Our laboratory
studies problems fundamental to developing new ways (nanotechnologies) to treat
cancer and respiratory diseases. Areas of focus include: (1) development of nanoparticle
therapeutics (radio-sensitizers and pulmonary surfactants) and polymer-based
drug/gene delivery systems, (2) investigations on interfacial phenomena of
polymers (with emphasis on Langmuir monolayers of polymers, block copolymer
micelles, and polymer/polyelectrolyte brushes), (3) understanding of the
complex behavior of charged polymers (“polyelectrolytes”), and (4) fabrication
of complex functional structures by self-assembly of block copolymers and
colloids. Links to individual publications are available at the Google Scholar
page
(https://scholar.google.com/citations?hl=en&user=xrm0ATF9pvUC&view_op=list_works&sortby=pubdate).
1)
A. P. Patel, C. R. Schorr, N. J. Streb, V. J. Pizzuti,
D. Viswanath, K. Sarkar, R. Misra, J. Lee, Y.-Y. Won, “Pilot-Scale Optimization of the Solvent Exchange
Production and Lyophilization Processing of PEG-PLA Block
Copolymer-Encapsulated CaWO4 Radioluminescent Nanoparticles for
Theranostic Applications”, submitted, 2020.
2)
H. Wee, Y.-Y. Won, “Brownian Diffusion of Colloidal Microspheres at
Polymer Micelle-Laden Air-Water Interfaces: Evidence for a Transition from a
Capillary Curvature Effect-Dominant to a Marangoni Stress Effect-Dominant
Regime at Dilute Micelle Surface Concentrations”, submitted, 2020.
3)
Y.-Y. Won, D. Ramkrishna, “Addition to “Revised
Formulation of Fick’s, Fourier’s, and Newton’s Laws for Spatially Varying
Linear Transport Coefficients””, ACS
Omega 5(51), 33484-33487, 2020 (DOI: 10.1021/acsomega.0c02856).
4)
J. Yoo, Y.-Y. Won, “Phenomenology of the Initial Burst
Release of Drugs from PLGA Microparticles”, ACS
Biomaterials Science & Engineering 6(11), 6053-6062, 2020 (DOI: 10.1021/acsbiomaterials.0c01228).
5)
D. W.
Kim, G. A. Medvedev, J. M. Caruthers, J. Y. Jo, Y.-Y. Won, J. Kim, “Enhancement of Mechano-Sensitivity for
Spiropyran-Linked Poly(dimethylsiloxane) via Solvent Swelling”, Macromolecules 53(18), 7954-7961, 2020
(DOI: 10.1021/acs.macromol.0c00985).
6)
V. J. Pizzuti, D.
Viswanath, S. E.
Torregrosa-Allen, M. P. Currie, B. D. Elzey, Y.-Y. Won, “Bilirubin-Coated Radio-Luminescent Particles for
Radiation-Induced Photodynamic Therapy”, ACS
Applied Bio Materials 3(8), 4858-4872, 2020 (DOI: 10.1021/acsabm.0c00354).
7)
J. Lee, J. Pan, J. Chun, Y.-Y. Won, “Unexpected
Conformational Behavior of Poly(poly(ethylene
glycol) methacrylate)-Poly(propylene carbonate)-Poly(poly(ethylene glycol)
methacrylate) (PPEGMA-PPC-PPEGMA) Amphiphilic Block Copolymers in Micellar
Solution and at the Air-Water Interface”,
Journal of Colloid and Interface Science 566, 304-315, 2020 (DOI: 10.1016/j.jcis.2020.01.080). Corrigendum: Journal
of Colloid and Interface Science 586, 596, 2021 (DOI: 10.1016/j.jcis.2020.10.126).
8)
V. J. Pizzuti, R. Misra, J. Lee, S. E. Torregrosa-Allen, M. P. Currie, S. R. Clark, A. P. Patel, C. R. Schorr,
Y. Jones-Hall, M. O. Childress, J. M. Plantenga, N. J. Rancilio, B. D. Elzey, Y.-Y. Won, “Folic
Acid-Conjugated Radioluminescent Calcium Tungstate Nanoparticles as Radio-Sensitizers for Cancer Radiotherapy”, ACS Biomaterials Science & Engineering
5(9), 4776-4789, 2019 (DOI: 10.1021/acsbiomaterials.9b00773).
