Our laboratory
studies problems fundamental to developing new improved ways to treat cancer
and respiratory distress. Areas of focus include: (1) development of
nanoparticle therapeutics (immunogenic radiosensitizers and fully synthetic
pulmonary surfactants) and polymer-based controlled release drug/gene delivery
systems, (2) investigations on interfacial phenomena of polymers (with emphasis
on Langmuir monolayers of polymers, block copolymer micelles, and
polymer/polyelectrolyte brushes), (3) understanding of the complex behavior of
charged polymers (ʺpolyelectrolytesʺ), and (4) fabrication of complex
functional structures by self-assembly of block copolymers and colloids. Links
to individual publications are available at the Google Scholar page
(https://scholar.google.com/citations?hl=en&user=xrm0ATF9pvUC&view_op=list_works&sortby=pubdate).
1)
Daniel J. Fesenmeier, Madathilparambil V. Suresh, Seyoung
Kim, Krishnan Raghavendran, You-Yeon Won, ʺPolymer
Lung Surfactant Therapy Reduces Lung Injury and Inflammation in Mouse Models of
Direct Lung Injuryʺ,
submitted, 2022.
2)
Yun
Chang, Xuechao Cai, Ramizah
Syahirah, Yuxin Yao, Yang
Xu, Gyuhyung Jin, Vijesh J. Bhute, Sandra Torregrosa-Allen, Bennett D. Elzey,
You-Yeon Won, Qing Deng, Xiaoguang Wang, Omolola Eniola-Adefeso,
Xiaoping Bao, ʺBlood-Brain
Barrier-Penetrating CAR Neutrophil-Mediated Delivery of Tumor
Microenvironment-Responsive Nanodrugs for Effective and Safe Glioblastoma
Chemoimmunotherapyʺ,
submitted, 2022.
3)
Dhushyanth Viswanath, You-Yeon Won, ʺCombining Radiotherapy (RT) and Photodynamic Therapy
(PDT): Clinical Studies on Conventional RT-PDT Approaches, and Novel
Nanoparticle-Based RT-PDT Approaches under Preclinical Evaluationʺ, ACS Biomaterials Science & Engineering accepted/in
press, 2022 (DOI: 10.1021/acsbiomaterials.2c00287).
4)
Kaustabh Sarkar, Sandra E. Torregrosa-Allen,
Bennett D. Elzey, Sanjeev Narayanan, Mark P. Langer,
Gregory A. Durm, You-Yeon Won, ʺEffect of
Paclitaxel Stereochemistry on X-ray-Triggered Release of Paclitaxel from CaWO4/Paclitaxel-Coloaded
PEG-PLA Nanoparticlesʺ, Molecular
Pharmaceutics 19(8), 2776-2794, 2022 (DOI: 10.1021/acs.molpharmaceut.2c00148).
5)
Seyoung Kim, Daniel J. Fesenmeier, Sungwan Park, Sandra
E. Torregrosa-Allen, Bennett D. Elzey, You-Yeon Won, ʺPulmonary Pharmacokinetics of Polymer Lung
Surfactants Following Pharyngeal Administration in Miceʺ, Biomacromolecules
23(6), 2471-2484, 2022 (DOI: 10.1021/acs.biomac.2c00221).
6)
Daniel J. Fesenmeier, Sungwan Park, Seyoung Kim,
You-Yeon Won, ʺSurface Mechanical Behavior of Water-Spread
Poly(styrene)-Poly(ethylene glycol) (PS-PEG) Micelles at the Air-Water
Interface: Effect of Micelle Size and Polymer End/Linking Group Chemistryʺ,
Journal of Colloid and Interface Science
617, 764-777, 2022 (DOI: 10.1016/j.jcis.2022.03.008).
7)
Jin Yoo, Dhushyanth
Viswanath, You-Yeon Won, ʺStrategy
for Synthesis of Statistically Sequence-Controlled PEG-PLGA, and Effects of Sequence
Distribution on Interaction and Drug Release Propertiesʺ, ACS
Macro Letters 10, 1510-1516, 2021 (DOI: 10.1021/acsmacrolett.1c00637).
8)
Samruddhi Patil, Jin Yoo, You-Yeon Won, ʺInvestigation of the Mechanisms
and Kinetics of DBU-Catalyzed PLGA Copolymerization via a Full-Scale Population
Balance Analysisʺ, Industrial &
Engineering Chemistry Research 60(41), 14865-14700, 2021 (DOI: 10.1021/acs.iecr.1c03096).
9)
Anish P. Patel, Christopher R. Schorr, Dhushyanth Viswanath, Kaustabh
Sarkar, Natalie J. Streb, Vincenzo J. Pizzuti, Rahul Misra, Jaewon Lee, You-Yeon Won, ʺPilot-Scale Optimization of the Solvent Exchange
Production and Lyophilization Processing of PEG-PLA Block
Copolymer-Encapsulated CaWO4 Radioluminescent
Nanoparticles for Theranostic Applicationsʺ,
Industrial & Engineering Chemistry
Research 60(19), 7082-7096, 2021 (DOI: 10.1021/acs.iecr.0c05852).
