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Seminars in Hearing Research (9/9/21) - Jonatan Marcher-Rorsted

Seminars in Hearing Research (9/9/21) - Jonatan Marcher-Rorsted

Author: M. Heinz
Event Date: September 9, 2021
Hosted By: Hari Bharadwaj
Time: 1030-1120
Location: LYLE 1150
Contact Name: Bharadwaj, Hari M
Contact Email:
Open To: All
Priority: No
School or Program: Biomedical Engineering
College Calendar: Show
Jonatan Märcher-Rørsted (PhD candidate, Technical University of Denmark (DTU)) will present "Age-related reduction in frequency-following responses as a potential marker of cochlear neural degeneration" at our next Seminars in Hearing Research at Purdue (SHRP) on September 9th at 1030-1120 in LYLE 1150.

Seminars in Hearing Research at Purdue (SHRP)


Date: Thursday, September 9, 2021


Time: 10:30 – 11:20 am


Location: LYLE 1150


Title: Age-related reduction in frequency-following responses as a potential marker of cochlear neural degeneration


Speaker: Jonatan Märcher-Rørsted, PhD candidate, Technical University of Denmark (DTU)


Abstract: Previous studies have reported an age-related reduction in frequency-following responses (FFRs) in listeners with clinically normal audiometric thresholds. This has been argued to reflect an age-dependent decline in neural synchrony in the central auditory system. However, age-dependent degeneration of auditory nerve (AN) fibers may have little effect on audiometric sensitivity and may yet affect the suprathreshold coding of temporal information. This peripheral loss of temporal information may not be recovered centrally and may thus also contribute to reduced phase-locking accuracy in the auditory midbrain. Here, we investigated whether age-related reductions in the FFR could, at least in part, reflect age-dependent peripheral neural degeneration.


We combined human electrophysiology and auditory nerve (AN) modelling to investigate whether age-related changes in the FFR would be consistent with peripheral neural degeneration. A reduction in the FFR response in the older listeners was found across stimulation frequencies for both sweep and static pure-tone stimulation. Older listeners also showed significantly shallower MEMR growth level functions compared to the younger listeners, which could indicate a loss of low spontaneous rate fibers in the AN. Despite having clinically normal audiometric thresholds, the older listeners had significantly reduced sensitivity at frequencies above 8 kHz compared to the young group. The computational simulations suggested that such experimental results can be accounted for by neural degeneration already at the stage of the AN whereas a loss of sensitivity due to OHC dysfunction at higher frequencies could not explain the observed reduced FFR in the older listeners. These results are consistent with a peripheral source of the FFR reductions observed in older normal-hearing listeners, and indicate that FFRs at lower carrier frequencies may potentially be a sensitive marker of peripheral neural degeneration.



Zoom Info:


Meeting ID: 931 0815 8900

Passcode: 11501150





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