9)
Y.-Y. Won, D. Ramkrishna, “Revised Formulation of
Fick’s, Fourier’s, and Newton’s Laws for Spatially Varying Linear Transport
Coefficients”, ACS Omega 4(6),
11215-11222, 2019 (DOI: 10.1021/acsomega.9b00736).
10)
R. Misra, K. Sarkar, J. Lee, V. J. Pizzuti, D. S. Lee,
M. P. Currie, S. E. Torregrosa-Allen, D. E. Long, G. A. Durm, M. P. Langer, B.
D. Elzey, Y.-Y. Won, “Radioluminescent Nanoparticles for Radiation-Controlled
Release of Drugs”, Journal of Controlled
Release 303, 237-252, 2019 (DOI: 10.1016/j.jconrel.2019.04.033).
11)
B. Chun, J. S. Park, H. W. Jung, Y.-Y. Won,
“Shear-Induced Particle Migration and Segregation in Non-Brownian Bidisperse
Suspensions under Planar Poiseuille Flow”, Journal
of Rheology 63(3), 437-453, 2019 (DOI: 10.1122/1.5065406).
12)
H. C. Kim, M. V. Suresh, V. V. Singh, D. Q. Arick, D. A.
Machado-Aranda, K. Raghavendran, Y.-Y. Won, “Polymer Lung
Surfactants”, ACS Applied Bio Materials
1(3), 581-592, 2018 (DOI: 10.1021/acsabm.8b00061).
13)
J. Lee, S. D.
Jo, H. Chung, W. Um, R. Chandrasekar, Y. H. Choi, V. M. Shalaev, Y.-Y. Won, “Laser-Induced CO2 Generation from Gold
Nanorod-Containing Poly(propylene carbonate)-Based Block Polymer Micelles for
Ultrasound Contrast Enhancement”, ACS Applied
Materials & Interfaces 10(31),
26084-26098, 2018
(DOI: 10.1021/acsami.8b09630).
14)
H. C. Kim, D. Q. Arick, Y.-Y. Won, “Air-Water
Interfacial Properties of Chloroform-Spread versus Water-Spread
Poly((D,L-lactic acid-co-glycolic
acid)-block-ethylene glycol)
(PLGA-PEG) Polymers”, Langmuir 34(16),
4874-4887, 2018 (DOI: 10.1021/acs.langmuir.8b00566).
15)
H. C. Kim, Y.-Y. Won, “Clinical, Technological, and Economic Issues
Associated with Developing New Lung Surfactant Therapeutics”, Biotechnology Advances 36(4), 1185-1193,
2018 (DOI: 10.1016/j.biotechadv.2018.03.017).
16)
S. D. Jo, J. Lee, M. K. Joo, V. Pizzuti, N. J. Sherck,
S. Choi, B. S. Lee, S. H. Yeom, S. Y. Kim, S. H. Kim, I. C. Kwon, Y.-Y. Won,
“PEG-PLA-Coated and Uncoated Radio-Luminescent CaWO4 Micro- and
Nanoparticles for Concomitant Radiation and UV-A/Radio-Enhancement Cancer
Treatments”, ACS Biomaterials Science
& Engineering 4(4), 1445-1462, 2018 (DOI: 10.1021/acsbiomaterials.8b00119).
17)
S. R. Clark, K. Y. Lee, H. Lee, J. Khetan, H. C. Kim,
Y. H. Choi, K. W. Shin, Y.-Y. Won, “Determining the Effects of PEI Adsorption
on the Permeability of
1,2-Dipalmitoylphosphatidylcholine/Bis(monoacylglycero)phosphate Membranes
under Osmotic Stress”, Acta Biomaterialia
65, 317-326, 2018 (DOI: 10.1016/j.actbio.2017.10.027).
18)
N. J. Sherck, Y.-Y. Won, “A Simulation Study on the
Feasibility of Radiotherapy Dose Enhancement with Calcium Tungstate and Hafnium
Oxide Nano- and Microparticles”, Medical
Physics 44(12), 6583-6588, 2017 (DOI:
10.1002/mp.12588). An
earlier and longer version of this article (titled “A Simulation Study on the Feasibility
of Radio Enhancement Therapy with Calcium Tungstate and Hafnium Oxide
Nanoparticles”) has been published in arXiv (http://arxiv.org/abs/1608.05302).
19)
S.-E.
Kim, B.-R. Lee, H. Lee, S. D. Jo, H. Kim, Y.-Y. Won, J. Lee, “Near-Infrared
Plasmonic Assemblies of Gold Nanoparticles with Multimodal Functions for
Targeted Cancer Theragnosis”, Scientific
Reports 7, 17327, 2017 (DOI:10.1038/s41598-017-17714-2).
