WON LABORATORY AT PURDUE UNIVERSITY

 

Our laboratory studies problems fundamental to developing new improved ways to treat cancer and respiratory distress. Areas of focus include: (1) development of nanoparticle therapeutics (immunogenic radiosensitizers and fully synthetic pulmonary surfactants) and polymer-based controlled release drug/gene delivery systems, (2) investigations on interfacial phenomena of polymers (with emphasis on Langmuir monolayers of polymers, block copolymer micelles, and polymer/polyelectrolyte brushes), (3) understanding of the complex behavior of charged polymers (ʺpolyelectrolytesʺ), and (4) fabrication of complex functional structures by self-assembly of block copolymers and colloids. Links to individual publications are available at the Google Scholar page (https://scholar.google.com/citations?hl=en&user=xrm0ATF9pvUC&view_op=list_works&sortby=pubdate).

 

 

REFEREED JOURNAL PUBLICATIONS

 

1)         Daniel J. Fesenmeier, Madathilparambil V. Suresh, Seyoung Kim, Krishnan Raghavendran, You-Yeon Won, ʺPolymer Lung Surfactant Therapy Reduces Lung Injury and Inflammation in Mouse Models of Direct Lung Injuryʺ, submitted, 2022.

 

2)         Yun Chang, Xuechao Cai, Ramizah Syahirah, Yuxin Yao, Yang Xu, Gyuhyung Jin, Vijesh J. Bhute, Sandra Torregrosa-Allen, Bennett D. Elzey, You-Yeon Won, Qing Deng, Xiaoguang Wang, Omolola Eniola-Adefeso, Xiaoping Bao, ʺBlood-Brain Barrier-Penetrating CAR Neutrophil-Mediated Delivery of Tumor Microenvironment-Responsive Nanodrugs for Effective and Safe Glioblastoma Chemoimmunotherapyʺ, submitted, 2022.

 

3)         Dhushyanth Viswanath, You-Yeon Won, ʺCombining Radiotherapy (RT) and Photodynamic Therapy (PDT): Clinical Studies on Conventional RT-PDT Approaches, and Novel Nanoparticle-Based RT-PDT Approaches under Preclinical Evaluationʺ, ACS Biomaterials Science & Engineering accepted/in press, 2022 (DOI: 10.1021/acsbiomaterials.2c00287).

 

4)         Kaustabh Sarkar, Sandra E. Torregrosa-Allen, Bennett D. Elzey, Sanjeev Narayanan, Mark P. Langer, Gregory A. Durm, You-Yeon Won, ʺEffect of Paclitaxel Stereochemistry on X-ray-Triggered Release of Paclitaxel from CaWO4/Paclitaxel-Coloaded PEG-PLA Nanoparticlesʺ, Molecular Pharmaceutics 19(8), 2776-2794, 2022 (DOI: 10.1021/acs.molpharmaceut.2c00148).

 

5)         Seyoung Kim, Daniel J. Fesenmeier, Sungwan Park, Sandra E. Torregrosa-Allen, Bennett D. Elzey, You-Yeon Won, ʺPulmonary Pharmacokinetics of Polymer Lung Surfactants Following Pharyngeal Administration in Miceʺ, Biomacromolecules 23(6), 2471-2484, 2022 (DOI: 10.1021/acs.biomac.2c00221).

 

6)         Daniel J. Fesenmeier, Sungwan Park, Seyoung Kim, You-Yeon Won, ʺSurface Mechanical Behavior of Water-Spread Poly(styrene)-Poly(ethylene glycol) (PS-PEG) Micelles at the Air-Water Interface: Effect of Micelle Size and Polymer End/Linking Group Chemistryʺ, Journal of Colloid and Interface Science 617, 764-777, 2022 (DOI: 10.1016/j.jcis.2022.03.008).

 

7)         Jin Yoo, Dhushyanth Viswanath, You-Yeon Won, ʺStrategy for Synthesis of Statistically Sequence-Controlled PEG-PLGA, and Effects of Sequence Distribution on Interaction and Drug Release Propertiesʺ, ACS Macro Letters 10, 1510-1516, 2021 (DOI: 10.1021/acsmacrolett.1c00637).

 

8)         Samruddhi Patil, Jin Yoo, You-Yeon Won, ʺInvestigation of the Mechanisms and Kinetics of DBU-Catalyzed PLGA Copolymerization via a Full-Scale Population Balance Analysisʺ, Industrial & Engineering Chemistry Research 60(41), 14865-14700, 2021 (DOI: 10.1021/acs.iecr.1c03096).

 

9)         Anish P. Patel, Christopher R. Schorr, Dhushyanth Viswanath, Kaustabh Sarkar, Natalie J. Streb, Vincenzo J. Pizzuti, Rahul Misra, Jaewon Lee, You-Yeon Won, ʺPilot-Scale Optimization of the Solvent Exchange Production and Lyophilization Processing of PEG-PLA Block Copolymer-Encapsulated CaWO4 Radioluminescent Nanoparticles for Theranostic Applicationsʺ, Industrial & Engineering Chemistry Research 60(19), 7082-7096, 2021 (DOI: 10.1021/acs.iecr.0c05852).

