword in protecting bone from cancer. J Bone Miner Metab doi: 10.1007/s00774-022-01363-1.
  5. Sun X, Li K, Aryal UK, Li BY, Yokota H (2022). PI3K-activated MSC proteomes inhibit mammary tumors via Hsp90ab1 and Myh9. Molecular Therapy Oncolytics 26:360-371.
  6. Sun X, Li K, Figueiredo ML, Lin CC, Li BY, Yokota H (2022). Generation of the chondroprotective proteomes by activating PI3K and TNFa signaling. Cancers 14:3039.
  7. Grocki P, Woollam M, Wang L, Liu S, Kalra M, Siegel AP, Li BY, Yokota H, Agarwal M (2022). Chemometric analysis of urinary volatile organic compounds to monitor the efficacy of pitavastatin treatments on mammary tumor progression over time. Molecules 27:4277.
  8. Marin AA, Decker RE, Kumar S, Lamantia Z, Yokota H, Emrick T, Figueiredo ML (2022). Enhancing prednisone-based arthritis therapy with targeted IL-27 gene delivery. Bioengineering 9:248.
  9. Zhang Y, Li X, Liu D, Zhai L, Wang X, Abdurahman A, Yokota H, Zhang P (2022). Knee loading enhances the migration of adipose-derived stem cells to the osteoarthritic sites through the SDF-1/CXR4 regulatory axis. Calcified Tissue Intl. 111:171-184.
  10. Li K, Sun X, Zha R, Liu S, Feng Y, Sano T, Aryal UK, Sudo A, Li BY, Yokota H (2022). Counterintuitive production of tumor-suppressive secretomes from Oct4- and c-Myc-overexpressing tumor cells and MSCs. Theranostics 12:3084-3103.
  11. Zhu L, Barber J, Zigon R, Na S, Yokota H. (2022). Modeling and simulation of interstitial fluid flow around an osteocyte canalicular network. Mathematics 34, 041906.
  12. Abdurahman A, Li X, Li J, Liu D, Zhai L, Wang X, Zhang Y, Meng Y, Yokota, H, Zhang P (2022). Loading-driven PI3K/Akt signaling and erythropoiesis enhanced angiogenesis and osteogenesis in a postmenopausal osteoporosis mouse model. Bone 157:116346.
  13. Sun X, Li K, Hase M, Zha R, Feng Y, Li BY, Yokota H (2022). Suppression of breast cancer-associated bone loss with osteoblast proteomes via Hsp90ab1/moesin-mediated inhibition of TGFb/FN1/CD44 signaling. Theranostics 12:929-943.
  14. Zheng W, Li X, Li J, Wang X, Liu D, Zhai L, Ding B, Li G, Sun Y, Yokota H, Zhang P (2022). Mechanical loading mitigates osteoarthritis symptoms by regulating the inflammatory microenvironment. Annals of the New York Academy of Sciences 1512:141-153.