20)
H. C. Kim, Y. H. Choi, W. Bu, M. Meron, B. Lin, Y.-Y.
Won, “Increased Humidity Can Soften Glassy Langmuir Polymer Films by Two
Mechanisms: Plasticization of the Polymer Material, and Suppression of the
Evaporation Cooling Effect”, Physical
Chemistry Chemical Physics 19, 10663-10675, 2017 (DOI: 10.1039/C7CP00785J).
21)
S.-E. Kim, S. D. Jo, K. C. Kwon, Y.-Y. Won, J. Lee, “Genetic
Assembly of Double-Layered Fluorescent Protein Nanoparticles for Cancer
Targeting and Imaging”, Advanced
Science 1600471, 2017 (DOI: ).
22)
J. Lee,
S. Choi, K. H. Kim, H. G. Heng, S. E. Torregrosa-Allen, B. S. Ramsey, B. D.
Elzey, Y.-Y. Won, “Non-Toxic Formulations of Scintillation Nanocrystals for Use
as X-Ray Computed Tomography (CT) Contrast Agents”, Bioconjugate Chemistry 28(1), 171-182, 2017 (DOI:
10.1021/acs.bioconjchem.6b00451).
23)
N. J. Sherck, H. C. Kim, Y.-Y. Won, “Elucidating a
Unified Mechanistic Scheme for the DBU-Catalyzed Ring-Opening Polymerization of
Lactide to Poly(lactic acid), PLA”, Macromolecules
49(13), 4699-4713, 2016 (DOI: 10.1021/acs.macromol.6b00621).
24)
S. D. Jo,
S. H. Ku, Y.-Y. Won, S. H. Kim, I. C. Kwon, “Targeted Nanotheranostics for Future Personalized Medicine: Recent Progress in Cancer
Therapy”, Theranostics 6(9),
1362-1377, 2016 (DOI: 10.7150/thno.15335).
25)
J. Lee, N. J. Rancilio, J. M. Poulson, Y.-Y. Won,
“Block Copolymer-Encapsulated CaWO4 Nanoparticles: Synthesis,
Formulation, and Characterization”, ACS
Applied Materials & Interfaces 8(13), 8608–8619, 2016 (DOI: 10.1021/acsami.6b00727).
26)
H. C. Kim, H. Lee, J. Khetan, Y.-Y. Won, “Surface
Mechanical and Rheological Behaviors of Biocompatible Poly((D,L-lactic acid-ran-glycolic acid)-block-ethylene glycol) (PLGA-PEG) and Poly((D,L-lactic acid-ran-glycolic acid-ran-ε-caprolactone)-block-ethylene
glycol) (PLGACL-PEG) Block Copolymers at the Air-Water Interface”, Langmuir 31(51), 13821-13833, 2015 (DOI:
10.1021/acs.langmuir.5b03622).
27)
D. Q. Arick, Y. H. Choi, H. C. Kim, Y.-Y. Won,
“Effects of Nanoparticles on the Mechanical Functioning of the Lung”, Advances in Colloid and Interface Science
225, 218-228, 2015 (DOI: 10.1016/j.cis.2015.10.002).
28)
H. Lee, J. Lee, J. Park, T. Kwon, S. Hong, Y.-Y. Won,
“CO2-Producing Polymer Micelles”, Polymer Degradation and Stability 120, 149-157, 2015 (DOI:
10.1016/j.polymdegradstab.2015.07.002).
29)
H. C. Kim, H. Lee, H. J. Jung, Y. H. Choi, M. Meron,
B. Lin, J. Bang, Y.-Y. Won, “Humidity-Dependent Compression-Induced Glass
Transition of the Air-Water Interfacial Langmuir Films of Poly(D,L-lactic acid-ran-glycolic acid) (PLGA)”, Soft Matter 11, 5666-5677, 2015 (DOI:
10.1039/C4SM02535K).
30)
H. Kim, J. Lee, Y.-Y. Won, “A Simple Derivation of the
Critical Condition for the Ultrasonic Atomization of Polymer Solutions” Ultrasonics 61, 20-24, 2015 (DOI: 10.1016/j.ultras.2015.04.007).