 

10)      Y.-Y. Won, D. Ramkrishna, ʺAddition to ʺRevised Formulation of Fickʹs, Fourierʹs, and Newtonʹs Laws for Spatially Varying Linear Transport Coefficientsʺʺ, ACS Omega 5(51), 33484-33487, 2020 (DOI: 10.1021/acsomega.0c02856).

 

11)      J. Yoo, Y.-Y. Won, ʺPhenomenology of the Initial Burst Release of Drugs from PLGA Microparticlesʺ, ACS Biomaterials Science & Engineering 6(11), 6053-6062, 2020 (DOI: 10.1021/acsbiomaterials.0c01228).

 

12)      D. W. Kim, G. A. Medvedev, J. M. Caruthers, J. Y. Jo, Y.-Y. Won, J. Kim, ʺEnhancement of Mechano-Sensitivity for Spiropyran-Linked Poly(dimethylsiloxane) via Solvent Swellingʺ, Macromolecules 53(18), 7954-7961, 2020 (DOI: 10.1021/acs.macromol.0c00985).

 

13)      V. J. Pizzuti, D. Viswanath, S. E. Torregrosa-Allen, M. P. Currie, B. D. Elzey, Y.-Y. Won, ʺBilirubin-Coated Radio-Luminescent Particles for Radiation-Induced Photodynamic Therapyʺ, ACS Applied Bio Materials 3(8), 4858-4872, 2020 (DOI: 10.1021/acsabm.0c00354).

 

14)      J. Lee, J. Pan, J. Chun, Y.-Y. Won, ʺUnexpected Conformational Behavior of Poly(poly(ethylene glycol) methacrylate)-Poly(propylene carbonate)-Poly(poly(ethylene glycol) methacrylate) (PPEGMA-PPC-PPEGMA) Amphiphilic Block Copolymers in Micellar Solution and at the Air-Water Interfaceʺ, Journal of Colloid and Interface Science 566, 304-315, 2020 (DOI: 10.1016/j.jcis.2020.01.080). Corrigendum: Journal of Colloid and Interface Science 586, 596, 2021 (DOI: 10.1016/j.jcis.2020.10.126).

 

15)      V. J. Pizzuti, R. Misra, J. Lee, S. E. Torregrosa-Allen, M. P. Currie, S. R. Clark, A. P. Patel, C. R. Schorr, Y. Jones-Hall, M. O. Childress, J. M. Plantenga, N. J. Rancilio, B. D. Elzey, Y.-Y. Won, ʺFolic Acid-Conjugated Radioluminescent Calcium Tungstate Nanoparticles as Radio-Sensitizers for Cancer Radiotherapyʺ, ACS Biomaterials Science & Engineering 5(9), 4776-4789, 2019 (DOI: 10.1021/acsbiomaterials.9b00773).

 

16)      Y.-Y. Won, D. Ramkrishna, ʺRevised Formulation of Fickʹs, Fourierʹs, and Newtonʹs Laws for Spatially Varying Linear Transport Coefficientsʺ, ACS Omega 4(6), 11215-11222, 2019 (DOI: 10.1021/acsomega.9b00736).

 

17)      R. Misra, K. Sarkar, J. Lee, V. J. Pizzuti, D. S. Lee, M. P. Currie, S. E. Torregrosa-Allen, D. E. Long, G. A. Durm, M. P. Langer, B. D. Elzey, Y.-Y. Won, ʺRadioluminescent Nanoparticles for Radiation-Controlled Release of Drugsʺ, Journal of Controlled Release 303, 237-252, 2019 (DOI: 10.1016/j.jconrel.2019.04.033).

 

18)      B. Chun, J. S. Park, H. W. Jung, Y.-Y. Won, ʺShear-Induced Particle Migration and Segregation in Non-Brownian Bidisperse Suspensions under Planar Poiseuille Flowʺ, Journal of Rheology 63(3), 437-453, 2019 (DOI: 10.1122/1.5065406).

 

19)      H. C. Kim, M. V. Suresh, V. V. Singh, D. Q. Arick, D. A. Machado-Aranda, K. Raghavendran, Y.-Y. Won, ʺPolymer Lung Surfactantsʺ, ACS Applied Bio Materials 1(3), 581-592, 2018 (DOI: 10.1021/acsabm.8b00061).

 

20)      J. Lee, S. D. Jo, H. Chung, W. Um, R. Chandrasekar, Y. H. Choi, V. M. Shalaev, Y.-Y. Won, ʺLaser-Induced CO2 Generation from Gold Nanorod-Containing Poly(propylene carbonate)-Based Block Polymer Micelles for Ultrasound Contrast Enhancementʺ, ACS Applied Materials & Interfaces 10(31), 26084-26098, 2018 (DOI: 10.1021/acsami.8b09630).

