M Koester, RE García, M Thommes “Spheronization process particle kinematics determined by discrete element simulations and particle image velocimetry measurements.” International Journal of Pharmaceutics, 477(1):81-87, 2014.
Abstract
Spheronization is an important pharmaceutical manufacturing technique to produce spherical agglomerates of 0.5–2 mm diameter. These pellets have a narrow size distribution and a spherical shape. During the spheronization process, the extruded cylindrical strands break in short cylinders and evolve from a cylindrical to a spherical state by deformation and attrition/agglomeration mechanisms. Using the discrete element method, an integrated modeling-experimental framework is presented, that captures the particle motion during the spheronization process. Simulations were directly compared and validated against particle image velocimetry (PIV) experiments with monodisperse spherical and dry γ-Al2O3 particles.
Like this:
Like Loading...
Related
D-W Chung, PR Shearing, NP Brandon, SJ Harris, RE García "Particle Size Polydispersity in Li-Ion Batteries." Journal of The Electrochemical Society, 161(3):A422-A430, 2014. Abstract Starting from three-dimensional X-ray tomography data of a commercial LiMn2O4 battery electrode, the effect of microstructure on the electrochemical and chemo-mechanical response of lithium-ion batteries is analyzed. Simulations…
In "Papers"
D. Weis, P. Grohn, M. Evers, M. Thommes, R.E. García, S. Antonyuk "Implementation of formation mechanisms in DEM simulation of the spheronization process of pharmaceutical pellets." Powder Technology 378: 667–679, (2021). https://doi.org/10.1016/j.powtec.2020.09.013 Abstract In the production process of pharmaceutical pellets with a narrow size distribution and a high sphericity, a combined…
In "Papers"
R García-García, RE García "Microstructural effects on the average properties in porous battery electrodes." Journal of Power Sources, 309:11-19, 2016. Abstract A theoretical framework is formulated to analytically quantify the effects of the microstructure on the average properties of porous electrodes, including reactive area density and the through-thickness tortuosity as observed…
In "Papers"
Related Posts:
- D. Weis, P. Grohn, M. Evers, M. Thommes, R.E. García, S.…
- D-W Chung, PR Shearing, NP Brandon, SJ Harris, RE García…
- DR Ely, RE García, M Thommes "Ostwald–Freundlich…
- R García-García, RE García "Microstructural effects on the…
- A. Deva, R.E. García "Apparent microstructurally induced…
- ACE Reid, SA Langer, RC Lua, VR Coffman, S-I Haan, RE García…
0 comments on “M Koester, RE García, M Thommes “Spheronization process particle kinematics determined by discrete element simulations and particle image velocimetry measurements.” International journal of pharmaceutics, 477(1):81-87, 2014.”Add yours →