31)
V. Tsouris, M. K. Joo, S. H. Kim, I. C. Kwon, Y.-Y.
Won, “Nano Carriers That Enable Co-Delivery of Chemotherapy and RNAi Agents for
Treatment of Drug-Resistant Cancers”, Biotechnology
Advances 32(5), 1037-1050, 2014 (DOI:
32)
H. Lee, V. Tsouris, Y. Lim, R. Mustafa, J. Choi, Y. H.
Choi, H.-W. Park, M. Meron, B. Lin, Y.-Y. Won, “Macroscopic Lateral
Heterogeneity Observed in a Laterally-Mobile Immiscible Mixed
Polyelectrolyte/Neutral Polymer Brush”, Soft
Matter 10, 3771-3782, 2014 (DOI: 10.1039/C4SM00022F).
33)
H. Lee, Y. Kim, P. G. Schweickert, S. F. Konieczny,
Y.-Y. Won, “A Photo-Degradable Gene Delivery System for Enhanced Nuclear Gene
Transcription”, Biomaterials 35(3),
1040-1049, 2014 (DOI:
34)
Y.-Y. Won, H. Lee, ““pH Phoresis”: A New Concept That
Can Be Used for Improving Drug Delivery to Cancer Cells”, Journal of Controlled Release 170(3), 396-400, 2013 (DOI:
10.1016/j.jconrel.2013.06.016). See "Nanoparticles, 'pH phoresis' could
improve cancer drug delivery" in Purdue News (July 8, 2013).
35)
D. J. Gary, J. Min, Y. Kim, K. Park, Y.-Y. Won, “The
Effect of N/P Ratio on the In Vitro
and In Vivo Interaction Properties of
PEGylated Poly(2-(dimethylamino)ethyl methacrylate)-Based siRNA Complexes”, Macromolecular
Bioscience 13(8), 1059-1071, 2013 (DOI: 10.1002/mabi.201300046).
36)
H. W. Park, J. Choi, K. Ohn, H. Lee, J. W. Kim, Y.-Y.
Won, “Study of the Air-Water Interfacial Properties of Biodegradable Polyesters
and Their Block Copolymers with Poly(ethylene glycol)”, Langmuir 28(31), 11555-11566, 2012 (DOI: 10.1021/la300810q).
37)
H. Lee, D. H. Kim, K. N. Witte, K. Ohn, J. Choi, B.
Akgun, S. Satija, Y.-Y. Won, “Water
is a Poor Solvent for Densely Grafted Poly(ethylene oxide) Chains: A Conclusion
Drawn from a Self-Consistent Field Theory-Based Analysis of Neutron
Reflectivity and Surface Pressure-Area Isotherm Data”, Journal of Physical Chemistry B 116(24), 7367-7378, 2012 (DOI:
10.1021/jp301817e).
38)
H. Lee, D. H. Kim, H.-W. Park, N. A. Mahynski, K. Kim,
M. Meron, B. Lin, Y.-Y. Won, “Reduced Water Density in a Poly(ethylene oxide)
Brush”, Journal of Physical Chemistry
Letters 3, 1589-1595, 2012 (DOI:
10.1021/jz3002772).
39)
D. H. Kim, A. Wei, Y.-Y. Won, “Preparation of
Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micelles”, ACS Applied Materials & Interfaces 4(4), 1872-1877, 2012 (DOI: 10.1021/am300198v).
40)
R. Nap, Y.-Y. Won, I. Szleifer, “Confinement Induced
Lateral Segregation of Polymer Coated Nanospheres”, Soft Matter 8(5), 1688-1700, 2012 (DOI: 10.1039/c2sm06549e).
41)
D. H. Kim, Y.-Y. Won, “In Situ-Polymerized Carbon
Nanotube/Polyimide Nanocomposites: Effect of Reaction Stoichiometry on the
Glass Transition Properties of the Nanocomposites”, Macromolecular Reaction Engineering 6(1), 45-56, 2012 (DOI:
10.1002/mren.201100027). This article has been highlighted on the front
cover of the journal.
42)
D. J. Gary, H. Lee, R. Sharma, J.-S. Lee, Y. Kim, Z.
Y. Cui, D. Jia, V. D. Bowman, P. R. Chipman, L. Wan, Y. Zou, G. Mao, K. Park,
B.-S. Herbert, S. F. Konieczny, Y.-Y. Won, “Influence of Nano-Carrier
Architecture on In Vitro siRNA Delivery Performance and In Vivo
Biodistribution: Polyplexes vs. Micelleplexes”, ACS Nano 5(5), 3493-3505, 2011 (DOI: 10.1021/nn102540y).