10)
Y.-Y. Won, D. Ramkrishna, ʺAddition
to ʺRevised Formulation of Fickʹs, Fourierʹs, and Newtonʹs
Laws for Spatially Varying Linear Transport Coefficientsʺʺ, ACS Omega 5(51), 33484-33487, 2020 (DOI:
10.1021/acsomega.0c02856).
11)
J. Yoo, Y.-Y. Won, ʺPhenomenology
of the Initial Burst Release of Drugs from PLGA Microparticlesʺ, ACS Biomaterials Science & Engineering 6(11),
6053-6062, 2020 (DOI: 10.1021/acsbiomaterials.0c01228).
12)
D. W.
Kim, G. A. Medvedev, J. M. Caruthers, J. Y. Jo, Y.-Y. Won, J. Kim, ʺEnhancement of Mechano-Sensitivity for Spiropyran-Linked Poly(dimethylsiloxane)
via Solvent Swellingʺ, Macromolecules
53(18), 7954-7961, 2020 (DOI: 10.1021/acs.macromol.0c00985).
13)
V. J. Pizzuti, D. Viswanath, S. E. Torregrosa-Allen, M.
P. Currie, B. D. Elzey, Y.-Y. Won, ʺBilirubin-Coated Radio-Luminescent Particles for Radiation-Induced
Photodynamic Therapyʺ, ACS Applied
Bio Materials 3(8), 4858-4872, 2020 (DOI: 10.1021/acsabm.0c00354).
14)
J. Lee, J. Pan, J. Chun, Y.-Y. Won, ʺUnexpected
Conformational Behavior of Poly(poly(ethylene glycol) methacrylate)-Poly(propylene
carbonate)-Poly(poly(ethylene glycol) methacrylate) (PPEGMA-PPC-PPEGMA)
Amphiphilic Block Copolymers in Micellar Solution and at the Air-Water
Interfaceʺ, Journal of Colloid and
Interface Science 566, 304-315, 2020 (DOI: 10.1016/j.jcis.2020.01.080). Corrigendum: Journal
of Colloid and Interface Science 586, 596, 2021 (DOI: 10.1016/j.jcis.2020.10.126).
15)
V. J. Pizzuti, R. Misra, J. Lee, S. E. Torregrosa-Allen, M. P. Currie, S. R. Clark, A. P. Patel, C. R. Schorr,
Y. Jones-Hall, M. O. Childress, J. M. Plantenga, N.
J. Rancilio, B. D. Elzey, Y.-Y. Won, ʺFolic
Acid-Conjugated Radioluminescent Calcium Tungstate
Nanoparticles as Radio-Sensitizers
for Cancer Radiotherapyʺ, ACS
Biomaterials Science & Engineering 5(9), 4776-4789, 2019 (DOI: 10.1021/acsbiomaterials.9b00773).
16)
Y.-Y. Won, D. Ramkrishna, ʺRevised
Formulation of Fickʹs, Fourierʹs,
and Newtonʹs Laws for Spatially Varying Linear
Transport Coefficientsʺ, ACS Omega
4(6), 11215-11222, 2019 (DOI: 10.1021/acsomega.9b00736).
17)
R. Misra, K. Sarkar, J. Lee,
V. J. Pizzuti, D. S. Lee, M. P. Currie, S. E. Torregrosa-Allen, D. E. Long, G. A. Durm,
M. P. Langer, B. D. Elzey, Y.-Y. Won, ʺRadioluminescent Nanoparticles for Radiation-Controlled
Release of Drugsʺ, Journal of
Controlled Release 303, 237-252, 2019 (DOI: 10.1016/j.jconrel.2019.04.033).
18)
B. Chun, J. S. Park, H. W. Jung, Y.-Y. Won, ʺShear-Induced
Particle Migration and Segregation in Non-Brownian Bidisperse
Suspensions under Planar Poiseuille Flowʺ, Journal of Rheology 63(3), 437-453, 2019 (DOI: 10.1122/1.5065406).
19)
H. C. Kim, M. V. Suresh, V. V. Singh, D. Q. Arick, D.
A. Machado-Aranda, K. Raghavendran, Y.-Y.
Won, ʺPolymer Lung Surfactantsʺ, ACS
Applied Bio Materials 1(3),
581-592, 2018
(DOI: 10.1021/acsabm.8b00061).
20)
J. Lee, S. D.
Jo, H. Chung, W. Um, R. Chandrasekar, Y. H. Choi, V. M. Shalaev,
Y.-Y. Won, ʺLaser-Induced CO2 Generation from Gold
Nanorod-Containing Poly(propylene carbonate)-Based
Block Polymer Micelles for Ultrasound Contrast Enhancementʺ, ACS Applied Materials & Interfaces 10(31), 26084-26098, 2018 (DOI: 10.1021/acsami.8b09630).