 

21)      H. C. Kim, D. Q. Arick, Y.-Y. Won, ʺAir-Water Interfacial Properties of Chloroform-Spread versus Water-Spread Poly((D,L-lactic acid-co-glycolic acid)-block-ethylene glycol) (PLGA-PEG) Polymersʺ, Langmuir 34(16), 4874-4887, 2018 (DOI: 10.1021/acs.langmuir.8b00566).

 

22)      H. C. Kim, Y.-Y. Won, ʺClinical, Technological, and Economic Issues Associated with Developing New Lung Surfactant Therapeuticsʺ, Biotechnology Advances 36(4), 1185-1193, 2018 (DOI: 10.​1016/​j.​biotechadv.​2018.​03.​017).

 

23)      S. D. Jo, J. Lee, M. K. Joo, V. Pizzuti, N. J. Sherck, S. Choi, B. S. Lee, S. H. Yeom, S. Y. Kim, S. H. Kim, I. C. Kwon, Y.-Y. Won, ʺPEG-PLA-Coated and Uncoated Radio-Luminescent CaWO4 Micro- and Nanoparticles for Concomitant Radiation and UV-A/Radio-Enhancement Cancer Treatmentsʺ, ACS Biomaterials Science & Engineering 4(4), 1445-1462, 2018 (DOI: 10.1021/acsbiomaterials.8b00119).

 

24)      S. R. Clark, K. Y. Lee, H. Lee, J. Khetan, H. C. Kim, Y. H. Choi, K. W. Shin, Y.-Y. Won, ʺDetermining the Effects of PEI Adsorption on the Permeability of 1,2-Dipalmitoylphosphatidylcholine/Bis(monoacylglycero)phosphate Membranes under Osmotic Stressʺ, Acta Biomaterialia 65, 317-326, 2018 (DOI: 10.1016/j.actbio.2017.10.027).

 

25)      N. J. Sherck, Y.-Y. Won, ʺA Simulation Study on the Feasibility of Radiotherapy Dose Enhancement with Calcium Tungstate and Hafnium Oxide Nano- and Microparticlesʺ, Medical Physics 44(12), 6583-6588, 2017 (DOI: 10.1002/mp.12588). An earlier and longer version of this article (titled ʺA Simulation Study on the Feasibility of Radio Enhancement Therapy with Calcium Tungstate and Hafnium Oxide Nanoparticlesʺ) has been published in arXiv (http://arxiv.org/abs/1608.05302).

 

26)      S.-E. Kim, B.-R. Lee, H. Lee, S. D. Jo, H. Kim, Y.-Y. Won, J. Lee, ʺNear-Infrared Plasmonic Assemblies of Gold Nanoparticles with Multimodal Functions for Targeted Cancer Theragnosisʺ, Scientific Reports 7, 17327, 2017 (DOI:10.1038/s41598-017-17714-2).

 

27)      H. C. Kim, Y. H. Choi, W. Bu, M. Meron, B. Lin, Y.-Y. Won, ʺIncreased Humidity Can Soften Glassy Langmuir Polymer Films by Two Mechanisms: Plasticization of the Polymer Material, and Suppression of the Evaporation Cooling Effectʺ, Physical Chemistry Chemical Physics 19, 10663-10675, 2017 (DOI: 10.1039/C7CP00785J).

 

28)      S.-E. Kim, S. D. Jo, K. C. Kwon, Y.-Y. Won, J. Lee, ʺGenetic Assembly of Double-Layered Fluorescent Protein Nanoparticles for Cancer Targeting and Imagingʺ, Advanced Science 1600471, 2017 (DOI: 10.1002/advs.201600471).

 

29)      J. Lee, S. Choi, K. H. Kim, H. G. Heng, S. E. Torregrosa-Allen, B. S. Ramsey, B. D. Elzey, Y.-Y. Won, ʺNon-Toxic Formulations of Scintillation Nanocrystals for Use as X-Ray Computed Tomography (CT) Contrast Agentsʺ, Bioconjugate Chemistry 28(1), 171-182, 2017 (DOI: 10.1021/acs.bioconjchem.6b00451).

 

30)      N. J. Sherck, H. C. Kim, Y.-Y. Won, ʺElucidating a Unified Mechanistic Scheme for the DBU-Catalyzed Ring-Opening Polymerization of Lactide to Poly(lactic acid), PLAʺ, Macromolecules 49(13), 4699-4713, 2016 (DOI: 10.1021/acs.macromol.6b00621).

 

31)      S. D. Jo, S. H. Ku, Y.-Y. Won, S. H. Kim, I. C. Kwon, ʺTargeted Nanotheranostics for Future Personalized Medicine: Recent Progress in Cancer Therapyʺ, Theranostics 6(9), 1362-1377, 2016 (DOI: 10.7150/thno.15335).

 

32)      J. Lee, N. J. Rancilio, J. M. Poulson, Y.-Y. Won, ʺBlock Copolymer-Encapsulated CaWO4 Nanoparticles: Synthesis, Formulation, and Characterizationʺ, ACS Applied Materials & Interfaces 8(13), 8608-8619, 2016 (DOI: 10.1021/acsami.6b00727).

