Barcelona are five points clear at the top of La Liga already after winning all of their opening seven matches this season.
While Atletico Madrid also go into the game unbeaten having won four and drawn three so far, putting them five points behind in fourth place.
And Niguez, who has played every minute of La Liga football this term, is confident his side can derail Barca’s impressive start to the campaign.
But the 22-year-old midfielder admits Atletico could struggle if Barcelona forward Lionel Messi brings his A game to the Wanda Metropolitano.