Ramkrishna Research Group
Lina is applying mathematics and information theory to systems biology and bioengineering. She works on a collaborative project with bioinformaticians and biochemists in Bioengineering at University of California, San Diego through the Center for Science of Information (CSOI).
Aside from her research interests, Lina is passionate about science communication and outreach initiatives. Much of her previous undergraduate and graduate work at Vanderbilt and Cornell were and continue to be centered around involvement in developing and enhancing K-12 STEM outreach programs. This is an initiative in which she is working to include computer science based lessons and activities.
Pelin joined our research group in Fall 2017 as a graduate research assistant. She is working on polymorph prediction by using molecular dynamics simulations to calculate polymorph specific nucleation rates. Following the work of Conor Parks based on Critical Nucleation theory (CNT) on molecular simulations data, Pelin is investigating the extension of nucleation scenarios more detailed than CNT to predict nucleation rates and other polymorph-specific properties.
Parul Verma joined our research group in Fall 2014 as graduate research assistant. She is working on chemotherapy induced peripheral neuropathy, which is a prevalent side effect arising due to many chemotherapy drugs. She is working on predicting which patient is susceptible to peripheral neuropathy, using patient data collected by clinicians at Riley hospital, Indianapolis. She uses machine learning algorithms to analyze patient data. In another project, she is developing a mathematical model to investigate the mechanism of peripheral neuropathy induction in a neuron.
Akancha Pandey joined our research group in Fall 2014 as graduate research assistant. She is working on the model based optimal dosing strategy for sickle cell disease.
Alan is a second year undergraduate, doing a major in Mathematics/Computer Science. In his research with Professor Ramkrishna, he works with understanding DNA methylation, a process in which methyl groups are added to DNA primarily at CpG sites in mammals. They are currently using a diffusion model in order to understand the movement of DNA Methyltransferase (DNMT) along strands of DNA. They suppose that they are given the location of CpG sites in a strand of DNA and they are attempting to model the concentration of the DNA assuming that it’s in a steady state equilibrium. By understanding this mechanism, they hope to affect other research regarding diseases that are affected by methylation, such as cancer or Rett’s syndrome.