Polymers, Colloids, and Nanobioengineering
Won Lab Research Homepage

School of Chemical Engineering
Purdue University











1.      “Nano Carriers That Enable Co-Delivery of Chemotherapy and RNAi Agents for Treatment of Drug-Resistant Cancers”, V. Tsouris, M. K. Joo, S. H. Kim, I. C. Kwon, Y.-Y. Won, Biotechnology Advances revision under review, 2014.

2.      “Macroscopic Lateral Heterogeneity Observed in a Laterally-Mobile Immiscible Mixed Polyelectrolyte/Neutral Polymer Brush”, H. Lee, V. Tsouris, Y. Lim, R. Mustafa, J. Choi, Y. H. Choi, H.-W. Park, M. Meron, B. Lin, Y.-Y. Won, Soft Matter in press, 2014.

3.      "A Photo-Degradable Gene Delivery System for Enhanced Nuclear Gene Transcription", H. Lee, Y. Kim, P. G. Schweickert, S. F. Konieczny, Y.-Y. Won, Biomaterials 35(3), 1040-1049, 2014.

4.      ""pH Phoresis": A New Concept That Can Be Used for Improving Drug Delivery to Cancer Cells", Y.-Y. Won, H. Lee, Journal of Controlled Release 170(3), 396-400, 2013. See "Nanoparticles, 'pH phoresis' could improve cancer drug delivery" in Purdue News (July 8, 2013).

5.      "The Effect of N/P Ratio on the In Vitro and In Vivo Interaction Properties of PEGylated Poly(2-(dimethylamino)ethyl methacrylate)-Based siRNA Complexes", D. J. Gary, J. Min, Y. Kim, K. Park, Y.-Y. Won, Macromolecular Bioscience 13(8), 1059-1071, 2013.

6.      "Study of the Air-Water Interfacial Properties of Biodegradable Polyesters and Their Block Copolymers with Poly(ethylene glycol)", H. W. Park, J. Choi, K. Ohn, H. Lee, J. W. Kim, Y.-Y. Won, Langmuir 28(31), 11555-11566, 2012.

7.      "Water is a Poor Solvent for Densely Grafted Poly(ethylene oxide) Chains: A Conclusion Drawn from a Self-Consistent Field Theory-Based Analysis of Neutron Reflectivity and Surface Pressure-Area Isotherm Data", H. Lee, D. H. Kim, K. N. Witte, K. Ohn, J. Choi, B. Akgun, S. Satija, Y.-Y. Won, Journal of Physical Chemistry B 116(24), 7367-7378, 2012.

8.      "Reduced Water Density in Poly(ethylene oxide) Brushes", H. Lee, D. H. Kim, H.-W. Park, K. Kim, M. Meron, B. Lin, Y.-Y. Won, Journal of Physical Chemistry Letters 3, 1589-1595, 2012.

9.      "Preparation of Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micelles", D. H. Kim, A. Wei, Y.-Y. Won, ACS Applied Materials & Interfaces 4(4), 1872-1877, 2012.

10.  "Confinement Induced Lateral Segregation of Polymer Coated Nanospheres", R. Nap, Y.-Y. Won, I. Szleifer, Soft Matter 8(5), 1688-1700, 2012.

11.  "In Situ-Polymerized Carbon Nanotube/Polyimide Nanocomposites: Effect of Reaction Stoichiometry on the Glass Transition Properties of the Nanocomposites", D. H. Kim, Y.-Y. Won, Macromolecular Reaction Engineering 6(1), 45-56, 2012. This article has been highlighted on the front cover of the journal. Please contact the corresponding author for a reprint.

12.  "Influence of Nano-Carrier Architecture on In Vitro siRNA Delivery Performance and In Vivo Biodistribution: Polyplexes vs. Micelleplexes", D. J. Gary, H. Lee, R. Sharma, J.-S. Lee, Y. Kim, Z. Y. Cui, D. Jia, V. D. Bowman, P. R. Chipman, L. Wan, Y. Zou, G. Mao, K. Park, B.-S. Herbert, S. F. Konieczny, Y.-Y. Won, ACS Nano 5(5), 3493–3505, 2011.

13.  "A Discussion of the pH-Dependent Protonation Behaviors of Poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) and Poly(ethylenimine-ran-2-ethyl-2-oxazoline) (P(EI-r-EOz))", H. Lee, S. H. Son, R. Sharma, Y.-Y. Won, Journal of Physical Chemistry B 115(5), 844–860, 2011.

14.  "Effects of the Molecular Weight and Concentration of Polymer Additives, and Temperature on the Melt Crystallization Kinetics of a Small Drug Molecule", U. S. Kestur, H. Lee, D. Santiago, C. Rinaldi, Y.-Y. Won, L. S. Taylor, Crystal Growth & Design 10(8), 3585-3595, 2010.