 

33)      H. C. Kim, H. Lee, J. Khetan, Y.-Y. Won, ʺSurface Mechanical and Rheological Behaviors of Biocompatible Poly((D,L-lactic acid-ran-glycolic acid)-block-ethylene glycol) (PLGA-PEG) and Poly((D,L-lactic acid-ran-glycolic acid-ran-ε-caprolactone)-block-ethylene glycol) (PLGACL-PEG) Block Copolymers at the Air-Water Interfaceʺ, Langmuir 31(51), 13821-13833, 2015 (DOI: 10.1021/acs.langmuir.5b03622).

 

34)      D. Q. Arick, Y. H. Choi, H. C. Kim, Y.-Y. Won, ʺEffects of Nanoparticles on the Mechanical Functioning of the Lungʺ, Advances in Colloid and Interface Science 225, 218-228, 2015 (DOI: 10.1016/j.cis.2015.10.002).

 

35)      H. Lee, J. Lee, J. Park, T. Kwon, S. Hong, Y.-Y. Won, ʺCO2-Producing Polymer Micellesʺ, Polymer Degradation and Stability 120, 149-157, 2015 (DOI: 10.1016/j.polymdegradstab.2015.07.002).

 

36)      H. C. Kim, H. Lee, H. J. Jung, Y. H. Choi, M. Meron, B. Lin, J. Bang, Y.-Y. Won, ʺHumidity-Dependent Compression-Induced Glass Transition of the Air-Water Interfacial Langmuir Films of Poly(D,L-lactic acid-ran-glycolic acid) (PLGA)ʺ, Soft Matter 11, 5666-5677, 2015 (DOI: 10.1039/C4SM02535K).

 

37)      H. Kim, J. Lee, Y.-Y. Won, ʺA Simple Derivation of the Critical Condition for the Ultrasonic Atomization of Polymer Solutionsʺ Ultrasonics 61, 20-24, 2015 (DOI: 10.1016/j.ultras.2015.04.007).

 

38)      V. Tsouris, M. K. Joo, S. H. Kim, I. C. Kwon, Y.-Y. Won, ʺNano Carriers That Enable Co-Delivery of Chemotherapy and RNAi Agents for Treatment of Drug-Resistant Cancersʺ, Biotechnology Advances 32(5), 1037-1050, 2014 (DOI: 10.1016/j.biotechadv.2014.05.006).

 

39)      H. Lee, V. Tsouris, Y. Lim, R. Mustafa, J. Choi, Y. H. Choi, H.-W. Park, M. Meron, B. Lin, Y.-Y. Won, ʺMacroscopic Lateral Heterogeneity Observed in a Laterally-Mobile Immiscible Mixed Polyelectrolyte/Neutral Polymer Brushʺ, Soft Matter 10, 3771-3782, 2014 (DOI: 10.1039/C4SM00022F).

 

40)      H. Lee, Y. Kim, P. G. Schweickert, S. F. Konieczny, Y.-Y. Won, ʺA Photo-Degradable Gene Delivery System for Enhanced Nuclear Gene Transcriptionʺ, Biomaterials 35(3), 1040-1049, 2014 (DOI:10.1016/j.biomaterials.2013.10.030).

 

41)      Y.-Y. Won, H. Lee, ʺʺpH Phoresisʺ: A New Concept That Can Be Used for Improving Drug Delivery to Cancer Cellsʺ, Journal of Controlled Release 170(3), 396-400, 2013 (DOI: 10.1016/j.jconrel.2013.06.016). See ʺNanoparticles, ʹpH phoresisʹ could improve cancer drug deliveryʺ in Purdue News (July 8, 2013).

 

42)      D. J. Gary, J. Min, Y. Kim, K. Park, Y.-Y. Won, ʺThe Effect of N/P Ratio on the In Vitro and In Vivo Interaction Properties of PEGylated Poly(2-(dimethylamino)ethyl methacrylate)-Based siRNA Complexesʺ, Macromolecular Bioscience 13(8), 1059-1071, 2013 (DOI: 10.1002/mabi.201300046).

 

43)      H. W. Park, J. Choi, K. Ohn, H. Lee, J. W. Kim, Y.-Y. Won, ʺStudy of the Air-Water Interfacial Properties of Biodegradable Polyesters and Their Block Copolymers with Poly(ethylene glycol)ʺ, Langmuir 28(31), 11555-11566, 2012 (DOI: 10.1021/la300810q).

 

44)      H. Lee, D. H. Kim, K. N. Witte, K. Ohn, J. Choi, B. Akgun, S. Satija, Y.-Y. Won, ʺWater is a Poor Solvent for Densely Grafted Poly(ethylene oxide) Chains: A Conclusion Drawn from a Self-Consistent Field Theory-Based Analysis of Neutron Reflectivity and Surface Pressure-Area Isotherm Dataʺ, Journal of Physical Chemistry B 116(24), 7367-7378, 2012 (DOI: 10.1021/jp301817e).