43)
H. Lee, S. H. Son, R. Sharma, Y.-Y. Won, “A Discussion
of the pH-Dependent Protonation Behaviors of Poly(2-(dimethylamino)ethyl
methacrylate) (PDMAEMA) and Poly(ethylenimine-ran-2-ethyl-2-oxazoline) (P(EI-r-EOz))”,
Journal of Physical Chemistry B 115(5),
844-860, 2011 (DOI: 10.1021/jp109151s).
44)
U. S. Kestur, H. Lee, D. Santiago, C. Rinaldi, Y.-Y.
Won, L. S. Taylor, “Effects of the Molecular Weight and Concentration of
Polymer Additives, and Temperature on the Melt Crystallization Kinetics of a
Small Drug Molecule”, Crystal Growth
& Design 10(8), 3585-3595, 2010 (DOI:
10.1021/cg1004853).
45)
J. Hur, N. A. Mahynski, Y.-Y. Won, “Crystallization of
Bidisperse Repulsive Colloids in Two-Dimensional Space: A Study of Model
Systems Constructed at the Air-Water Interface”, Langmuir 26(14), 11737-11749, 2010 (DOI:
10.1021/la101313r).
46)
K. N. Witte, S. Kewalramani, I. Kuzmenko, W. Sun, M. Fukuto,
Y.-Y. Won, “Formation and Collapse of Single-Monomer-Thick Monolayers of Poly(n-Butyl Acrylate) at the Air-Water
Interface”, Macromolecules 43(6),
2990-3003, 2010 (DOI: 10.1021/ma901842q).
47)
J. Hur, K. N. Witte, W. Sun, Y.-Y. Won, “On the
Origins of the Salt-Concentration-Dependent Instability and Lateral Nanoscale
Heterogeneities of Weak Polyelectrolyte Brushes: Gradient Brush Experiment, and
Flory-Type Theoretical Analysis”, Langmuir
26(3), 2021-2034, 2010 (DOI: 10.1021/la902549b).
48)
Y.-Y. Won, R. Sharma, S. F. Konieczny, “Missing Pieces
in Understanding the Intracellular Trafficking of Polycation/DNA Complexes”, Journal of Controlled Release 139(2),
88-93, 2009 (DOI: 10.1016/j.jconrel.2009.06.031). Erratum: Journal of Controlled Release 152(2),
326, 2009 (DOI: 10.1016/j.jconrel.2011.04.003).
49)
K. N. Witte, S. Kim, Y.-Y. Won, “Self-Consistent Field
Theory Study of the Effect of Grafting Density on the Height of a Weak
Polyelectrolyte Brush”, Journal of
Physical Chemistry B 113(32), 11076-11084, 2009 (DOI: 10.1021/jp809814j).
50)
K. N. Witte, J. Hur, W. Sun, S. Kim, Y.-Y. Won,
“Evidence of Lateral Nanoscale Heterogeneities in Weak Polyelectrolyte
Brushes”, Macromolecules 41(23),
8960-8963, 2008 (DOI: 10.1021/ma801412u).
51)
R. Sharma, J.-S. Lee, R. C. Bettencourt, C. Xiao, S.
F. Konieczny, Y.-Y. Won, “Effects of
the Incorporation of a Hydrophobic Middle Block into a PEG-Polycation Diblock
Copolymer on the Physicochemical and Cell Interaction Properties of the
Polymer-DNA Complexes”, Biomacromolecules
9(11), 3294-3307, 2008 (DOI: 10.1021/bm800876v).
52)
J. Hur, Y.-Y. Won, “Fabrication of High-Quality Non-Close-Packed 2D Colloid Crystals by
Template-Guided Langmuir-Blodgett (LB) Particle Deposition”, Soft Matter 4(6), 1261-1269, 2008 (DOI:
10.1039/b716218a). See "Self-assembling Method Could Lead to
Inexpensive Diamond-like Crystals for Technology" in
ScienceDaily (April 22, 2008). This article was one of the ten most downloaded
Soft Matter articles for April 2010 (http://www.rsc.org/publishing/journals/sm/top10.asp)
53)
J. Hur, Y.-Y. Won, “Two-Dimensional Colloid Crystals
Templated by Polyelectrolyte Multilayer Patterns”, Langmuir 24(10), 5382-5392, 2008
(DOI: 10.1021/la704050t).