21)
H. C. Kim, D. Q. Arick, Y.-Y. Won, ʺAir-Water
Interfacial Properties of Chloroform-Spread versus Water-Spread Poly((D,L-lactic acid-co-glycolic
acid)-block-ethylene glycol)
(PLGA-PEG) Polymersʺ, Langmuir 34(16),
4874-4887, 2018 (DOI: 10.1021/acs.langmuir.8b00566).
22)
H. C. Kim, Y.-Y. Won, ʺClinical, Technological, and Economic Issues
Associated with Developing New Lung Surfactant Therapeuticsʺ, Biotechnology Advances 36(4), 1185-1193,
2018 (DOI: 10.1016/j.biotechadv.2018.03.017).
23)
S. D. Jo, J. Lee, M. K. Joo,
V. Pizzuti, N. J. Sherck,
S. Choi, B. S. Lee, S. H. Yeom, S. Y. Kim, S. H. Kim,
I. C. Kwon, Y.-Y. Won, ʺPEG-PLA-Coated and Uncoated Radio-Luminescent CaWO4
Micro- and Nanoparticles for Concomitant Radiation and UV-A/Radio-Enhancement
Cancer Treatmentsʺ, ACS Biomaterials
Science & Engineering 4(4), 1445-1462, 2018 (DOI: 10.1021/acsbiomaterials.8b00119).
24)
S. R. Clark, K. Y. Lee, H. Lee, J. Khetan,
H. C. Kim, Y. H. Choi, K. W. Shin, Y.-Y. Won, ʺDetermining the Effects of
PEI Adsorption on the Permeability of 1,2-Dipalmitoylphosphatidylcholine/Bis(monoacylglycero)phosphate Membranes under Osmotic Stressʺ,
Acta Biomaterialia
65, 317-326, 2018 (DOI: 10.1016/j.actbio.2017.10.027).
25)
N. J. Sherck, Y.-Y. Won, ʺA
Simulation Study on the Feasibility of Radiotherapy Dose Enhancement with
Calcium Tungstate and Hafnium Oxide Nano- and Microparticlesʺ, Medical Physics 44(12), 6583-6588, 2017
(DOI: 10.1002/mp.12588). An earlier and longer version of this article
(titled ʺA Simulation Study on the Feasibility
of Radio Enhancement Therapy with Calcium Tungstate and Hafnium Oxide
Nanoparticlesʺ) has been published in arXiv
(http://arxiv.org/abs/1608.05302).
26)
S.-E.
Kim, B.-R. Lee, H. Lee, S. D. Jo, H. Kim, Y.-Y. Won, J. Lee, ʺNear-Infrared
Plasmonic Assemblies of Gold Nanoparticles with Multimodal Functions for
Targeted Cancer Theragnosisʺ, Scientific
Reports 7, 17327, 2017 (DOI:10.1038/s41598-017-17714-2).
27)
H. C. Kim, Y. H. Choi, W. Bu, M. Meron,
B. Lin, Y.-Y. Won, ʺIncreased Humidity Can Soften Glassy Langmuir Polymer
Films by Two Mechanisms: Plasticization of the Polymer Material, and
Suppression of the Evaporation Cooling Effectʺ, Physical Chemistry Chemical Physics 19, 10663-10675, 2017 (DOI:
10.1039/C7CP00785J).
28)
S.-E. Kim, S. D. Jo, K. C. Kwon, Y.-Y. Won, J. Lee, ʺGenetic
Assembly of Double-Layered Fluorescent Protein Nanoparticles for Cancer
Targeting and Imagingʺ, Advanced
Science 1600471, 2017 (DOI: ).
29)
J. Lee,
S. Choi, K. H. Kim, H. G. Heng, S. E. Torregrosa-Allen,
B. S. Ramsey, B. D. Elzey, Y.-Y. Won, ʺNon-Toxic
Formulations of Scintillation Nanocrystals for Use as X-Ray Computed Tomography
(CT) Contrast Agentsʺ, Bioconjugate
Chemistry 28(1), 171-182, 2017 (DOI: 10.1021/acs.bioconjchem.6b00451).
30)
N. J. Sherck, H. C. Kim,
Y.-Y. Won, ʺElucidating a Unified Mechanistic Scheme for the DBU-Catalyzed
Ring-Opening Polymerization of Lactide to Poly(lactic
acid), PLAʺ, Macromolecules
49(13), 4699-4713, 2016 (DOI: 10.1021/acs.macromol.6b00621).
31)
S. D. Jo,
S. H. Ku, Y.-Y. Won, S. H. Kim, I. C. Kwon, ʺTargeted Nanotheranostics for Future
Personalized Medicine: Recent Progress in Cancer Therapyʺ, Theranostics 6(9), 1362-1377,
2016 (DOI: 10.7150/thno.15335).
32)
J. Lee, N. J. Rancilio, J.
M. Poulson, Y.-Y. Won, ʺBlock Copolymer-Encapsulated CaWO4
Nanoparticles: Synthesis, Formulation, and Characterizationʺ, ACS Applied Materials & Interfaces 8(13), 8608-8619, 2016 (DOI:
10.1021/acsami.6b00727).