15.  "Crystallization of Bidisperse Repulsive Colloids in Two-Dimensional Space: A Study of Model Systems Constructed at the Air-Water Interface", J. Hur, N. A. Mahynski, Y.-Y. Won, Langmuir 26(14), 11737-11749, 2010.

16.  "Formation and Collapse of Single-Monomer-Thick Monolayers of Poly(n-Butyl Acrylate) at the Air-Water Interface", K. N. Witte, S. Kewalramani, I. Kuzmenko, W. Sun, M. Fukuto, Y.-Y. Won, Macromolecules 43(6), 2990-3003, 2010.

17.  "On the Origins of the Salt-Concentration-Dependent Instability and Lateral Nanoscale Heterogeneities of Weak Polyelectrolyte Brushes: Gradient Brush Experiment, and Flory-Type Theoretical Analysis", J. Hur, K. N. Witte, W. Sun, Y.-Y. Won, Langmuir 26(3), 2021-2034, 2010.

18.  "Missing Pieces in Understanding the Intracellular Trafficking of Polycation/DNA Complexes", Y.-Y. Won, R. Sharma, S. F. Konieczny, Journal of Controlled Release 139(2), 88-93, 2009. Please note that a corrigendum has been published.

19.  "Self-Consistent Field Theory Study of the Effect of Grafting Density on the Height of a Weak Polyelectrolyte Brush", K. N. Witte, S. Kim, Y.-Y. Won, Journal of Physical Chemistry B 113(32), 11076-11084, 2009.

20.  "Evidence of Lateral Nanoscale Heterogeneities in Weak Polyelectrolyte Brushes", K. N. Witte, J. Hur, W. Sun, S. Kim, Y.-Y. Won, Macromolecules 41(23), 8960-8963, 2008.

21.  "Effects of the Incorporation of a Hydrophobic Middle Block into a PEG-Polycation Diblock Copolymer on the Physicochemical and Cell Interaction Properties of the Polymer-DNA Complexes", R. Sharma, J.-S. Lee, R. C. Bettencourt, C. Xiao, S. F. Konieczny, Y.-Y. Won, Biomacromolecules 9(11), 3294-3307, 2008.

22.  "Fabrication of High-Quality Non-Close-Packed 2D Colloid Crystals by Template-Guided Langmuir-Blodgett Particle Deposition", J. Hur, Y.-Y. Won, Soft Matter 4(6), 1261-1269, 2008. See "Self-assembling Method Could Lead to Inexpensive Diamond-like Crystals for Technology" in ScienceDaily (April 22, 2008). This article was one of the ten most downloaded Soft Matter articles for April 2010 (http://www.rsc.org/publishing/journals/sm/top10.asp).

23.  "Two-Dimensional Colloid Crystals Templated by Polyelectrolyte Multilayer Patterns", J. Hur, Y.-Y. Won, Langmuir 24(10), 5382-5392, 2008.

24.  "Effect of Interfacial Curvature on the Miscibility of Laterally Mobile, Mixed Polyelectrolyte and Neutral Polymer Brushes: An SCF Numerical Analysis", K. N. Witte, Y.-Y. Won, Macromolecules 41(7), 2735-2738, 2008.

25.  "Preparation of Calcium Alginate Microgel Beads in an Electrodispersion Reactor Using an Internal Source of Calcium Carbonate Nanoparticles", Y. Zhao, M. T. Carvajal, Y.-Y. Won, M. T. Harris, Langmuir 23(25), 12489-12496, 2007.

26.  "Application of Molecular Rotors to the Determination of the Molecular Weight-Dependence of Viscosity in Polymer Melts", D. Zhu, M. A. Haidekker, J.-S. Lee, Y.-Y. Won, J. C.-M. Lee, Macromolecules 40(21), 7730-7732, 2007.

27.  "Polymer-Based siRNA Delivery: Perspectives on the Fundamental and Phenomenological Distinctions from Polymer-Based DNA Delivery", D. J. Gary, N. Puri, Y.-Y. Won, Journal of Controlled Release 121(1-2), 64-73, 2007. As of May 2010, this article has been cited more than 50 times.

28.  "Nonionic Block Copolymer Wormlike Micelles", Y.-Y. Won, F. S. Bates, in Giant Micelles: Properties and Applications (Editors: R. Zana, E. W. Kaler), CRC Press/Taylor & Francis, Boca Raton, FL, 2007.

29.  "Self-Consistent-Field Analysis of Mixed Polyelectrolyte and Neutral Polymer Brushes", K. N. Witte, Y.-Y. Won, Macromolecules 39(22), 7757-7768, 2006.

30.  "Inhibitive Chain Transfer to Ligand in the ATRP of n-Butyl Acrylate", R. Sharma, A. Goyal, J. M. Caruthers, Y.-Y. Won, Macromolecules 39(14), 4680-4689, 2006.