 

45)      H. Lee, D. H. Kim, H.-W. Park, N. A. Mahynski, K. Kim, M. Meron, B. Lin, Y.-Y. Won, ʺReduced Water Density in a Poly(ethylene oxide) Brushʺ, Journal of Physical Chemistry Letters 3, 1589-1595, 2012 (DOI: 10.1021/jz3002772).

 

46)      D. H. Kim, A. Wei, Y.-Y. Won, ʺPreparation of Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micellesʺ, ACS Applied Materials & Interfaces 4(4), 1872-1877, 2012 (DOI: 10.1021/am300198v).

 

47)      R. Nap, Y.-Y. Won, I. Szleifer, ʺConfinement Induced Lateral Segregation of Polymer Coated Nanospheresʺ, Soft Matter 8(5), 1688-1700, 2012 (DOI: 10.1039/c2sm06549e).

 

48)      D. H. Kim, Y.-Y. Won, ʺIn Situ-Polymerized Carbon Nanotube/Polyimide Nanocomposites: Effect of Reaction Stoichiometry on the Glass Transition Properties of the Nanocompositesʺ, Macromolecular Reaction Engineering 6(1), 45-56, 2012 (DOI: 10.1002/mren.201100027). This article has been highlighted on the front cover of the journal.

 

49)      D. J. Gary, H. Lee, R. Sharma, J.-S. Lee, Y. Kim, Z. Y. Cui, D. Jia, V. D. Bowman, P. R. Chipman, L. Wan, Y. Zou, G. Mao, K. Park, B.-S. Herbert, S. F. Konieczny, Y.-Y. Won, ʺInfluence of Nano-Carrier Architecture on In Vitro siRNA Delivery Performance and In Vivo Biodistribution: Polyplexes vs. Micelleplexesʺ, ACS Nano 5(5), 3493-3505, 2011 (DOI: 10.1021/nn102540y).

 

50)      H. Lee, S. H. Son, R. Sharma, Y.-Y. Won, ʺA Discussion of the pH-Dependent Protonation Behaviors of Poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) and Poly(ethylenimine-ran-2-ethyl-2-oxazoline) (P(EI-r-EOz))ʺ, Journal of Physical Chemistry B 115(5), 844-860, 2011 (DOI: 10.1021/jp109151s).

 

51)      U. S. Kestur, H. Lee, D. Santiago, C. Rinaldi, Y.-Y. Won, L. S. Taylor, ʺEffects of the Molecular Weight and Concentration of Polymer Additives, and Temperature on the Melt Crystallization Kinetics of a Small Drug Moleculeʺ, Crystal Growth & Design 10(8), 3585-3595, 2010 (DOI: 10.1021/cg1004853).

 

52)      J. Hur, N. A. Mahynski, Y.-Y. Won, ʺCrystallization of Bidisperse Repulsive Colloids in Two-Dimensional Space: A Study of Model Systems Constructed at the Air-Water Interfaceʺ, Langmuir 26(14), 11737-11749, 2010 (DOI: 10.1021/la101313r).

 

53)      K. N. Witte, S. Kewalramani, I. Kuzmenko, W. Sun, M. Fukuto, Y.-Y. Won, ʺFormation and Collapse of Single-Monomer-Thick Monolayers of Poly(n-Butyl Acrylate) at the Air-Water Interfaceʺ, Macromolecules 43(6), 2990-3003, 2010 (DOI: 10.1021/ma901842q).

 

54)      J. Hur, K. N. Witte, W. Sun, Y.-Y. Won, ʺOn the Origins of the Salt-Concentration-Dependent Instability and Lateral Nanoscale Heterogeneities of Weak Polyelectrolyte Brushes: Gradient Brush Experiment, and Flory-Type Theoretical Analysisʺ, Langmuir 26(3), 2021-2034, 2010 (DOI: 10.1021/la902549b).

 

55)      Y.-Y. Won, R. Sharma, S. F. Konieczny, ʺMissing Pieces in Understanding the Intracellular Trafficking of Polycation/DNA Complexesʺ, Journal of Controlled Release 139(2), 88-93, 2009 (DOI: 10.1016/j.jconrel.2009.06.031). Erratum: Journal of Controlled Release 152(2), 326, 2009 (DOI: 10.1016/j.jconrel.2011.04.003).

 

56)      K. N. Witte, S. Kim, Y.-Y. Won, ʺSelf-Consistent Field Theory Study of the Effect of Grafting Density on the Height of a Weak Polyelectrolyte Brushʺ, Journal of Physical Chemistry B 113(32), 11076-11084, 2009 (DOI: 10.1021/jp809814j).

 

57)      K. N. Witte, J. Hur, W. Sun, S. Kim, Y.-Y. Won, ʺEvidence of Lateral Nanoscale Heterogeneities in Weak Polyelectrolyte Brushesʺ, Macromolecules 41(23), 8960-8963, 2008 (DOI: 10.1021/ma801412u).