33)
H. C. Kim, H. Lee, J. Khetan,
Y.-Y. Won, ʺSurface Mechanical and Rheological Behaviors of Biocompatible Poly((D,L-lactic acid-ran-glycolic acid)-block-ethylene glycol) (PLGA-PEG) and
Poly((D,L-lactic acid-ran-glycolic
acid-ran-ε-caprolactone)-block-ethylene glycol) (PLGACL-PEG)
Block Copolymers at the Air-Water Interfaceʺ, Langmuir 31(51), 13821-13833, 2015 (DOI: 10.1021/acs.langmuir.5b03622).
34)
D. Q. Arick, Y. H. Choi, H. C. Kim, Y.-Y. Won, ʺEffects
of Nanoparticles on the Mechanical Functioning of the Lungʺ, Advances in Colloid and Interface Science
225, 218-228, 2015 (DOI: 10.1016/j.cis.2015.10.002).
35)
H. Lee, J. Lee, J. Park, T. Kwon, S. Hong, Y.-Y. Won, ʺCO2-Producing
Polymer Micellesʺ, Polymer
Degradation and Stability 120, 149-157, 2015 (DOI:
10.1016/j.polymdegradstab.2015.07.002).
36)
H. C. Kim, H. Lee, H. J. Jung, Y. H. Choi, M. Meron, B. Lin, J. Bang, Y.-Y. Won, ʺHumidity-Dependent
Compression-Induced Glass Transition of the Air-Water Interfacial Langmuir
Films of Poly(D,L-lactic acid-ran-glycolic acid) (PLGA)ʺ, Soft Matter 11, 5666-5677, 2015 (DOI:
10.1039/C4SM02535K).
37)
H. Kim, J. Lee, Y.-Y. Won, ʺA Simple Derivation
of the Critical Condition for the Ultrasonic Atomization of Polymer Solutionsʺ
Ultrasonics
61, 20-24, 2015 (DOI: 10.1016/j.ultras.2015.04.007).
38)
V. Tsouris, M. K. Joo, S. H. Kim, I. C. Kwon, Y.-Y. Won, ʺNano Carriers
That Enable Co-Delivery of Chemotherapy and RNAi Agents for Treatment of
Drug-Resistant Cancersʺ, Biotechnology
Advances 32(5), 1037-1050, 2014 (DOI:
39)
H. Lee, V. Tsouris, Y. Lim,
R. Mustafa, J. Choi, Y. H. Choi, H.-W. Park, M. Meron,
B. Lin, Y.-Y. Won, ʺMacroscopic Lateral Heterogeneity Observed in a
Laterally-Mobile Immiscible Mixed Polyelectrolyte/Neutral Polymer Brushʺ, Soft Matter 10, 3771-3782, 2014 (DOI: 10.1039/C4SM00022F).
40)
H. Lee, Y. Kim, P. G. Schweickert,
S. F. Konieczny, Y.-Y. Won, ʺA Photo-Degradable Gene Delivery System for
Enhanced Nuclear Gene Transcriptionʺ, Biomaterials
35(3), 1040-1049, 2014 (DOI:
41)
Y.-Y. Won, H. Lee, ʺʺpH Phoresisʺ:
A New Concept That Can Be Used for Improving Drug Delivery to Cancer Cellsʺ,
Journal of Controlled Release 170(3),
396-400, 2013 (DOI: 10.1016/j.jconrel.2013.06.016). See ʺNanoparticles, ʹpH phoresisʹ could improve cancer drug deliveryʺ
in Purdue News (July 8, 2013).
42)
D. J. Gary, J. Min, Y. Kim, K. Park, Y.-Y. Won, ʺThe
Effect of N/P Ratio on the In Vitro
and In Vivo Interaction Properties of
PEGylated Poly(2-(dimethylamino)ethyl methacrylate)-Based siRNA Complexesʺ, Macromolecular
Bioscience 13(8), 1059-1071, 2013 (DOI: 10.1002/mabi.201300046).
43)
H. W. Park, J. Choi, K. Ohn,
H. Lee, J. W. Kim, Y.-Y. Won, ʺStudy of the Air-Water Interfacial Properties
of Biodegradable Polyesters and Their Block Copolymers with Poly(ethylene
glycol)ʺ, Langmuir 28(31),
11555-11566, 2012 (DOI: 10.1021/la300810q).
44)
H. Lee, D. H. Kim, K. N. Witte, K. Ohn,
J. Choi, B. Akgun, S. Satija,
Y.-Y. Won, ʺWater is a Poor
Solvent for Densely Grafted Poly(ethylene oxide)
Chains: A Conclusion Drawn from a Self-Consistent Field Theory-Based Analysis
of Neutron Reflectivity and Surface Pressure-Area Isotherm Dataʺ, Journal of Physical Chemistry B 116(24),
7367-7378, 2012 (DOI: 10.1021/jp301817e).