31.  "Effect of Temperature on Carbon Black Agglomeration in Hydrocarbon Liquid with Adsorbed Dispersant", Y.-Y. Won, S. P. Meeker, V. Trappe, D. A. Weitz, N. Z. Diggs, J. I. Emert, Langmuir 21(4), 924-932, 2005.

32.  "Rubbery Graft Copolymer Electrolytes for Solid-State, Thin-Film Lithium Batteries", P. E. Trapa, Y.-Y. Won, S. C. Mui, E. A. Olivetti, B. Huang, D. R. Sadoway, A. M. Mayes, S. Dallek, Journal of the Electrochemical Society 152(1), A1-A5, 2005.

33.  "Imaging Nanostructured Fluids Using Cryo-TEM", Y.-Y. Won, Korean Journal of Chemical Engineering 21(1), 296-302, 2004. This article has been referenced in an STTR call from the US Army, titled “Nanoscale In-Solution TEM Sample Stage with Manipulation Capability (A08-T029)” (January 22, 2008). Please contact the author for a reprint.

34.  "Molecular Exchange in PEO-PB Micelles in Water", Y.-Y. Won, H. T. Davis, F. S. Bates, Macromolecules 36(3), 953-955, 2003.

35.  "Effect of Surfactant on Unilamellar Polymeric Vesicles: Altered Membrane Properties and Stability in the Limit of Weak Surfactant Partitioning", M. M. Santore, D. E. Discher, Y.-Y. Won, F. S. Bates, D. A. Hammer, Langmuir 18(20), 7299-7308, 2002.

36.  "ATRP of Amphiphilic Graft Copolymers Based on PVDF and Their Use as Membrane Additives", J. F. Hester, P. Banergee, Y.-Y. Won, A. Akthakul, M. H. Acar, A. M. Mayes, Macromolecules 35(20), 7652-7661, 2002.

37.  "Block Copolymer Electrolytes Synthesized by Atom Transfer Radical Polymerization for Solid-State, Thin-Film Lithium Batteries", P. E. Trapa, B. Huang, Y.-Y. Won, D. R. Sadoway, A. M. Mayes, Electrochemical and Solid-State Letters 5(5), A85-A88, 2002.

38.  "Cryogenic Transmission Electron Microscopy (Cryo-TEM) of Micelles and Vesicles Formed in Water by Poly(ethylene oxide)-Based Block Copolymers", Y.-Y. Won, A. K. Brannan, H. T. Davis, F. S. Bates, Journal of Physical Chemistry B 106(13), 3354-3364, 2002.

39.  "Crosslinked

 Polymersome Membranes: Vesicles with Broadly Adjustable Stability

", B. M. Discher, H. Bermudez, D. A. Hammer, D. E. Discher, Y.-Y. Won, F. S. Bates, Journal of Physical Chemistry B 106(11), 2848-2854, 2002.

40.  "Comparison of Original and Cross-linked Wormlike Micelles of Poly(ethylene oxide-b-butadiene) in Water: Rheological Properties and Effects of Poly(ethylene oxide) Addition", Y.-Y. Won, K. Paso, H. T. Davis, F. S. Bates, Journal of Physical Chemistry B 105(35), 8302-8311, 2001.

41.  "Preparation, Stability, and In Vitro Performance of Vesicles Made from Diblock Copolymers", J. C.-M. Lee, H. Bermudez, B. M. Discher, M. Sheehan, Y.-Y. Won, F. S. Bates, D. E. Discher, Biotechnology and Bioengineering 73(2), 135-145, 2001.

42.  "Thermogelling Biodegradable Polymers with Hydrophilic Backbones: PEG-g-PLGA", B. Jeong, M. R. Kibbey, J. C. Birnbaum, Y.-Y. Won, A. Gutowska, Macromolecules 33(22), 8317-8322, 2000.

43.  "Segment Distribution of the Micellar Brushes of Poly(ethylene oxide) via Small-Angle Neutron Scattering", Y.-Y. Won, H. T. Davis, F. S. Bates, M. Agamalian, G. D. Wignall, Journal of Physical Chemistry B 104(30), 7134-7143, 2000. Minor corrections have been made to the article: Journal of Physical Chemistry B 104(38), 9054-9054, 2000.

44.  "Directly Resolved Core-Corona Structure of Block Copolymer Micelles by Cryo-Transmission Electron Microscopy", Y. Zheng, Y.-Y. Won, F. S. Bates, H. T. Davis, L. E. Scriven, Y. Talmon, Journal of Physical Chemistry B 103(47), 10331-10334, 1999.

45.  "Polymersomes: Vesicles Made from Diblock Copolymers", B. M. Discher, Y.-Y. Won, J. C.-M. Lee, J. Eggs, F. S. Bates, D. E. Discher, D. A. Hammer, Science 284 (5417), 1143-1146, 1999.

46.  "Giant Wormlike Rubber Micelles", Y.-Y. Won, H. T. Davis, F. S. Bates, Science 283 (5404), 960-963, 1999.