 

58)      R. Sharma, J.-S. Lee, R. C. Bettencourt, C. Xiao, S. F. Konieczny, Y.-Y. Won, ʺEffects of the Incorporation of a Hydrophobic Middle Block into a PEG-Polycation Diblock Copolymer on the Physicochemical and Cell Interaction Properties of the Polymer-DNA Complexesʺ, Biomacromolecules 9(11), 3294-3307, 2008 (DOI: 10.1021/bm800876v).

 

59)      J. Hur, Y.-Y. Won, ʺFabrication of High-Quality Non-Close-Packed 2D Colloid Crystals by Template-Guided Langmuir-Blodgett (LB) Particle Depositionʺ, Soft Matter 4(6), 1261-1269, 2008 (DOI: 10.1039/b716218a). See ʺSelf-assembling Method Could Lead to Inexpensive Diamond-like Crystals for Technologyʺ in ScienceDaily (April 22, 2008). This article was one of the ten most downloaded Soft Matter articles for April 2010 (http://www.rsc.org/publishing/journals/sm/top10.asp)

 

60)      J. Hur, Y.-Y. Won, ʺTwo-Dimensional Colloid Crystals Templated by Polyelectrolyte Multilayer Patternsʺ, Langmuir 24(10), 5382-5392, 2008 (DOI: 10.1021/la704050t).

 

61)      K. N. Witte, Y.-Y. Won, ʺEffect of Interfacial Curvature on Mixed Polyelectrolyte and Neutral Polymer Brushes: An SCF Numerical Analysisʺ, Macromolecules 41(7), 2735-2738, 2008 (DOI: 10.1021/ma071682e).

 

62)      Y. Zhao, M. T. Carvajal, Y.-Y. Won, M. T. Harris, ʺPreparation of Calcium Alginate Microgel Beads by an Electrodispersion Reactor Using an Internal Source of Calcium Carbonate Nanoparticlesʺ, Langmuir 23(25), 12489-12496, 2007 (DOI: 10.1021/la701795y).

 

63)      D. Zhu, M. A. Haidekker, J.-S. Lee, Y.-Y. Won, J. C.-M. Lee, ʺApplication of Molecular Rotors to the Determination of the Molecular Weight-Dependence of Viscosity in Polymer Meltsʺ, Macromolecules 40(21), 7730-7732, 2007 (DOI: 10.1021/ma0702288).

 

64)      D. J. Gary, N. Puri, Y.-Y. Won, ʺPolymer-Based siRNA Delivery: Perspectives on the Fundamental and Phenomenological Distinctions from Polymer-Based DNA Deliveryʺ, Journal of Controlled Release 121(1-2), 64-73, 2007 (DOI: 10.1016/j.jconrel.2007.05.021).

 

65)      K. N. Witte, Y.-Y. Won, ʺSelf-Consistent Field (SCF) Analysis of Mixed Polyelectrolyte and Neutral Polymer Brushesʺ, Macromolecules 39(22), 7757-7768, 2006 (DOI: 10.1021/ma0608370).

 

66)      R. Sharma, A. Goyal, J. M. Caruthers, Y.-Y. Won, ʺInhibitive Chain Transfer to Ligand in the ATRP of n-Butyl Acrylateʺ, Macromolecules 39(14), 4680-4689, 2006 (DOI: 10.1021/ma060374y).

 

67)      Y.-Y. Won, S. P. Meeker, V. Trappe, D. A. Weitz, N. Z. Diggs, J. I. Emert, ʺEffect of Temperature on Carbon Black Agglomeration in Hydrocarbon Liquid with Adsorbed Dispersantʺ, Langmuir 21(4), 924-932, 2005 (DOI: 10.1021/la047906t).

 

68)      P. E. Trapa, Y.-Y. Won, S. C. Mui, E. A. Olivetti, B. Huang, D. R. Sadoway, A. M. Mayes, S. Dallek, ʺRubbery Graft Copolymer Electrolytes for Solid-State, Thin-Film Lithium Batteriesʺ, Journal of the Electrochemical Society 152(1), A1-A5, 2005 (DOI: 10.1149/1.1824032).

 

69)      Y.-Y. Won, ʺImaging Nanostructured Fluids Using Cryo-TEMʺ, Korean Journal of Chemical Engineering 21(1), 296-302, 2004 (DOI: 10.1007/BF02705412). This article has been referenced in an STTR call from the US Army, titled ʺNanoscale In-Solution TEM Sample Stage with Manipulation Capability (A08-T029)ʺ (January 22, 2008).

 

70)      Y.-Y. Won, H. T. Davis, F. S. Bates, ʺMolecular Exchange in PEO-PB Micelles in Waterʺ, Macromolecules 36(3), 953-955, 2003 (DOI: 10.1021/ma021439+).

 

71)      M. M. Santore, D. E. Discher, Y.-Y. Won, F. S. Bates, D. A. Hammer, ʺEffect of Surfactant on Unilamellar Polymeric Vesicles: Altered Membrane Properties and Stability in the Limit of Weak Surfactant Partitioningʺ, Langmuir 18(20), 7299-7308, 2002 (DOI: 10.1021/la0201319).