45)
H. Lee, D. H. Kim, H.-W. Park, N. A. Mahynski, K. Kim, M. Meron, B.
Lin, Y.-Y. Won, ʺReduced Water Density in a Poly(ethylene
oxide) Brushʺ, Journal of Physical
Chemistry Letters 3, 1589-1595, 2012
(DOI: 10.1021/jz3002772).
46)
D. H. Kim, A. Wei, Y.-Y. Won, ʺPreparation of
Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micellesʺ,
ACS Applied Materials & Interfaces
4(4), 1872-1877, 2012 (DOI: 10.1021/am300198v).
47)
R. Nap, Y.-Y. Won, I. Szleifer,
ʺConfinement Induced Lateral Segregation of Polymer Coated Nanospheresʺ,
Soft Matter 8(5), 1688-1700, 2012
(DOI: 10.1039/c2sm06549e).
48)
D. H. Kim, Y.-Y. Won, ʺIn Situ-Polymerized Carbon
Nanotube/Polyimide Nanocomposites: Effect of Reaction Stoichiometry on the
Glass Transition Properties of the Nanocompositesʺ, Macromolecular Reaction Engineering 6(1), 45-56, 2012 (DOI:
10.1002/mren.201100027). This article has been highlighted on the front
cover of the journal.
49)
D. J. Gary, H. Lee, R. Sharma, J.-S. Lee, Y. Kim, Z.
Y. Cui, D. Jia, V. D. Bowman, P. R. Chipman, L. Wan, Y. Zou, G. Mao, K. Park,
B.-S. Herbert, S. F. Konieczny, Y.-Y. Won, ʺInfluence of Nano-Carrier
Architecture on In Vitro siRNA Delivery Performance and In Vivo
Biodistribution: Polyplexes vs. Micelleplexesʺ, ACS Nano 5(5), 3493-3505, 2011 (DOI:
10.1021/nn102540y).
50)
H. Lee, S. H. Son, R. Sharma, Y.-Y. Won, ʺA
Discussion of the pH-Dependent Protonation Behaviors of Poly(2-(dimethylamino)ethyl
methacrylate) (PDMAEMA) and Poly(ethylenimine-ran-2-ethyl-2-oxazoline) (P(EI-r-EOz))ʺ, Journal
of Physical Chemistry B 115(5), 844-860, 2011 (DOI: 10.1021/jp109151s).
51)
U. S. Kestur, H. Lee, D.
Santiago, C. Rinaldi, Y.-Y. Won, L. S. Taylor, ʺEffects of the Molecular
Weight and Concentration of Polymer Additives, and Temperature on the Melt
Crystallization Kinetics of a Small Drug Moleculeʺ, Crystal Growth & Design 10(8),
3585-3595, 2010 (DOI: 10.1021/cg1004853).
52)
J. Hur, N. A. Mahynski, Y.-Y. Won, ʺCrystallization of Bidisperse Repulsive Colloids in Two-Dimensional Space: A
Study of Model Systems Constructed at the Air-Water Interfaceʺ, Langmuir 26(14),
11737-11749, 2010 (DOI: 10.1021/la101313r).
53)
K. N. Witte, S. Kewalramani,
I. Kuzmenko, W. Sun, M. Fukuto,
Y.-Y. Won, ʺFormation and Collapse of Single-Monomer-Thick Monolayers of Poly(n-Butyl
Acrylate) at the Air-Water Interfaceʺ, Macromolecules
43(6), 2990-3003, 2010 (DOI: 10.1021/ma901842q).
54)
J. Hur, K. N. Witte, W. Sun,
Y.-Y. Won, ʺOn the Origins of the Salt-Concentration-Dependent Instability
and Lateral Nanoscale Heterogeneities of Weak Polyelectrolyte Brushes: Gradient
Brush Experiment, and Flory-Type Theoretical Analysisʺ, Langmuir 26(3), 2021-2034, 2010 (DOI:
10.1021/la902549b).
55)
Y.-Y. Won, R. Sharma, S. F. Konieczny, ʺMissing
Pieces in Understanding the Intracellular Trafficking of Polycation/DNA
Complexesʺ, Journal of Controlled
Release 139(2), 88-93, 2009 (DOI: 10.1016/j.jconrel.2009.06.031).
Erratum: Journal of Controlled Release 152(2),
326, 2009 (DOI: 10.1016/j.jconrel.2011.04.003).
56)
K. N. Witte, S. Kim, Y.-Y. Won, ʺSelf-Consistent
Field Theory Study of the Effect of Grafting Density on the Height of a Weak
Polyelectrolyte Brushʺ, Journal of
Physical Chemistry B 113(32), 11076-11084, 2009 (DOI: 10.1021/jp809814j).
57)
K. N. Witte, J. Hur, W. Sun,
S. Kim, Y.-Y. Won, ʺEvidence of Lateral Nanoscale Heterogeneities in Weak
Polyelectrolyte Brushesʺ, Macromolecules
41(23), 8960-8963, 2008 (DOI: 10.1021/ma801412u).