2021

  1. Li K, Sun X, Li BY, Yokota H. (2021). Conversion of osteoclasts into bone-protective tumor-suppressing cells. Cancers 13, 5593.
  2. Liu S, Sun X, Li K, Lin CC, Na S, Li BY, Yokota H (2021). Tumor cell secretomes in response to anti- and pro-tumorigenic agents. Onco 1: 101-113.
  3. Liu S, Sun X, Li K, Zha R, Feng Y, Sano T, Dong C, Liu Y, Aryal UK, Sudo A, Li BY, Yokota H (2021). Generation of the tumor-suppressive secretome from tumor cells. Theranostics 11:8517-8534.
  4. Liu S, Wu D, Sun X, Fan Y, Zha R, Jalali A, Sano T, Vile N, Li F, Rispoli J, Sudo A, Liu J, Robling A, Nakshatri H, Li BY, Yokota H (2021). Overexpression of Lrp5 enhanced anti-breast cancer effects of osteocytes in the bone. Bone Research 9:32.
  5. Sun X, Li K, Zha R, Liu S, Fan Y, Wu K, Hase M, Aryal UK, Lin CC, Li BY, Yokota, H (2021). Preventing tumor progression to the bone by induced tumor-suppressing MSCs. Theranostics 1:5143-5159.
  6. Nguyen H, Xun S, Yokota H, Lin CC. Probing osteocyte function in gelatin hydrogels with tunable viscoelasticity. Biomacromolecles 22:1115-1126.
  7. Woollam M, Wang L, Grocki P, Liu S, Siegel AP, Kalra M, Goodpaster JV, Yokota H, Agarwal M (2021). Tracking the progression of triple negative mammary tumors over time by chemometric analysis of urinary volatile organic compounds. Cancers 13:1462.
  8. Huang M, Liu H, Zhu L, Li X, Li J, Liu S, Sng X, Yokota H, Zhang P (2021). Mechanical loading attenuates breast cancer-associate bone metastasis in obese mice by regulating the bone marrow microenvironment. J. Cellular Physiology 6:6391-6406.
  9. Sano T, Sun X, Feng Y, Liu S, Hase M, Fan Y, Zha R, Wu D, Aryal UK, Li BY, Sudo A, Yokota H (2021). Inhibition of the growth of breast cancer-associated brain tumors by the osteocyte-derived conditioned medium. Cancers 13:1061.
  10. Fan Y, Zha R, Sano T, Zhao X, Liu S, Woollam MD, Wu D, Sun X, Li K, Egi M, Li F, Minami K, Siegel A, Horiuchi T, Liu J, Agarwal M, Sudo A, Nakshatri H, Li B, Yokota H. (2021). Mechanical tibia loading remotely suppresses breast cancer-associated brain tumors by the dopamine-mediated downregulation of CCN4. Bone Research 9:26.
  11. Feng Y, Liu S, Zha R, Sun X, Li K, Robling A, Li BY, Yokota H. (2021). Mechanical loading-driven tumor suppression is mediated by Lrp5-dependent and independent mechanisms. Cancers 13:267.
  12. Wang X, Li X, Li J, Zhai L, Liu D, Abdurahman A, Zhang Y, Yokota H, Zhang P (2021). Mechanical loading stimulates bone angiogenesis through enhancing type H vessel formation and downregulating exosomal miR-214-3p from bone marrow derived mesenchymal stem cells. FASEB J 35:e21150.

2020

  1. Li J, Li X, Liu D, Zhang S, Tan N, Yokota H, Zhang P (2020). Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner. Cell Death & Disease 11:1069.
  2. Liu S, Wu D, Sun X, Fan Y, Zha R, Jalali A, Teli M, Sana T, Siegel A, Sudo A, Agarwal M, Robling A, Li BY, Yokota H (2020). Mechanical stimulations can inhibit local and remote tumor progression by downregulating WISP1. FASEB J 34:12847-12859.
  3. Davidson RK, Himes E, Takigawa S, Chen A, Horn MR, Meijome T, Wallace JM, Kacena MA, Yokota H, Nguyen A, Li J (2020). The loss of STAT3 in mature osteoclasts has detrimental effects on bone structure. PLOS One 15:e0236891.
  4. Woollam M, Teli M, Liu S, Daneshkhah A, Siegel AP, Yokota H, Agarwal M (2020). Urinary volatile terpenes analyzed by gas chromatography mass spectrometry to monitor breast cancer treatment efficacy in mice. J Proteome Res 5:1913-1922.
  5. Wu D, Fan Y, Liu S, Woollam MD, Sun X, Murao E, Zha R, Prakash R, Park C, Siegel AP, Liu J, Agarwal M, Li BY, Yokota H (2020). Loading-induced anti-tumor capability of murine and human urine. FASEB J 34:7578-7592.
  6. Neto MF, Liu S, Samameh JW, Yokota, H, Figueiredo ML (2020). Interleukin 27 gene delivery targeting IL6Ra expressing cells as a stress response therapy. Int. J. Mol Sci 21:E1108.
  7. Zheng W, Ding B, Li X, Liu D, Yokota H, Zhang P (2020). Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/b-catenin signaling. FASEB J 34:3399-3412.
  8. Fan Y, Jalali A, Chen A, Zhao X, Liu S, Teli M, Guo Y, Li F, Li J, Siegel A, Yang L, Liu J, Na S, Agarwal M, Robling AG, Nakshatri H, Li BY, Yokota H (2020). Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity dependent fashion. Bone Research 8:9.

Book chapters

Title Encyclopedia of Systems Biology
Editors Werner Dubitzky, Olaf Wolkenhauer, Hiroki Yokota, Kwang-Hyun Cho
Publisher Springer New York, 2013
ISBN 1441998640, 9781441998644
Length 2367 pages