54)
K. N. Witte, Y.-Y. Won,
“Effect of Interfacial Curvature on Mixed Polyelectrolyte and Neutral Polymer
Brushes: An SCF Numerical Analysis”, Macromolecules
41(7), 2735-2738, 2008 (DOI: 10.1021/ma071682e).
55)
Y. Zhao, M. T.
Carvajal, Y.-Y. Won, M. T. Harris, “Preparation of Calcium Alginate Microgel
Beads by an Electrodispersion Reactor Using an Internal Source of Calcium Carbonate
Nanoparticles”, Langmuir 23(25),
12489-12496, 2007 (DOI: 10.1021/la701795y).
56)
D. Zhu, M. A. Haidekker, J.-S. Lee, Y.-Y.
Won, J. C.-M. Lee, “Application of Molecular Rotors to the Determination of the
Molecular Weight-Dependence of Viscosity in Polymer Melts”, Macromolecules 40(21), 7730-7732, 2007 (DOI: 10.1021/ma0702288).
57)
D. J. Gary, N. Puri, Y.-Y. Won, “Polymer-Based siRNA
Delivery: Perspectives on the Fundamental and Phenomenological Distinctions
from Polymer-Based DNA Delivery”, Journal
of Controlled Release 121(1-2), 64-73, 2007 (DOI: 10.1016/j.jconrel.2007.05.021).
58)
K.
N. Witte, Y.-Y. Won, “Self-Consistent
Field (SCF) Analysis of Mixed Polyelectrolyte and Neutral Polymer Brushes”, Macromolecules
39(22), 7757-7768, 2006 (DOI:
10.1021/ma0608370).
59)
R. Sharma, A. Goyal, J. M. Caruthers, Y.-Y. Won, “Inhibitive Chain Transfer to Ligand
in the ATRP of n-Butyl Acrylate”, Macromolecules 39(14),
4680-4689, 2006 (DOI: 10.1021/ma060374y).
60)
Y.-Y. Won, S. P. Meeker, V. Trappe, D. A. Weitz, N. Z.
Diggs, J. I. Emert, “Effect of Temperature on Carbon Black Agglomeration in Hydrocarbon
Liquid with Adsorbed Dispersant”, Langmuir 21(4), 924-932, 2005 (DOI: 10.1021/la047906t).
61)
P. E. Trapa, Y.-Y. Won, S. C. Mui, E. A. Olivetti, B.
Huang, D. R. Sadoway, A. M. Mayes, S. Dallek, “Rubbery Graft
Copolymer Electrolytes for Solid-State, Thin-Film Lithium Batteries”, Journal of the Electrochemical Society
152(1), A1-A5, 2005 (DOI: 10.1149/1.1824032).
62)
Y.-Y. Won, “Imaging Nanostructured Fluids Using
Cryo-TEM”, Korean Journal of Chemical Engineering 21(1), 296-302, 2004
(DOI: 10.1007/BF02705412). This article has been referenced in an STTR
call from the US Army, titled “Nanoscale In-Solution TEM Sample Stage with
Manipulation Capability (A08-T029)” (January 22,
2008).
63)
Y.-Y. Won, H. T. Davis, F. S. Bates, “Molecular
Exchange in PEO-PB Micelles in Water”, Macromolecules 36(3), 953-955,
2003 (DOI: 10.1021/ma021439+).
64)
M. M. Santore, D. E. Discher, Y.-Y. Won, F. S. Bates,
D. A. Hammer, “Effect of Surfactant on Unilamellar Polymeric Vesicles: Altered
Membrane Properties and Stability in the Limit of Weak Surfactant
Partitioning”, Langmuir 18(20), 7299-7308, 2002 (DOI: 10.1021/la0201319).
65)
J. F. Hester, P. Banergee, Y.-Y. Won, A. Akthakul, M.
H. Acar, A. M. Mayes, “ATRP of Amphiphilic Graft Copolymers Based on PVDF and
Their Use as Membrane Additives”, Macromolecules 35(20), 7652-7661, 2002
(DOI: 10.1021/ma0122270).
66)
P. E. Trapa, B. Huang, Y.-Y. Won, D. R. Sadoway, A. M.
Mayes, “Block Copolymer Electrolytes Synthesized by Atom Transfer Radical
Polymerization for Solid-State, Thin-Film Lithium Batteries”, Electrochemical
and Solid-State Letters 5(5), A85-A88, 2002 (DOI: 10.1149/1.1461996).