58)
R. Sharma, J.-S. Lee, R. C. Bettencourt, C. Xiao, S.
F. Konieczny, Y.-Y. Won, ʺEffects
of the Incorporation of a Hydrophobic Middle Block into a PEG-Polycation Diblock Copolymer on the Physicochemical and Cell
Interaction Properties of the Polymer-DNA Complexesʺ, Biomacromolecules 9(11), 3294-3307, 2008
(DOI: 10.1021/bm800876v).
59)
J. Hur, Y.-Y. Won, ʺFabrication of High-Quality Non-Close-Packed
2D Colloid Crystals by Template-Guided Langmuir-Blodgett (LB) Particle
Depositionʺ, Soft Matter
4(6), 1261-1269, 2008 (DOI: 10.1039/b716218a). See ʺSelf-assembling Method Could Lead to
Inexpensive Diamond-like Crystals for Technologyʺ in
ScienceDaily (April 22, 2008). This article was one of the ten most downloaded
Soft Matter articles for April 2010 (http://www.rsc.org/publishing/journals/sm/top10.asp)
60)
J. Hur, Y.-Y. Won, ʺTwo-Dimensional
Colloid Crystals Templated by Polyelectrolyte Multilayer Patternsʺ, Langmuir 24(10), 5382-5392, 2008 (DOI: 10.1021/la704050t).
61)
K. N. Witte, Y.-Y. Won, ʺEffect
of Interfacial Curvature on Mixed Polyelectrolyte and Neutral Polymer Brushes:
An SCF Numerical Analysisʺ, Macromolecules
41(7), 2735-2738, 2008 (DOI: 10.1021/ma071682e).
62)
Y. Zhao, M. T.
Carvajal, Y.-Y. Won, M. T. Harris, ʺPreparation of Calcium Alginate
Microgel Beads by an Electrodispersion Reactor Using
an Internal Source of Calcium Carbonate Nanoparticlesʺ, Langmuir 23(25), 12489-12496, 2007 (DOI: 10.1021/la701795y).
63)
D. Zhu, M. A. Haidekker,
J.-S. Lee, Y.-Y. Won, J. C.-M. Lee, ʺApplication of Molecular Rotors
to the Determination of the Molecular Weight-Dependence of Viscosity in Polymer
Meltsʺ, Macromolecules 40(21),
7730-7732, 2007 (DOI: 10.1021/ma0702288).
64)
D. J. Gary, N. Puri, Y.-Y.
Won, ʺPolymer-Based siRNA Delivery: Perspectives on the Fundamental and
Phenomenological Distinctions from Polymer-Based DNA Deliveryʺ, Journal of Controlled Release 121(1-2),
64-73, 2007 (DOI: 10.1016/j.jconrel.2007.05.021).
65)
K.
N. Witte, Y.-Y. Won, ʺSelf-Consistent
Field (SCF) Analysis of Mixed Polyelectrolyte and Neutral Polymer Brushesʺ,
Macromolecules 39(22),
7757-7768, 2006 (DOI: 10.1021/ma0608370).
66)
R. Sharma, A. Goyal, J. M. Caruthers, Y.-Y. Won, ʺInhibitive Chain Transfer to
Ligand in the ATRP of n-Butyl Acrylateʺ, Macromolecules
39(14), 4680-4689, 2006 (DOI: 10.1021/ma060374y).
67)
Y.-Y. Won, S. P. Meeker, V. Trappe, D. A. Weitz, N. Z.
Diggs, J. I. Emert, ʺEffect of Temperature on
Carbon Black Agglomeration in Hydrocarbon Liquid with Adsorbed Dispersantʺ,
Langmuir 21(4), 924-932, 2005
(DOI: 10.1021/la047906t).
68)
P. E. Trapa, Y.-Y. Won, S.
C. Mui, E. A. Olivetti, B. Huang, D. R. Sadoway,
A. M. Mayes, S. Dallek, ʺRubbery Graft Copolymer
Electrolytes for Solid-State, Thin-Film Lithium Batteriesʺ, Journal of the Electrochemical Society
152(1), A1-A5, 2005 (DOI: 10.1149/1.1824032).
69)
Y.-Y. Won, ʺImaging Nanostructured Fluids Using
Cryo-TEMʺ, Korean Journal of Chemical Engineering 21(1), 296-302,
2004 (DOI: 10.1007/BF02705412). This article has been referenced in an
STTR call from the US Army, titled ʺNanoscale In-Solution TEM Sample Stage
with Manipulation Capability (A08-T029)ʺ (January
22, 2008).
70)
Y.-Y. Won, H. T. Davis, F. S. Bates, ʺMolecular
Exchange in PEO-PB Micelles in Waterʺ, Macromolecules 36(3),
953-955, 2003 (DOI: 10.1021/ma021439+).
71)
M. M. Santore, D. E. Discher, Y.-Y. Won, F. S. Bates, D. A. Hammer, ʺEffect
of Surfactant on Unilamellar Polymeric Vesicles:
Altered Membrane Properties and Stability in the Limit of Weak Surfactant
Partitioningʺ, Langmuir 18(20), 7299-7308, 2002 (DOI:
10.1021/la0201319).