 

72)      J. F. Hester, P. Banergee, Y.-Y. Won, A. Akthakul, M. H. Acar, A. M. Mayes, ʺATRP of Amphiphilic Graft Copolymers Based on PVDF and Their Use as Membrane Additivesʺ, Macromolecules 35(20), 7652-7661, 2002 (DOI: 10.1021/ma0122270).

 

73)      P. E. Trapa, B. Huang, Y.-Y. Won, D. R. Sadoway, A. M. Mayes, ʺBlock Copolymer Electrolytes Synthesized by Atom Transfer Radical Polymerization for Solid-State, Thin-Film Lithium Batteriesʺ, Electrochemical and Solid-State Letters 5(5), A85-A88, 2002 (DOI: 10.1149/1.1461996).

 

74)      Y.-Y. Won, A. K. Brannan, H. T. Davis, F. S. Bates, ʺCryogenic Transmission Electron Microscopy (Cryo-TEM) of Micelles and Vesicles Formed in Water by Poly(ethylene oxide)-based Block Copolymersʺ, Journal of Physical Chemistry B 106(13), 3354-3364, 2002 (DOI: 10.1021/jp013639d).

 

75)      B. M. Discher, H. Bermudez, D. A. Hammer, D. E. Discher, Y.-Y. Won, F. S. Bates, ʺCrosslinked Polymersome Membranes: Vesicles with Broadly Adjustable Stabilityʺ, Journal of Physical Chemistry B 106(11), 2848-2854, 2002 (DOI: 10.1021/jp011958z).

 

76)      Y.-Y. Won, K. Paso, H. T. Davis, F. S. Bates, ʺComparison of Original and Cross-linked Wormlike Micelles of Poly(ethylene oxide-b-butadiene) in Water: Rheological Properties and Effects of Poly(ethylene oxide) Additionʺ, Journal of Physical Chemistry B 105(35), 8302-8311, 2001 (DOI: 10.1021/jp004078d).

 

77)      J. C.-M. Lee, H. Bermudez, B. M. Discher, M. Sheehan, Y.-Y. Won, F. S. Bates, D. E. Discher, ʺPreparation, Stability, and In Vitro Performance of Vesicles Made from Diblock Copolymersʺ, Biotechnology and Bioengineering 73(2), 135-145, 2001 (DOI: 10.1002/bit.1045).

 

78)      B. Jeong, M. R. Kibbey, J. C. Birnbaum, Y.-Y. Won, A. Gutowska, ʺThermogelling Biodegradable Polymers with Hydrophilic Backbones: PEG-g-PLGAʺ, Macromolecules 33(22), 8317-8322, 2000 (DOI: 10.1021/ma000638v).

 

79)      Y.-Y. Won, H. T. Davis, F. S. Bates, M. Agamalian, G. D. Wignall, ʺSegment Distribution of the Micellar Brushes of Poly(ethylene oxide) via Small-Angle Neutron Scatteringʺ, Journal of Physical Chemistry B 104(30), 7134-7143, 2000 (DOI: 10.1021/jp000457v). Addition/Correction: Journal of Physical Chemistry B 104(38), 9054-9054, 2000 (DOI: 10.1021/jp002934f).

 

80)      Y. Zheng, Y.-Y. Won, F. S. Bates, H. T. Davis, L. E. Scriven, Y. Talmon, ʺDirectly Resolved Core-Corona Structure of Block Copolymer Micelles by Cryo-Transmission Electron Microscopyʺ, Journal of Physical Chemistry B 103(47), 10331-10334, 1999 (DOI: 10.1021/jp9923264).

 

81)      B. M. Discher, Y.-Y. Won, J. C.-M. Lee, J. Eggs, F. S. Bates, D. E. Discher, D. A. Hammer, ʺPolymersomes: Vesicles Made from Diblock Copolymersʺ, Science 284 (5417), 1143-1146, 1999 (DOI: 10.1126/science.284.5417.1143).

 

82)      Y.-Y. Won, H. T. Davis, F. S. Bates, ʺGiant Wormlike Rubber Micellesʺ, Science 283 (5404), 960-963, 1999 (DOI: 10.1126/science.283.5404.960).

 

 

BOOK CHAPTERS

 

83)      Y.-Y. Won, F. S. Bates, ʺNonionic Block Copolymer Wormlike Micellesʺ, in Giant Micelles: Properties and Applications (Editors: R. Zana, E. W. Kaler), CRC Press/Taylor & Francis, Boca Raton, FL, 2007.

 

 

PUBLISHED PATENTS

 

84)      (a) ʺRadioluminescent Nanoparticles for Radiation-Triggered Controlled Release Drugsʺ Y.-Y. Won, R. Misra, J. Lee, pending U.S. Provisional Patent, Application No. 62/556,289, PRF Reference No. 68028-01, filed on September 8, 2017. (b) ʺRadioluminescent Nanoparticles for Radiation-Triggered Controlled Release Drugsʺ Y.-Y. Won, R. Misra, J. Lee, K. Sarkar, V. J. Pizzuti, pending PCT/U.S. Patent, Application No. 18/49823, PRF Reference No. 68028-02, filed on September 7, 2018.