67)
Y.-Y. Won, A. K. Brannan, H. T. Davis, F. S. Bates,
“Cryogenic Transmission Electron Microscopy (Cryo-TEM) of Micelles and Vesicles
Formed in Water by Poly(ethylene oxide)-based Block Copolymers”, Journal of
Physical Chemistry B 106(13), 3354-3364, 2002 (DOI: 10.1021/jp013639d).
68)
B. M. Discher, H. Bermudez, D. A. Hammer, D. E.
Discher, Y.-Y. Won, F. S. Bates, “Crosslinked Polymersome Membranes: Vesicles
with Broadly Adjustable Stability”, Journal of Physical Chemistry B
106(11), 2848-2854, 2002 (DOI: 10.1021/jp011958z).
69)
Y.-Y. Won, K. Paso, H. T. Davis, F. S. Bates,
“Comparison of Original and Cross-linked Wormlike Micelles of Poly(ethylene
oxide-b-butadiene) in Water: Rheological Properties and Effects of
Poly(ethylene oxide) Addition”, Journal of Physical Chemistry B 105(35),
8302-8311, 2001 (DOI: 10.1021/jp004078d).
70)
J. C.-M. Lee, H. Bermudez, B. M. Discher, M. Sheehan,
Y.-Y. Won, F. S. Bates, D. E. Discher, “Preparation, Stability, and In Vitro Performance of
Vesicles Made from Diblock Copolymers”, Biotechnology and Bioengineering
73(2), 135-145, 2001 (DOI: 10.1002/bit.1045).
71)
B. Jeong, M. R. Kibbey, J. C. Birnbaum, Y.-Y. Won, A.
Gutowska, “Thermogelling Biodegradable Polymers with Hydrophilic Backbones:
PEG-g-PLGA”, Macromolecules 33(22), 8317-8322, 2000 (DOI: 10.1021/ma000638v).
72)
Y.-Y. Won, H. T. Davis, F. S. Bates, M. Agamalian, G.
D. Wignall, “Segment Distribution of the Micellar Brushes of Poly(ethylene
oxide) via Small-Angle Neutron Scattering”, Journal of Physical Chemistry B
104(30), 7134-7143, 2000 (DOI: 10.1021/jp000457v). Addition/Correction:
Journal of Physical Chemistry B 104(38), 9054-9054, 2000 (DOI:
10.1021/jp002934f).
73)
Y. Zheng, Y.-Y. Won, F. S. Bates, H. T. Davis, L. E.
Scriven, Y. Talmon, “Directly Resolved Core-Corona Structure of Block Copolymer
Micelles by Cryo-Transmission Electron Microscopy”, Journal of Physical
Chemistry B 103(47), 10331-10334, 1999 (DOI: 10.1021/jp9923264).
74)
B. M. Discher, Y.-Y. Won, J. C.-M. Lee, J. Eggs, F. S.
Bates, D. E. Discher, D. A. Hammer, “Polymersomes: Vesicles Made from Diblock
Copolymers”, Science 284 (5417), 1143-1146, 1999 (DOI:
10.1126/science.284.5417.1143).
75)
Y.-Y. Won, H. T. Davis, F. S. Bates, “Giant Wormlike
Rubber Micelles”, Science 283 (5404), 960-963, 1999 (DOI:
10.1126/science.283.5404.960).
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Y.-Y.
Won, F. S. Bates, “Nonionic Block Copolymer Wormlike Micelles”, in Giant Micelles: Properties and Applications
(Editors: R. Zana, E. W. Kaler), CRC Press/Taylor & Francis, Boca Raton,
FL, 2007.
PUBLISHED PATENTS
77)
(a) “Radioluminescent Nanoparticles for
Radiation-Triggered Controlled Release Drugs” Y.-Y. Won, R. Misra, J. Lee,
pending U.S. Provisional Patent,
Application No. 62/556,289, PRF
Reference No. 68028-01, filed on
September 8, 2017. (b) “Radioluminescent Nanoparticles for
Radiation-Triggered Controlled Release Drugs” Y.-Y. Won, R. Misra, J. Lee, K.
Sarkar, V. J. Pizzuti, pending PCT/U.S.
Patent, Application No. 18/49823, PRF Reference No. 68028-02, filed on September 7, 2018.
78)
(a) “Polymer Lung Surfactants” Y.-Y. Won, H. C. Kim,
pending U.S. Provisional Patent,
Application No. 62/374,325, PRF
Reference No. 67605-01, filed on
August 12, 2016. (b) “Polymer Lung Surfactants” Y.-Y. Won, H. C. Kim, pending PCT/U.S.