72)
J. F. Hester, P. Banergee,
Y.-Y. Won, A. Akthakul, M. H. Acar,
A. M. Mayes, ʺATRP of Amphiphilic Graft Copolymers Based on PVDF and Their
Use as Membrane Additivesʺ, Macromolecules 35(20), 7652-7661, 2002
(DOI: 10.1021/ma0122270).
73)
P. E. Trapa, B. Huang, Y.-Y.
Won, D. R. Sadoway, A. M. Mayes, ʺBlock
Copolymer Electrolytes Synthesized by Atom Transfer Radical Polymerization for
Solid-State, Thin-Film Lithium Batteriesʺ, Electrochemical and Solid-State
Letters 5(5), A85-A88, 2002 (DOI: 10.1149/1.1461996).
74)
Y.-Y. Won, A. K. Brannan, H. T. Davis, F. S. Bates, ʺCryogenic
Transmission Electron Microscopy (Cryo-TEM) of Micelles and Vesicles Formed in
Water by Poly(ethylene oxide)-based Block Copolymersʺ,
Journal of Physical Chemistry B 106(13), 3354-3364, 2002 (DOI:
10.1021/jp013639d).
75)
B. M. Discher, H. Bermudez,
D. A. Hammer, D. E. Discher, Y.-Y. Won, F. S. Bates, ʺCrosslinked
Polymersome Membranes: Vesicles with Broadly
Adjustable Stabilityʺ, Journal of Physical Chemistry B 106(11),
2848-2854, 2002 (DOI: 10.1021/jp011958z).
76)
Y.-Y. Won, K. Paso, H. T. Davis, F. S. Bates, ʺComparison
of Original and Cross-linked Wormlike Micelles of Poly(ethylene
oxide-b-butadiene) in Water: Rheological Properties and Effects of
Poly(ethylene oxide) Additionʺ, Journal of Physical Chemistry B
105(35), 8302-8311, 2001 (DOI: 10.1021/jp004078d).
77)
J. C.-M. Lee, H. Bermudez, B. M. Discher,
M. Sheehan, Y.-Y. Won, F. S. Bates, D. E. Discher, ʺPreparation,
Stability, and In Vitro Performance
of Vesicles Made from Diblock Copolymersʺ, Biotechnology
and Bioengineering 73(2), 135-145, 2001 (DOI: 10.1002/bit.1045).
78)
B. Jeong, M. R. Kibbey, J. C. Birnbaum, Y.-Y. Won, A. Gutowska,
ʺThermogelling Biodegradable Polymers with
Hydrophilic Backbones: PEG-g-PLGAʺ, Macromolecules 33(22),
8317-8322, 2000 (DOI: 10.1021/ma000638v).
79)
Y.-Y. Won, H. T. Davis, F. S. Bates, M. Agamalian, G. D. Wignall, ʺSegment
Distribution of the Micellar Brushes of Poly(ethylene
oxide) via Small-Angle Neutron Scatteringʺ, Journal of Physical
Chemistry B 104(30), 7134-7143, 2000 (DOI: 10.1021/jp000457v).
Addition/Correction: Journal of Physical Chemistry B 104(38), 9054-9054,
2000 (DOI: 10.1021/jp002934f).
80)
Y. Zheng, Y.-Y. Won, F. S. Bates, H. T. Davis, L. E.
Scriven, Y. Talmon, ʺDirectly Resolved
Core-Corona Structure of Block Copolymer Micelles by Cryo-Transmission Electron
Microscopyʺ, Journal of Physical Chemistry B 103(47), 10331-10334,
1999 (DOI: 10.1021/jp9923264).
81)
B. M. Discher, Y.-Y. Won, J.
C.-M. Lee, J. Eggs, F. S. Bates, D. E. Discher, D. A.
Hammer, ʺPolymersomes: Vesicles Made from Diblock Copolymersʺ, Science 284 (5417),
1143-1146, 1999 (DOI: 10.1126/science.284.5417.1143).
82)
Y.-Y. Won, H. T. Davis, F. S. Bates, ʺGiant
Wormlike Rubber Micellesʺ, Science 283 (5404), 960-963, 1999 (DOI:
10.1126/science.283.5404.960).
83)
Y.-Y.
Won, F. S. Bates, ʺNonionic Block Copolymer Wormlike Micellesʺ, in Giant Micelles: Properties and Applications
(Editors: R. Zana, E. W. Kaler), CRC Press/Taylor
& Francis, Boca Raton, FL, 2007.
PUBLISHED PATENTS
84)
(a) ʺRadioluminescent
Nanoparticles for Radiation-Triggered Controlled Release Drugsʺ Y.-Y. Won,
R. Misra, J. Lee, pending U.S. Provisional Patent, Application No. 62/556,289, PRF Reference No. 68028-01, filed on September 8, 2017. (b) ʺRadioluminescent Nanoparticles for Radiation-Triggered
Controlled Release Drugsʺ Y.-Y. Won, R. Misra,
J. Lee, K. Sarkar, V. J. Pizzuti, pending PCT/U.S. Patent, Application No. 18/49823,
PRF Reference No. 68028-02, filed on
September 7, 2018.
