Ramkrishna Research Group
Lina is applying mathematics and information theory to systems biology and bioengineering. She works on a collaborative project with bioinformaticians and biochemists in Bioengineering at University of California, San Diego through the Center for Science of Information (CSOI).
Aside from her research interests, Lina is passionate about science communication and outreach initiatives. Much of her previous undergraduate and graduate work at Vanderbilt and Cornell were and continue to be centered around involvement in developing and enhancing K-12 STEM outreach programs. This is an initiative in which she is working to include computer science based lessons and activities.
Vu T Tran joined our research group in Fall 2012 as graduate research assistant. He is working on Modeling of Antibiotic/Drug Resistance in bacteria using population balance and stochastic process analysis
Parul Verma joined our research group in Fall 2014 as graduate research assistant. She is working on personalizing dosage of vincristine, administered to pediatric Acute Lymphoblastic Leukemia patients.
Akancha Pandey joined our research group in Fall 2014 as graduate research assistant. She is working on the model based optimal dosing strategy for sickle cell disease.
Alan is a second year undergraduate, doing a major in Mathematics/Computer Science. In his research with Professor Ramkrishna, he works with understanding DNA methylation, a process in which methyl groups are added to DNA primarily at CpG sites in mammals. They are currently using a diffusion model in order to understand the movement of DNA Methyltransferase (DNMT) along strands of DNA. They suppose that they are given the location of CpG sites in a strand of DNA and they are attempting to model the concentration of the DNA assuming that it’s in a steady state equilibrium. By understanding this mechanism, they hope to affect other research regarding diseases that are affected by methylation, such as cancer or Rett’s syndrome.