Patent, Application No. 17/46426, PRF Reference No. 67605-02, filed on August 11, 2017. (c) “Polymer Lung
Surfactants” Y.-Y. Won, H. C. Kim, pending U.S. Continuation-in-Part Patent,
Application No. 15881723, PRF Reference No. 67605-03, filed on January 26, 2018.
79)
(a) “Radio-Luminescent Particles for Enhancement of
Radiation Cancer Therapy”, Y.-Y. Won, M. K. Joo, B. S. Lee, S. Y. Kim, pending U.S.
Provisional Patent, Application No. 62/101,275, PRF Reference No.
78695.P1.US, filed on January 8, 2015. (b) “Radio-Luminescent Particles for Enhancement of
Radiation Cancer Therapy”, Y.-Y. Won, J. Lee, S. D. Jo, M. K. Joo, B. S. Lee,
S. Y. Kim, S. H. Kim, pending
PCT/U.S. Patent, Application No.
16/12616, PRF Reference No. 67028-03, filed on January 8, 2016. (c) “Non-Toxic
Formulations of Radio-Luminescent Nanoparticles for Use as Cancer
Radio-Sensitizing Agents” Y.-Y. Won, J. Lee, pending PCT/U.S.
Patent, Application No. 16/12684, PRF Reference No. 67028-02, filed on
January 8, 2016. (d) “Non-Toxic Formulations of Radio-Luminescent
Nanoparticles for Use as Cancer Radio-Sensitizing Agents” Y.-Y. Won, J. Lee, nationalized in the U.S. on July 8, 2017 (PRF Reference
No. 67028-04). (e) “Non-Toxic Formulations of Radio-Luminescent
Nanoparticles for Use as Cancer Radio-Sensitizing Agents” Y.-Y. Won, J. Lee, nationalized in the E.U. on August 8, 2017 (PRF
Reference No. 67028-05).
80)
(a) “Poly(alkylene carbonate)-Based Amphiphilic Block
Copolymers and Methods of Use Thereof”, Y.-Y. Won, H. Lee, J. Lee, J. Park, S.
Hong, pending U.S. Provisional Patent, Application No.
62/078,738, PRF Reference No. 78595.P1.US, filed on November 12,
2014. (b) “Poly(alkylene
carbonate)-Based Amphiphilic Block Copolymers and Methods of Use Thereof”,
Y.-Y. Won, H. Lee, J. Lee, J. Park, S. Hong, pending PCT/U.S.
Patent, Application No. 15/60430, PRF Reference No. 66901-02, filed on
November 12, 2015. (c) “Poly(alkylene carbonate)-Based Amphiphilic Block
Copolymers and Methods of Use Thereof”, Y.-Y. Won, H. Lee, J. Lee, J. Park, S.
Hong, nationalized in
the U.S. on May 12, 2017 (PRF Reference No. 66901-03).
81)
(a) “Preparation of
Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micelles”, Y.-Y. Won, D. H. Kim, pending U.S. Provisional Patent, Application No. 61/619,548, PRF Reference
No. 66166.P1.US, filed on April 3, 2012. (b) “Block Copolymer (BCP) Encapsulated Nanoparticles and
Methods of Use Thereof”, Y.-Y. Won, D. H. Kim, R. P. Andres, pending U.S.
Patent, Application No.
13/837,705, PRF Reference No. 66166-02, filed on March 15, 2013, granted on
October 10, 2017.
82)
“Cross-linked Polymersomes and Related Encapsulating Membranes”,
D. E. Discher, B. M. Discher, Y.-Y. Won, J. C.-M. Lee, F. S. Bates, D. A.
Hammer, U.S. Patent No.
7,867,512, filed on February 20, 2007, granted on January 11, 2011.
83)
“Polymersomes and Related Encapsulating Membranes”, D.
E. Discher, B. M. Discher, Y.-Y. Won, J. C.-M. Lee, F. S. Bates, D. A. Hammer, U.S.
Patent No. 7,217,427 B2, filed on
July 1, 2004, granted on May 15, 2007.
84)
“Polymersomes and Related Encapsulating Membranes”, D.
E. Discher, B. M. Discher, Y.-Y. Won, J. C.-M. Lee, F. S. Bates, D. A. Hammer, U.S.
Patent No. 6,835,394, filed
December 14, 1999, granted on December 28, 2004.