85)
(a) ʺPolymer Lung Surfactantsʺ Y.-Y. Won, H.
C. Kim, pending U.S. Provisional Patent,
Application No. 62/374,325, PRF
Reference No. 67605-01, filed on
August 12, 2016. (b) ʺPolymer Lung Surfactantsʺ Y.-Y. Won, H. C.
Kim, pending PCT/U.S. Patent, Application No.
17/46426, PRF
Reference No. 67605-02, filed on
August 11, 2017. (c) ʺPolymer Lung Surfactantsʺ Y.-Y. Won, H. C.
Kim, pending U.S. Continuation-in-Part Patent,
Application No. 15881723, PRF Reference No. 67605-03, filed on January 26, 2018.
86)
(a) ʺRadio-Luminescent Particles for Enhancement
of Radiation Cancer Therapyʺ, Y.-Y. Won, M. K. Joo,
B. S. Lee, S. Y. Kim, pending
U.S. Provisional Patent, Application
No. 62/101,275, PRF Reference No. 78695.P1.US, filed on January 8, 2015. (b) ʺRadio-Luminescent
Particles for Enhancement of Radiation Cancer Therapyʺ, Y.-Y. Won, J. Lee,
S. D. Jo, M. K. Joo, B. S. Lee, S. Y. Kim, S. H. Kim,
pending PCT/U.S.
Patent, Application No. 16/12616, PRF Reference No. 67028-03, filed on
January 8, 2016. (c) ʺNon-Toxic Formulations of Radio-Luminescent
Nanoparticles for Use as Cancer Radio-Sensitizing Agentsʺ Y.-Y. Won, J.
Lee, pending PCT/U.S. Patent, Application No.
16/12684, PRF Reference No. 67028-02, filed on January 8, 2016. (d) ʺNon-Toxic
Formulations of Radio-Luminescent Nanoparticles for Use as Cancer
Radio-Sensitizing Agentsʺ Y.-Y. Won, J. Lee, nationalized in the U.S. on July 8, 2017 (PRF Reference
No. 67028-04). (e) ʺNon-Toxic Formulations of Radio-Luminescent
Nanoparticles for Use as Cancer Radio-Sensitizing Agentsʺ Y.-Y. Won, J.
Lee, nationalized in
the E.U. on August 8, 2017 (PRF Reference No. 67028-05).
87)
(a) ʺPoly(alkylene
carbonate)-Based Amphiphilic Block Copolymers and Methods of Use Thereofʺ,
Y.-Y. Won, H. Lee, J. Lee, J. Park, S. Hong, pending U.S.
Provisional Patent, Application No. 62/078,738, PRF
Reference No. 78595.P1.US, filed on November 12, 2014. (b) ʺPoly(alkylene
carbonate)-Based Amphiphilic Block Copolymers and Methods of Use Thereofʺ,
Y.-Y. Won, H. Lee, J. Lee, J. Park, S. Hong, pending PCT/U.S.
Patent, Application No. 15/60430, PRF Reference No. 66901-02, filed on
November 12, 2015. (c) ʺPoly(alkylene carbonate)-Based Amphiphilic Block Copolymers
and Methods of Use Thereofʺ, Y.-Y. Won, H. Lee, J. Lee, J. Park, S. Hong,
nationalized in the U.S. on May 12, 2017 (PRF Reference
No. 66901-03).
88)
(a) ʺPreparation of
Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micellesʺ, Y.-Y. Won, D. H. Kim, pending U.S. Provisional Patent, Application No.
61/619,548, PRF Reference No. 66166.P1.US, filed on April 3, 2012. (b) ʺBlock
Copolymer (BCP) Encapsulated Nanoparticles and Methods of Use Thereofʺ,
Y.-Y. Won, D. H. Kim, R. P. Andres, pending U.S. Patent, Application No. 13/837,705, PRF
Reference No. 66166-02, filed on March 15, 2013, granted on October 10, 2017.
89)
ʺCross-linked Polymersomes
and Related Encapsulating Membranesʺ, D. E. Discher,
B. M. Discher, Y.-Y. Won, J. C.-M. Lee, F. S. Bates,
D. A. Hammer, U.S. Patent No.
7,867,512, filed on February 20, 2007, granted on January 11, 2011.
90)
ʺPolymersomes and
Related Encapsulating Membranesʺ, D. E. Discher,
B. M. Discher, Y.-Y. Won, J. C.-M. Lee, F. S. Bates,
D. A. Hammer, U.S. Patent No.
7,217,427 B2, filed on July 1, 2004, granted on May 15, 2007.
91)
ʺPolymersomes and
Related Encapsulating Membranesʺ, D. E. Discher,
B. M. Discher, Y.-Y. Won, J. C.-M. Lee, F. S. Bates,
D. A. Hammer, U.S. Patent No. 6,835,394, filed
December 14, 1999, granted on December 28, 2004.