Barcelona go into the Champions League quarter-final trailing 3-0 from the first leg.
Goals from Paulo Dybala (2) and Giorgio Chiellini mean the Catalan giants face an uphill battle to make the last four.
Should they progress, it would come just over a month after they historically overcame a 4-0 first leg battering from Paris Saint-Germain to go through.
And Spanish outlet Diario Gol claims Barcelona and star asset Lionel Messi are using famous wins over Real as a way to boost their chances of pulling off another unlikely win.