 

85)      (a) ʺPolymer Lung Surfactantsʺ Y.-Y. Won, H. C. Kim, pending U.S. Provisional Patent, Application No. 62/374,325, PRF Reference No. 67605-01, filed on August 12, 2016. (b) ʺPolymer Lung Surfactantsʺ Y.-Y. Won, H. C. Kim, pending PCT/U.S. Patent, Application No. 17/46426, PRF Reference No. 67605-02, filed on August 11, 2017. (c) ʺPolymer Lung Surfactantsʺ Y.-Y. Won, H. C. Kim, pending U.S. Continuation-in-Part Patent, Application No. 15881723, PRF Reference No. 67605-03, filed on January 26, 2018.

 

86)      (a) ʺRadio-Luminescent Particles for Enhancement of Radiation Cancer Therapyʺ, Y.-Y. Won, M. K. Joo, B. S. Lee, S. Y. Kim, pending U.S. Provisional Patent, Application No. 62/101,275, PRF Reference No. 78695.P1.US, filed on January 8, 2015. (b) ʺRadio-Luminescent Particles for Enhancement of Radiation Cancer Therapyʺ, Y.-Y. Won, J. Lee, S. D. Jo, M. K. Joo, B. S. Lee, S. Y. Kim, S. H. Kim, pending PCT/U.S. Patent, Application No. 16/12616, PRF Reference No. 67028-03, filed on January 8, 2016. (c) ʺNon-Toxic Formulations of Radio-Luminescent Nanoparticles for Use as Cancer Radio-Sensitizing Agentsʺ Y.-Y. Won, J. Lee, pending PCT/U.S. Patent, Application No. 16/12684, PRF Reference No. 67028-02, filed on January 8, 2016. (d) ʺNon-Toxic Formulations of Radio-Luminescent Nanoparticles for Use as Cancer Radio-Sensitizing Agentsʺ Y.-Y. Won, J. Lee, nationalized in the U.S. on July 8, 2017 (PRF Reference No. 67028-04). (e) ʺNon-Toxic Formulations of Radio-Luminescent Nanoparticles for Use as Cancer Radio-Sensitizing Agentsʺ Y.-Y. Won, J. Lee, nationalized in the E.U. on August 8, 2017 (PRF Reference No. 67028-05).

 

87)      (a) ʺPoly(alkylene carbonate)-Based Amphiphilic Block Copolymers and Methods of Use Thereofʺ, Y.-Y. Won, H. Lee, J. Lee, J. Park, S. Hong, pending U.S. Provisional Patent, Application No. 62/078,738, PRF Reference No. 78595.P1.US, filed on November 12, 2014. (b) ʺPoly(alkylene carbonate)-Based Amphiphilic Block Copolymers and Methods of Use Thereofʺ, Y.-Y. Won, H. Lee, J. Lee, J. Park, S. Hong, pending PCT/U.S. Patent, Application No. 15/60430, PRF Reference No. 66901-02, filed on November 12, 2015. (c) ʺPoly(alkylene carbonate)-Based Amphiphilic Block Copolymers and Methods of Use Thereofʺ, Y.-Y. Won, H. Lee, J. Lee, J. Park, S. Hong, nationalized in the U.S. on May 12, 2017 (PRF Reference No. 66901-03).

 

88)      (a) ʺPreparation of Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micellesʺ, Y.-Y. Won, D. H. Kim, pending U.S. Provisional Patent, Application No. 61/619,548, PRF Reference No. 66166.P1.US, filed on April 3, 2012. (b) ʺBlock Copolymer (BCP) Encapsulated Nanoparticles and Methods of Use Thereofʺ, Y.-Y. Won, D. H. Kim, R. P. Andres, pending U.S. Patent, Application No. 13/837,705, PRF Reference No. 66166-02, filed on March 15, 2013, granted on October 10, 2017.

 

89)      ʺCross-linked Polymersomes and Related Encapsulating Membranesʺ, D. E. Discher, B. M. Discher, Y.-Y. Won, J. C.-M. Lee, F. S. Bates, D. A. Hammer, U.S. Patent No. 7,867,512, filed on February 20, 2007, granted on January 11, 2011.

 

90)      ʺPolymersomes and Related Encapsulating Membranesʺ, D. E. Discher, B. M. Discher, Y.-Y. Won, J. C.-M. Lee, F. S. Bates, D. A. Hammer, U.S. Patent No. 7,217,427 B2, filed on July 1, 2004, granted on May 15, 2007.

 

91)      ʺPolymersomes and Related Encapsulating Membranesʺ, D. E. Discher, B. M. Discher, Y.-Y. Won, J. C.-M. Lee, F. S. Bates, D. A. Hammer, U.S. Patent No. 6,835,394, filed December 14, 1999, granted on December 28, 2004.